产品名称 |
BV-2小鼠小胶质细胞 |
货号 |
ZQ0397 |
产品介绍 |
BV-2细胞是由E·Blasi建立于1990年;此细胞源自C57BL/6小鼠小胶质细胞。表达核v-myc、染色体v-raf癌基因;膜表面表达envgp70抗原;在形态学、表型及功能上有吞噬细胞的特征;2n=57-66 。 注意事项:
BV2细胞冻存复苏细胞贴壁性差,基本处于悬浮细胞状态,细胞培养48小时后收集悬浮细胞和贴壁细胞,再次分瓶传代,细胞会呈现多边形贴壁细胞和悬浮细胞两种形态。 该细胞培养时松散贴壁,偶有漂浮,细胞形态对血清质量较为敏感。建议用户使用优质胎牛血清进行培养或选择订购配套BV2完全培养液。 |
种属 |
小鼠 |
组织来源 |
脑 |
形态学 |
上皮细胞样 |
细胞类型 |
转化细胞系 |
换液频率 |
2-3次/周 |
生长方式 |
半贴半悬 |
培养基和添加剂 |
MEM(中乔新舟 货号:ZQ-300)+10%FBS(品牌:中乔新舟 货号:ZQ0500)+1%P/S(中乔新舟 货号:CSP006)+1%Sodium Pyruvate 100 mM Solution(中乔新舟 货号:CSP003) |
推荐完全培养基货号 |
|
生物安全等级 |
BSL-2 |
培养条件 |
95%空气,5%二氧化碳;37℃ |
保藏机构 |
BCRJ; 0356 CCTCC; GDC0311 CLS; 305156 ICLC; ATL03001 KCB; KCB 200770YJ Ubigene; YC-C035 |
供应限制 |
仅供科研使用 |
货号 |
ZQ0397 |
发货规格 |
活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一 |
发货形式 |
活细胞:常温运输;冻存管:干冰运输 |
储存温度 |
活细胞:培养箱;冻存管:液氮罐 |
产地 |
中国 |
供应限制 |
仅供科研使用 |
论文标题: C1q/TNF-related protein 4 restores leptin sensitivity by downregulating NF-κB signaling and microglial activation
DOI: 10.1186/s12974-021-02167-2
发表时间: 2021-07-18
期刊: Journal of Neuroinflammation
影响因子: 8.322
货号: ZQ0397
产品名称: BV-2 microglial cells
原文链接: https://link.springer.com/article/10.1186/s12974-021-02167-2
论文标题: Chronic MC-LR exposure promoted Aβ and p-tau accumulation via regulating Akt/GSK-3β signal pathway
DOI: 10.1016/j.scitotenv.2021.148732
发表时间: 2021-06-29
期刊: SCIENCE OF THE TOTAL ENVIRONMENT
影响因子: 7.963
货号: ZQ0397
产品名称: BV-2 cells
原文链接: https://www.sciencedirect.com/science/article/pii/S0048969721038043
论文标题: Blood-brain barrier disruption and inflammation reaction in mice after chronic exposure to Microcystin-LR
DOI: 10.1016/j.scitotenv.2019.06.387
发表时间: 2019-06-26
期刊: SCIENCE OF THE TOTAL ENVIRONMENT
影响因子: 7.963
货号: ZQ0397
产品名称: BV-2 microglial cells
原文链接: https://www.sciencedirect.com/science/article/pii/S0048969719329602
论文标题: An image-based fingerprint-efficacy screening strategy for uncovering active compounds with interactive effects in Yindan Xinnaotong soft capsule
DOI: 10.1016/j.phymed.2021.153911
发表时间: 2021-12-26
期刊: PHYTOMEDICINE
影响因子: 5.34
货号: ZQ0397
产品名称: BV2 microglia cells
原文链接: https://www.sciencedirect.com/science/article/pii/S0944711321004517
论文标题: Hydrolyzed Chicken Meat Extract Attenuates Neuroinflammation and Cognitive Impairment in Middle-Aged Mouse by Regulating M1/M2 Microglial Polarization
DOI: 10.1021/acs.jafc.1c03541
发表时间: 2021-08-18
期刊: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
影响因子: 5.279
货号: ZQ0397
产品名称: mouse microglia BV2 cell line
原文链接: https://pubs.acs.org/doi/abs/10.1021/acs.jafc.1c03541
论文标题: CircPrkcsh, a circular RNA, contributes to the polarization of microglia towards the M1 phenotype induced by spinal cord injury and acts via the JNK/p38 MAPK pathway
DOI: 10.1096/fj.202100993R
发表时间: 2021-11-09
期刊: FASEB JOURNAL
影响因子: 5.192
货号: ZQ0397
产品名称: BV2 microglial cells
原文链接: https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.202100993R
论文标题: Curcumin protects against cognitive impairments in a rat model of chronic cerebral hypoperfusion combined with diabetes mellitus by suppressing neuroinflammation, apoptosis, and pyroptosis
DOI: 10.1016/j.intimp.2021.107422
发表时间: 2021-02-03
期刊: INTERNATIONAL IMMUNOPHARMACOLOGY
影响因子: 4.932
货号: ZQ0397
产品名称: Mouse BV2 microglial cells
原文链接: https://www.sciencedirect.com/science/article/pii/S1567576921000588
论文标题: 2,4-dichlorophenoxyacetic acid induces ROS activation in NLRP3 inflammatory body-induced autophagy disorder in microglia and the protective effect of Lycium barbarum polysaccharide
DOI: 10.1002/tox.23471
发表时间: 2022-01-31
期刊: ENVIRONMENTAL TOXICOLOGY
影响因子: 4.119
货号: ZQ0397
产品名称: BV2 microglial cells
原文链接: https://onlinelibrary.wiley.com/doi/abs/10.1002/tox.23471
论文标题: Laquinimod exerts anti-inflammatory and antiapoptotic effects in retinal ischemia/reperfusion injury
DOI: 10.1016/j.intimp.2020.106989
发表时间: 2020-09-18
期刊: INTERNATIONAL IMMUNOPHARMACOLOGY
影响因子: 3.943
货号: ZQ0397
产品名称: BV2 microglia
原文链接: https://www.sciencedirect.com/science/article/pii/S156757692031420X
论文标题: Dedicator of Cytokinesis 2 (DOCK2) Silencing Protects Against Cerebral Ischemia/Reperfusion by Modulating Microglia Polarization via the Activation of the STAT6 Signaling Pathway
DOI: 10.1016/j.neuroscience.2022.03.040
发表时间: 2022-04-05
期刊: NEUROSCIENCE
影响因子: 3.59
货号: ZQ0397
产品名称: BV-2 cells
原文链接: https://www.sciencedirect.com/science/article/pii/S0306452222001725
论文标题: Protective effect of scorpion venom heat-resistant synthetic peptide against PM2.5-induced microglial polarization via TLR4-mediated autophagy activating PI3K/AKT/NF-κB signaling pathway
DOI: 10.1016/j.jneuroim.2021.577567
发表时间: 2021-04-02
期刊: JOURNAL OF NEUROIMMUNOLOGY
影响因子: 3.478
货号: ZQ0397
产品名称: BV2 cells
原文链接: https://www.sciencedirect.com/science/article/pii/S0165572821000941
论文标题: Macelignan inhibits the inflammatory response of microglia and regulates neuronal survival
DOI: 10.1016/j.jneuroim.2019.577123
发表时间: 2019-12-10
期刊: JOURNAL OF NEUROIMMUNOLOGY
影响因子: 3.478
货号: ZQ0397
产品名称: BV2 microglia
原文链接: https://www.sciencedirect.com/science/article/pii/S0165572819305053
论文标题: Bioactive components of ethnomedicine Eerdun Wurile regulate the transcription of pro-inflammatory cytokines in microglia
DOI: 10.1016/j.jep.2019.112241
发表时间: 2019-09-15
期刊: JOURNAL OF ETHNOPHARMACOLOGY
影响因子: 3.414
货号: ZQ0397
产品名称: BV2 mouse microglial cell lines
原文链接: https://www.sciencedirect.com/science/article/pii/S037887411930488X
论文标题: Valproate improves middle cerebral artery occlusion-induced ischemic cerebral disorders in mice and oxygen-glucose deprivation-induced injuries in microglia by modulating RMRP/PI3K/Akt axis
DOI: 10.1016/j.brainres.2020.147039
发表时间: 2020-07-31
期刊: BRAIN RESEARCH
影响因子: 3.252
货号: ZQ0397
产品名称: BV-2 microglia
原文链接: https://www.sciencedirect.com/science/article/pii/S0006899320303978
论文标题: Walnut peptide WEKPPVSH in alleviating oxidative stress and inflammation in lipopolysaccharide-activated BV-2 microglia via the Nrf2/HO-1 and NF-κB/p38 MAPK pathways
DOI: 10.1016/j.jbiosc.2021.07.009
发表时间: 2021-09-09
期刊: JOURNAL OF BIOSCIENCE AND BIOENGINEERING
影响因子: 2.894
货号: ZQ0397
产品名称: BV-2 cell line
原文链接: https://www.sciencedirect.com/science/article/pii/S1389172321002024
论文标题: Resatorvid Relieves Breast Cancer Complicated with Depression by Inactivating Hippocampal Microglia Through TLR4/NF-κB/NLRP3 Signaling Pathway
DOI: 10.2147/CMAR.S279800
发表时间: 2020-12-18
期刊: Cancer Management and Research
影响因子: 2.886
货号: ZQ0397
产品名称: BV2 cell lines
原文链接: https://www.ncbi.nlm.nih.gov/pmc/articles/pmc7755376/
论文标题: Synergistic Regulation of Microglia Gene Expression by Natural Molecules in Herbal Medicine
DOI: 10.1155/2021/9920364
发表时间: 2021-08-19
期刊: Evidence-based Complementary and Alternative Medicine
影响因子: 2.63
货号: ZQ0397
产品名称: mouse BV2 microglial cell lines
原文链接: https://www.hindawi.com/journals/ecam/2021/9920364/
论文标题: Bakuchiol ameliorates cerebral ischemia-reperfusion injury by modulating NLRP3 inflammasome and Nrf2 signaling
DOI: 10.1016/j.resp.2021.103707
发表时间: 2021-06-01
期刊: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
影响因子: 1.931
货号: ZQ0397
产品名称: Mouse BV-2 microglia
原文链接: https://www.sciencedirect.com/science/article/pii/S1569904821000926
论文标题: Structure and properties of PVA/silk fibroin hydrogels and their effects on growth behavior of various cell types
DOI: 10.1088/2053-1591/ab69c4
发表时间: 2020-01-20
期刊: Materials Research Express
影响因子: 1.929
货号: ZQ0397
产品名称: BV2 microglial cells
原文链接: https://iopscience.iop.org/article/10.1088/2053-1591/ab69c4/meta
PubMed=2110186; DOI=10.1016/0165-5728(90)90073-V
Blasi E., Barluzzi R., Bocchini V., Mazzolla R., Bistoni F.
Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus.
J. Neuroimmunol. 27:229-237(1990)
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Henn A., Lund S., Hedtjarn M., Schrattenholz A., Porzgen P., Leist M.
The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation.
ALTEX 26:83-94(2009)
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Crain J.M., Watters J.J.
Estrogen and P2 purinergic receptor systems in microglia: therapeutic targets for neuroprotection.
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Atwood B.K., Lopez J., Wager-Miller J., Mackie K., Straiker A.
Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis.
BMC Genomics 12:14.1-14.14(2011)
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Stansley B., Post J., Hensley K.
A comparative review of cell culture systems for the study of microglial biology in Alzheimer's disease.
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Woo J.-M., Han D.-H., Park J.-H., Kim S.-J., Kim Y.-S.
In-depth characterization of the secretome of mouse CNS cell lines by LC-MS/MS without prefractionation.
Proteomics 15:3617-3622(2015)
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Mandal C., Yoon T., Park J.Y., Jung K.H., Chai Y.G.
Lipopolysaccharide-dependent transcriptional regulation of PU.1 in microglial cells.
Mol. Cell. Toxicol. 16:51-61(2020)
货号 | 产品名称 | 规格 | 价格 | 指令 |
R1900 | 大鼠小胶质细胞 | 5 x 10^5 cells/vial | ¥10728.00 | 放入购物车 》 |
M1900 | 小鼠小胶质细胞 | 5 x 10^5 cells/vial | ¥10944.00 | 放入购物车 》 |
M1900-57 | 小鼠小胶质细胞 | 1 x 10^6 cells/vial | ¥12852.00 | 放入购物车 》 |
1901 | 小胶质细胞培养基 | 500ML | ¥2320.00 | 放入购物车 》 |
1952 | 小胶质细胞生长因子 | 5ml | ¥1168.00 | 放入购物车 》 |
1904 | 人小胶质细胞cDNA | 20 reactions | ¥6552.00 | 放入购物车 》 |