人主动脉内皮细胞HAEC

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3D细胞大规模培养》

人主动脉内皮细胞

英文名：Human Aortic Endothelial Cells
货号：6100
价格：￥13824.00

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人主动脉内皮细胞说明：

内皮细胞构成了血管和其下组织的交界面。内皮细胞功能的变化是动脉粥样硬化的发病机理中的关键因素。内皮细胞能合成分泌凝血系统和纤溶系统中的活化因子和抑制因子，同时也能合成和分泌影响着血小板粘附和聚集的某些介质。内皮细胞还可以释放具有调控细胞增殖和血管壁张力功能的分子。人主动脉内皮细胞能生成诸如t-PA 和PAI-1等抗凝和血栓形成因子；在TNF-alpha的调节下，人主动脉内皮细胞能改变其生长特性，产生GM-CSF等细胞因子，在细胞表面表达ICAM-1，并产生大量的NO和内皮素。许多内皮水平的过程多可以通过内皮细胞的体外培养进行研究，因此，HAEC非常适用于研究和认识血管病变和衰老的分子机理。

人主动脉内皮细胞(HAEC)提取于人主动脉组织，原代冻存。每管含有细胞数>5×105 cells/ml，此细胞通过vWF/Factor VIII 和CD31 (P-CAM)免疫荧光染色验证，经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。细胞可以达到15倍增。

推荐培养基:内皮细胞专用培养液 (ECM, Cat. No. 1001)

产品使用说明：仅供科研研究使用

货号	6100
产地	美国
缩写	HAEC
规格	5 x 10^5 cells/vial
用途	科研
运输	干冰
存储	液氮

1.) Zhu, D.D., Tang, R.N., Lv, L.L., Wen, Y., Liu, H., Zhang, X.L., Ma, K.L. & Liu, B.C. (2016) Interleukin-1? mediates high glucose induced phenotypic transition in human aortic endothelial cells Cardiovasc Diabetol. 15

2.) Zhao, Y., Zhang, X., Li, J., Bian, Y., Sheng, M., Liu, B., Fu, Z., Zhang, Y. & Yang, B. (2016) Jujuboside B Reduces Vascular Tension by Increasing Ca2+ Influx and Activating Endothelial Nitric Oxide Synthase PLoS One. 11

3.) Wu, W., Xu, H., Wang, Z., Mao, Y., Yuan, L., Luo, W., Cui, Z., Cui, T., Wang, X.L. & Shen, Y.H. (2015) PINK1-Parkin-Mediated Mitophagy Protects Mitochondrial Integrity and Prevents Metabolic Stress-Induced Endothelial Injury PLoS One. 10

4.) Pahl, M.C., Erdman, R., Kuivaniemi, H., Lillvis, J.H., Elmore, J.R. & Tromp, G. (2015) Transcriptional (ChIP-Chip) Analysis of ELF1, ETS2, RUNX1 and STAT5 in Human Abdominal Aortic Aneurysm Int J Mol Sci. 16

5.) Lin, S., Nadeau, P.E. & Mergia, A. (2015) HIV inhibits endothelial reverse cholesterol transport through impacting subcellular Caveolin-1 trafficking Retrovirology. 12

6.) Li, J., Zhou, J., Zhang, D., Song, Y., She, J. & Bai, C. (2015) Bone marrow-derived mesenchymal stem cells enhance autophagy via PI3K/AKT signalling to reduce the severity of ischaemia/reperfusion-induced lung injury J Cell Mol Med. 19

7.) Zhao N, Watson N, Xu Z, Chen Y, Waterman J, Sankar J, Zhu D. (2014) "In Vitro Biocompatibility and Endothelialization of Novel Magnesium-Rare Earth Alloys for Improved Stent Applications." PloS one. 9: e98674.

8.) Wang W, Deng M, Liu X, Ai W, Tang Q, Hu J. (2011) "TLR4 Activation Induces Nontolerant Inflammatory Response in Endothelial Cells." Inflammation. 34: 509-18.

9.) Cai W, Torreggiani M, Zhu L, Chen X, He JC, Striker GE, Vlassara H. (2010) "AGER1 regulates endothelial cell NADPH oxidase-dependent oxidant stress via PKC-delta: implications for vascular disease." Am J Physiol Cell Physiol. 298: C624-34.

10.) Kong DK, Georgescu SP, Cano C, Aronovitz MJ, Iovanna JL, Patten RD, Kyriakis JM, Goruppi S. (2010) "Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function." Mol Biol Cell. 21: 1335-49.

11.) Shahani T, Lavend'homme R, Luttun A, Saint-Remy JM, Peerlinck K, Jacquemin M. (2010) "Activation of human endothelial cells from specific vascular beds induces the release of a FVIII storage pool." Blood. 115: 4902-9.

12.) Zhang CL, Song F, Zhang J, Song QH. (2010) "Hypoxia-induced Bcl-2 expression in endothelial cells via p38 MAPK pathway." Biochem Biophys Res Commun. 394: 976-80.

13.) Linden E, Cai W, He JC, Xue C, Li Z, Winston J, Vlassara H, Uribarri J. (2008) "Endothelial dysfunction in patients with chronic kidney disease results from advanced glycation end products (AGE)-mediated inhibition of endothelial nitric oxide synthase through RAGE activation." Clin J Am Soc Nephrol. 3: 691-8.

14.) Zhang X, Baughman CB, Kaplan DL. (2008) "In vitro evaluation of electrospun silk fibroin scaffolds for vascular cell growth." Biomaterials. 29: 2217-27.

15.) Gentry M, Taormina J, Pyles RB, Yeager L, Kirtley M, Popov VL, Klimpel G, Eaves-Pyles T. (2007) "Role of Primary Human Alveolar Epithelial Cells in Host Defense against Francisella tularensis Infection." Infect Immun. 75: 3969-78.

16.) Simard JM, Tsymbalyuk O, Ivanov A, Ivanova S, Bhatta S, Geng Z, Woo SK, Gerzanich V. (2007) "Endothelial sulfonylurea receptor 1-regulated NCCa-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury." J Clin Invest. 117: 2105-13.

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