上海中乔新舟生物科技有限公司

ScienCell's GeneQuery™ Human Hepatitis C qPCR Array Kit (GQH-HPC) is designed to facilitate gene expression profiling of 88 key genes involved in hepatitis C pathogenesis. Hepatitis C is a liver infectious disease caused by the Hepatitis C virus (HCV). The HCV exposure usually causes persistent liver infection and often develops into chronic liver disease. In response to hepatocyte HCV infection, antiviral immune response cascades are triggered and interferons are produced to modulate the immune system and suppress the spread of HCV. Brief examples of how included genes may be grouped are shown below:

HCV binding factor: LDLR, CD81, OCLN, SCARB1

Signaling pathways

RIG-1 like receptor: DDX58, MAVS, RAF3, TBK1, IKBKE, IRF3

Toll-like receptor: TLR3, TICAM1, RIPK1, IKBIB, IKBKG, CHUK

JAK/STAT: IFNAR1, IFNAR2, JAK1, TYK2, STAT1, STAT2, STAT6

Genes implicated in HCV infection: IFNA1, IFNA2, GPT, CLDN1, IFNB1, EIF2AK2, CLEC4M, RAF1, IRF3, HM13, GGT1

GeneQuery™ qPCR array kits are qPCR ready in a 96-well plate format, with each well containing one primer set that can specifically recognize and efficiently amplify a target gene's cDNA. The carefully designed primers ensure that: (i) the optimal annealing temperature in qPCR analysis is 65°C (with 2 mM Mg2+, and no DMSO); (ii) the primer set recognizes all known transcript variants of target gene, unless otherwise indicated; and (iii) only one gene is amplified. Each primer set has been validated by qPCR with melt curve analysis, and gel electrophoresis.

GeneQuery™ Human Hepatitis C qPCR Array Plate Layout*(8 controls in Bold and Italic)

AKT1

CLEC4M

EIF3E

IFNA2

IRF3

MAPK14

OAS1

PIK3R1

PPP2R1B

RIPK1

STAT6

β-actin

AKT2

DDX58

GGT1

IFNAR1

JAK1

MAPK3

OAS2

PIK3R2

PPP2R2A

RNASEL

TBK1

GAPDH

AKT3

EGFR

GPT

IFNAR2

LDLR

MAPK8

OAS3

PIK3R3

PPP2R2B

RXRA

TICAM1

LDHA

BAD

EIF2AK1

GRB2

IFNB1

MAPK1

MAPK9

OCLN

PIK3R5

PPP2R2C

SCARB1

TLR3

NONO

CD81

EIF2AK2

HM13

IKBKB

MAPK10

MAVS

PDPK1

PPARA

PPP2R2D

SOS1

TNFRSF1A

PPIH

CDKN1A

EIF2AK3

IFIT1

IKBKE

MAPK11

NFKB1

PIAS1

PPP2CA

PSME3

SOS2

TRADD

GDC

CHUK

EIF2AK4

IFIT1B

IKBKG

MAPK12

NFKBIA

PIK3CB

PPP2CB

RAF1

STAT1

TRAF2

PPC

CLDN1

EIF2S1

IFNA1

IRF1

MAPK13

NR1H3

PIK3CG

PPP2R1A

RELA

STAT2

TYK2

NTC

* gene selection may be updated based on new research and development

产品使用说明:仅供科研研究使用

货号	GK044
产地	美国
缩写	GQH-HPC
规格	One 96-well plate, one 20ul reaction per well
用途	科研
保存	4°C or -20°C
运输	常温

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