产品名称	U266B1[U266]人外周淋巴细胞
货号	ZQ0619
产品介绍	U266B1[U266]是由N.K.Nilsson于1970年从一名53岁患有IgE骨髓瘤男性的外周血中分离的B淋巴细胞。该细胞系的特征是分泌轻链和重链免疫球蛋白，主要是λ轻链和IgE重链。表现出典型的B淋巴细胞标记，已被广泛用于骨髓瘤生物学研究，特别是用于理解浆细胞恶性肿瘤和免疫反应的病理生理学机制。在药物发现和开发中的作用很有价值，为评估抗骨髓瘤药物的疗效提供了一个可靠的模型。它们也被用于研究骨髓瘤细胞与骨髓微环境的相互作用，这对于理解骨髓瘤的进展和对治疗的抗性是至关重要的。遗传学研究已经揭示了U266B1U266细胞中的几种染色体异常，这导致了它们的恶性表型和对凋亡的抵抗。该细胞系在多发性骨髓瘤分子靶向治疗的进展中发挥了重要作用。
种属	人
性别/年龄	男/53岁
组织	外周血
疾病	骨髓瘤
细胞类型	肿瘤细胞
形态学	成淋巴细胞
生长方式	悬浮
倍增时间	大约55~144小时
培养基和添加剂	RPMI-1640（ATCC改良款）（品牌：中乔新舟 货号：ZQ-200F）+15%胎牛血清（中乔新舟 货号：ZQ0500）+1%P/S（中乔新舟  货号：CSP006）
推荐完全培养基货号	ZM0619
生物安全等级	BSL-1
STR位点信息	Amelogenin: X,Y CSF1PO: 12,13 D13S317: 12 D16S539: 10 D5S818: 11,12 D7S820: 11,12 TH01: 5,7 TPOX: 8 vWA: 17 D3S1358: 17 D21S11: 28 D18S51: 12,14 Penta_E: 10,12 Penta_D: 10,13 D8S1179: 13 FGA: 18 D19S433: 13,15 D2S1338: 20,23
培养条件	95%空气，5%二氧化碳；37℃
抗原表达/受体表达	***
基因表达	***
保藏机构	ATCC; TIB-196 BCRC; 60437 DSMZ; ACC-9 ECACC; 85051003
供应限制	仅供科研使用

货号	ZQ0619
发货规格	活细胞：T25培养瓶*1瓶或者1ml 冻存管*1支（细胞量约为5 x 10^5 cells/vial）二选一
发货形式	活细胞：常温运输；冻存管：干冰运输
储存温度	活细胞：培养箱；冻存管：液氮罐
产地	中国
供应限制	仅供科研使用

论文标题： Globular C1q Receptor (gC1qR/p32/HABP1) Suppresses the Tumor-Inhibiting Role of C1q and Promotes Tumor Proliferation in 1q21-Amplified Multiple Myeloma
DOI： 10.3389/fimmu.2020.01292
发表时间： 2020-07-14
期刊： Frontiers in Immunology
影响因子： 5.085
货号： ZQ0619
产品名称： U266 cells

原文链接： https://www.frontiersin.org/articles/10.3389/fimmu.2020.01292/full

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