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人软脑膜周细胞
英文名:Human Leptomeningeal Pericytes
货号:1410
价格:¥12078.00
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人软脑膜周细胞描述:


       Central nervous system pericytes are perivascular cells that are closely associated with the endothelium of capillaries and other small vessels [1].  Pericytes, located near endothelial cells, communicate with other cells by extending long cytoplasmic processes which wrap around the capillaries [1, 2]. Pericytes participate in a variety of processes including angiogenesis, endothelial cell survival, regulation of capillary blood flow, and establishment and maintenance of the blood-brain barrier [3, 4]. Pericyte dysregulation has been linked to several pathological conditions such as hypertension, diabetic retinopathy, atherosclerosis, multiple sclerosis, Alzheimer’s disease, and tumor angiogenesis [2, 4].  The unique and diverse functions of pericytes make them novel candidates for cell therapy in regenerative medicine. Leptomeningeal pericytes (LP) are derived from the leptomeningeal layer surrounding the brain. Cultured human leptomeningeal pericytes (HLP) are a useful in vitro model for studying a wide variety of central nervous system diseases. 


        HLP from ScienCell Research Laboratories are isolated from human brain. HLP are cryopreserved at passage one after purification and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HLP are characterized by immunofluorescence with antibody specific to a-smooth muscle actin and platelet derived growth factor-b (PDGF-b). HLP are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HLP are guaranteed to further expand for 15 population doublings under the conditions provided by ScienCell Research Laboratories. 


 配套培养基:(PM, Cat. #1201


产品使用说明:仅供科研研究使用

货号 1410
产地 美国
缩写 HLP
规格 5 x 10^5 cells/vial
用途 科研
运输 干冰
保存 液氮

[1] Dore-Duffy P, Cleary K. (2011) "Morphology and properties of pericytes." Methods Mol Biol. 686:49-68.


[2] Allt G, Lawrenson JG. (2001) "Pericytes: cell biology and pathology." Cells Tissues Organs. 169: 1-11.

[3] Daneman R, Zhou L, Kebede A, Barres B. (2010) "Pericytes are required for blood-brain barrier integrity during embryogenesis" Nature. 468:562-566.

[4] Kutcher M, Herman I. (2009) "The pericyte: cellular regulator of microvascular blood flow." Microvasc Res. 77: 235-246.

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