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人肾系膜细胞
英文名:Human Renal Mesangial Cells
货号:4200
价格:¥11759.00
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人肾系膜细胞说明:

       

       人肾系膜细胞属于血管周细胞,位于肾小球毛细血管袢之间。系膜细胞有多种生理功能包括和分泌系膜基质,胞吞和加工血浆大分子,通过系膜细胞收缩和分泌血管活性激素控制肾小球血流动力学。肾系膜细胞增生和基质的过多产生是多种肾小球肾炎的主要病理表现,如IgA肾病,狼疮性肾炎,糖尿病肾病以及在肾小球硬化过程中细胞外基质增加。在培养中细胞增殖和基质合成/降解是通过细胞因子和生长因子调控的,因此细胞培养是研究系膜扩张、瘢痕形成和肾小球硬化的理想方法。   


        人肾系膜细胞(HRMC)提取于人肾脏组织,原代冻存。每管含有细胞数>5×105cells/ml,此细胞通过Fibronectin, Thy-1和smooth muscle actin免疫荧光染色验证,经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。细胞可以达到15倍增。


推荐培养基:肾系膜细胞培养基(MsCM, Cat. No. 4201)


产品使用说明:本产品仅用于科研


货号 4200
产地 美国
缩写 HRMC
规格 5 x 10^5 cells/vial
用途 科研
运输 干冰
保存 液氮

1.) Jia, Y., Guan, M., Zheng, Z., Zhang, Q., Tang, C., Xu, W., Xiao, Z., Wang, L. & Xue, Y. (2016) miRNAs in Urine Extracellular Vesicles as Predictors of Early-Stage Diabetic Nephropathy Journal of Diabetes Research. 2016

2.) Dai, Q., Liu, J., Du, Y., Hao, X., Ying, J., Tan, Y., He, L., Wang, W. & Chen, N. (2016) Histone deacetylase inhibitors attenuate P-aIgA1-induced cell proliferation and extracellular matrix synthesis in human renal mesangial cells in vitro Acta Pharmacol Sin. 37

3.) Ghada AK and J Golbahar. (2013) ?High Glucose-Induced Oxidative Stress Increases the Copy Number of Mitochondrial DNA in Human Mesangial Cells.? BioMed Research International. 2013: 1155-63 

4.) Kang MK, Lim SS, Lee JY, Yeo KM, Kang YH. (2013) "Anthocyanin-Rich Purple Corn Extract Inhibit Diabetes-Associated Glomerular Angiogenesis." PloS one. 8: e79823.

5.) Li J, Lim SS, Lee ES, Gong JH, Shin D, Kang IJ, Kang YH. (2011) "Isoangustone A suppresses mesangial fibrosis and inflammation in human renal mesangial cells."Exp Biol Med (Maywood). 236: 435-44.

6.) Wu F, Zhang W, Li L, Zheng F, Shao X, Zhou J, Li H. (2011) "Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells." Eur J Pharmacol. 654: 117-21.

7.) Huang P, Zhang Y, Jiang T, Zeng W, Zhang N. (2010) "Role of aldose reductase in the high glucose induced expression of fibronectin in human mesangial cells." Mol Biol Rep. 37: 3017-21.

8.) Li J, Kang SW, Kim JL, Sung HY, Kwun IS, Kang YH. (2010) "Isoliquiritigenin entails blockade of TGF-beta1-SMAD signaling for retarding high glucose-induced mesangial matrix accumulation." J Agric Food Chem. 58: 3205-12.

9.) Jiang T, Qu JJ, Nishinaka T, Zhang N. (2008) "Transcription factor AP-1 regulates TGF-beta(1)-induced expression of aldose reductase in cultured human mesangial cells." Nephrology (Carlton). 13: 212-7.

10.) Mathew JT, Patni H, Chaudhary AN, Liang W, Gupta A, Chander PN, Ding G, Singhal PC. (2008) "Aldosterone induces mesangial cell apoptosis both in vivo and in vitro."Am J Physiol Renal Physiol. 295: F73-81.

11.) Drel VR, Pacher P, Stevens MJ, Obrosova IG. (2006) "Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells." Free Radic Biol Med. 40: 1454-65. 

12.) Li Y, Wen X, Spataro BC, Hu K, Dai C, Liu Y. (2006) "Hepatocyte growth factor is a downstream effector that mediates the antifibrotic action of peroxisome proliferator-activated receptor-gamma agonists." J Am Soc Nephrol. 17: 54-65.

13.) Wen X, Li Y, Hu K, Dai C, Liu Y. (2005) "Hepatocyte growth factor receptor signaling mediates the anti-fibrotic action of 9-cis-retinoic acid in glomerular mesangial cells."Am J Pathol. 167: 947-57.

14.) Dai C, Liu Y. (2004) "Hepatocyte growth factor antagonizes the profibrotic action of TGF-beta1 in mesangial cells by stabilizing Smad transcriptional corepressor TGIF." J Am Soc Nephrol. 15: 1402-12.

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上海中乔新舟生物科技有限公司
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