产品名称	Capan-1人胰腺癌肿瘤细胞
货号	ZQ0955
产品介绍	Capan-1细胞系来源于人胰腺癌，是从一名40岁白人男性的腹水中建立的。该肿瘤于1975年首次被发现，其导管上皮形态与原发性胰腺肿瘤非常相似。Capan-1细胞被广泛用于研究胰腺癌生物学，包括肿瘤进展、转移和治疗耐药的研究。Capan-1表达囊性纤维化跨膜传导调节因子(CFTR)并分泌胃型粘蛋白。该细胞系因其产生黏液蛋白的能力而受到好评，黏液蛋白是许多胰腺腺癌的特征，因此可作为黏液性胰腺癌的模型。 从遗传学上讲，Capan-1包含KRAS基因突变，这是胰腺癌的典型特征，其他癌症相关基因如TP53和SMAD4也会发生突变。这些突变使Capan-1细胞系成为研究胰腺癌分子机制和针对这些途径的新治疗药物的临床前评估的有价值的工具。此外，Capan-1细胞被用于研究胰腺癌干细胞的生物学，为驱动癌症复发和对常规治疗的抵抗提供了见解。 Capan-1 细胞通常从冻存中恢复非常缓慢，可能需要一周以上的时间才能使细胞很好地附着并生长到足以进行传代培养。
种属	人
性别/年龄	男/40岁
组织	胰腺；来源于转移部位:肝脏
疾病	腺癌
细胞类型	肿瘤细胞
形态学	上皮样
生长方式	贴壁
倍增时间	60-80 hours (CLS=300143); ~50-100 hours (DSMZ=ACC-244); ~49 hours (PBCF)
培养基和添加剂	IMDM（中乔新舟    货号：ZQ-900）+20%FBS（中乔新舟    货号：ZQ0500）+1%P/S（中乔新舟   货号：CSP006）
推荐完全培养基货号	ZM0955
生物安全等级	BSL-1
STR位点信息	Amelogenin: X CSF1PO: 11 D13S317: 9 D16S539: 13,14 D5S818: 11 D7S820: 10,11 THO1: 6 TPOX: 8,11 vWA: 16
培养条件	95%空气，5%二氧化碳；37℃
抗原表达/受体表达	***
基因表达	***
保藏机构	ATCC; HTB-79 BCRJ; 0265 KCLB; 30079
供应限制	仅供科研使用

货号	ZQ0955
发货规格	活细胞：T25培养瓶*1瓶或者1ml 冻存管*1支（细胞量约为5 x 10^5 cells/vial）二选一
发货形式	活细胞：常温运输；冻存管：干冰运输
储存温度	活细胞：培养箱；冻存管：液氮罐
产地	中国
供应限制	仅供科研使用

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