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人脑血管周细胞
英文名:Human Brain Vascular Pericytes
货号:1200
价格:¥12258.00
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人脑血管周细胞描述:


        周细胞是具伸缩性的类似平滑肌细胞的一类细胞,它们覆盖在微脉管的基底面。周细胞是小静脉的主要成分,并普遍存在于毛细血管中。在不同的组织和器官中,周细胞的数量和功能呈现很大的差异。周细胞的三种主要功能是(1)参与中枢神经系统微血管收缩性,(2)内皮细胞活性及(3)巨噬细胞活性的调节。也有证据表明周细胞与血脑屏障的物质转运及血管渗透性的调节有关。病理学研究显示,周细胞与高血压、糖尿病视网膜病变、阿尔海默氏病、多发性硬化和中枢神经系统肿瘤的形成有关。

    
        人脑血管周细胞 (HBVP)提取于人脑组织,原代冻存。每管含有细胞数 >5×105 cells/ml,此细胞通过对alpha-SMA抗体荧光免疫方法验证,经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。细胞可以达到15倍增。
 
推荐培养基:周细胞培养基PM, Cat. No. 1201)

产品使用说明
本产品仅用于科研,禁止用于人或动物体外诊断或临床应用。
货号 1200
产地 美国
缩写 HBVP
规格 5 x 10^5 cells/vial
用途 科研
运输 干冰
保存 液氮

1.) Zhou, Y., Zhang, H., Zheng, B., Ye, L., Zhu, S., Johnson, N.R., Wang, Z., Wei, X., Chen, D., Cao, G., Fu, X., Li, X., Xu, H.Z. & Xiao, J. (2016) Retinoic Acid Induced-Autophagic Flux Inhibits ER-Stress Dependent Apoptosis and Prevents Disruption of Blood-Spinal Cord Barrier after Spinal Cord Injury Int J Biol Sci. 12

2.) Navarro, R., Delgado-Wicke, P., Nunez-Prado, N., Compte, M., Blanco-Toribio, A., Nunez, G., Alvarez-Vallina, L. & Sanz, L. (2016) Role of nucleotide-binding oligomerization domain 1 (NOD1) in pericyte-mediated vascular inflammation J Cell Mol Med. 20

3.) Gurnik, S., Devraj, K., Macas, J., Yamaji, M., Starke, J., Scholz, A., Sommer, K., Di Tacchio, M., Vutukuri, R., Beck, H., Mittelbronn, M., Foerch, C., Pfeilschifter, W., Liebner, S., Peters, K.G., Plate, K.H. & Reiss, Y. (2016) Angiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling Acta Neuropathol. 131

4.) Yuan, K., Orcholski, M.E., Panaroni, C., Shuffle, E.M., Huang, N.F., Jiang, X., Tian, W., Vladar, E.K., Wang, L., Nicolls, M.R., Wu, J.Y. & de Jesus Perez, V.A. (2015) Activation of the Wnt/Planar Cell Polarity Pathway Is Required for Pericyte Recruitment during Pulmonary Angiogenesis Am J Pathol. 185

5.) Yang, W.J., Hu, J., Uemura, A., Tetzlaff, F., Augustin, H.G. & Fischer, A. (2015) Semaphorin-3C signals through Neuropilin-1 and PlexinD1 receptors to inhibit pathological angiogenesis EMBO Mol Med. 7

6.) Vanlandewijck, M., Lebouvier, T., Andaloussi Mae, M., Nahar, K., Hornemann, S., Kenkel, D., Cunha, S.I., Lennartsson, J., Boss, A., Heldin, C.H., Keller, A. & Betsholtz, C. (2015) Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification PLoS One. 10

7.) Schweller, R.M. & West, J.L. (2015) Encoding Hydrogel Mechanics via Network Cross-Linking Structure ACS Biomater Sci Eng. 1

8.) Li, J., Zhou, J., Zhang, D., Song, Y., She, J. & Bai, C. (2015) Bone marrow-derived mesenchymal stem cells enhance autophagy via PI3K/AKT signalling to reduce the severity of ischaemia/reperfusion-induced lung injury J Cell Mol Med. 19

9.) Bai, Y., Zhu, X., Chao, J., Zhang, Y., Qian, C., Li, P., Liu, D., Han, B., Zhao, L., Zhang, J., Buch, S., Teng, G., Hu, G. & Yao, H. (2015) Pericytes Contribute to the Disruption of the Cerebral Endothelial Barrier via Increasing VEGF Expression: Implications for Stroke PLoS One. 10

Click on Questions to view answers:

Posted by Daniel, Thursday, April 21, 2016 on product Human Brain Vascular Pericytes

Question:

Do you have an STR profile available for Human Brain Vascular Pericytes #1200?

Answers:

  • Posted by Manoj Sharma on Thursday, April 21, 2016

    Hi Daniel,

    We apologize for the inconvenience, but the STR profile for Catalog #1200 is not currently available. Please email your request to TechSupport@sciencellonline.com and we will respond as soon as possible.”

     Best,

    Sciencell Team

Posted by duan, Wednesday, April 20, 2016 on product Human Brain Vascular Pericytes

Question:

Are they GFAP positive?

Answers:

  • Posted by Manoj Sharma on Wednesday, April 20, 2016

    Hi duan,

    Human Brain Vascular Pericytes are NOT GFAP positive.

    Thank you

Posted by Lynn, Tuesday, March 29, 2016 on product Human Brain Vascular Pericytes

Question:

How are these cells isolated? Are they PDGFRb+? Do you know if they express other pericyte markers like NG2?

Answers:

  • Posted by Karishma Shah on Tuesday, March 29, 2016

    Dear customer,

    Isolation method is proprietary. #1200 cells express both PDGF beta receptor and NG2. 

Posted by Kuo-Fen Lee, Thursday, January 7, 2016 on product Human Brain Vascular Pericytes

Question:

Do you know the ApoE genotype information of these human pericytes? ApoE2, ApoE3 or ApoE4. Can request a specific one?

Answers:

  • Posted by Manoj Sharma on Thursday, January 7, 2016

    Hi,

    We do not test these. thanks for your interest, please email at techsupport@sciencellonline,.com for special services.

    SCIENCELL TEAM

Posted by Susan Lantz-McPeak, Thursday, January 7, 2016 on product Human Brain Vascular Pericytes

Question:

The spec sheet says you can passage these cells 15 times, but I don't see it listed anywhere that they are immortalized. Please clarify.

Answers:

  • Posted by Manoj Sharma on Thursday, January 7, 2016

    Hi Susan,

    The cells can proliferate for 15 population doublings, not 15 passages. Cells may reach 15 population doublings within 4-5 passages. thanks for your interest

    SCIENCELL

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