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MHCC97-H人肝癌细胞(高转)(STR鉴定)[套餐促销]

英文名:MHCC97-H
货号:ZQ0020
价格:¥1350.00
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MHCC97-H人肝癌细胞(高转)(STR鉴定)[套餐促销]

¥1350.00
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MHCC97-H人肝癌细胞(高转)专用培养基

¥350.00 ¥480.00

配套完培,省时省力,单买细胞无优惠

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细胞套餐惊爆价

¥1700 ¥2380
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  • 产品说明
  • 产品规格
  • 参考文献
  • STR鉴定

产品名称

MHCC97-H人肝癌细胞(高转)

货号

ZQ0020

产品介绍

MHCC97-H是一种人肝癌细胞系,具有高度的转移潜能。它源自复旦大学中山医院肝癌研究所通过对人肝癌细胞株MHCC97进行多次肺转移筛选后建立的细胞系,取自39岁男性肝癌患者的肺转移瘤。MHCC97-H细胞系在肝癌发病机理的基础研究、临床研究以及抗肿瘤药物筛选中有着广泛的应用。该细胞系的建立为肝癌的研究提供了重要的实验材料,有助于深入理解肝癌的转移机制以及开发新的治疗策略。

复旦大学中山医院肝癌研究所在研究MHCC97时发现其是异质性很强的细胞群。部分细胞有很强的致瘤性和转移力,而部分则较弱。因此分离建立了高低转移性不同的肝癌细胞株MHCC97-H和MHCC97-L。据报道MHCC97-H存在较高的干细胞样的侧群细胞(sp)。肝癌SP细胞具有极高的致瘤性,并可能和肝癌转移潜能相关。后再用人肝癌细胞株MHCC97-H接种裸鼠,进行3次肺转移筛选,取肺转移瘤建成皮下接种后高度自发性肺转移的肝癌细胞系MHCC97-LM3。

种属

性别/年龄

男/39岁

组织

疾病

肝癌

生物安全等级

BSL-1

STR位点信息

Amelogenin:X,Y;

CSF1PO: 11,13;

D5S818:12,13;

D7S820:10;

D13S317:8,11.3;

D16S539:12;

TH01:9;

TPOX:8;

vWA:14;

细胞类型

 肿瘤细胞

形态学

上皮细胞样

生长方式

贴壁

倍增时间

~28.79小时

培养基和添加剂

DMEM高糖(中乔新舟 货号:ZQ-100+10%胎牛血清(中乔新舟 货号:ZQ0500)+1%双抗(货号:CSP006

推荐完全培养基货号

ZM0020

培养条件

95%空气,5%二氧化碳;37℃

抗原表达/受体表达

*** 

基因表达

*** 

细胞来源

国内机构

供应限制

仅供科研使用

货号

ZQ0020

发货规格

活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一

发货形式

活细胞:常温运输;冻存管:干冰运输

储存温度

活细胞:培养箱;冻存管:液氮罐

产地

中国

供应限制

仅供科研使用


1、论文标题: Triple-serotype chimeric oncolytic adenovirus exerts multiple synergistic mechanisms against solid tumors
DOI: 10.1136/jitc-2022-004691
发表时间: 2022-05-01
期刊: Journal for ImmunoTherapy of Cancer
影响因子: 13.751
货号: ZQ0020
产品名称: MHCC97H cells
原文链接: https://jitc.bmj.com/content/10/5/e004691.abstract


2、论文标题: EFNA4 promotes cell proliferation and tumor metastasis in hepatocellular carcinoma through a PIK3R2/GSK3β/β-catenin positive feedback loop
DOI: 10.1016/j.omtn.2021.06.002
发表时间: 2021-06-12
期刊: Molecular Therapy-Nucleic Acids
影响因子: 8.886
货号: ZQ0020
产品名称: MHCC-97H cells
原文链接: https://www.sciencedirect.com/science/article/pii/S2162253121001438


3、论文标题: EGFR/MET promotes hepatocellular carcinoma metastasis by stabilizing tumor cells and resisting to RTKs inhibitors in circulating tumor microemboli
DOI: 10.1038/s41419-022-04796-8
发表时间: 2022-04-15
期刊: Cell Death & Disease
影响因子: 8.469
货号: ZQ0020
产品名称: MHCC-97H cells
原文链接: https://www.nature.com/articles/s41419-022-04796-8


4、论文标题: DNA primase subunit 1 deteriorated progression of hepatocellular carcinoma by activating AKT/mTOR signaling and UBE2C-mediated P53 ubiquitination
DOI: 10.1186/s13578-021-00555-y
发表时间: 2021-02-23
期刊: Cell and Bioscience
影响因子: 7.133
货号: ZQ0020
产品名称: MHCC97H cells
原文链接: https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-021-00555-y


5、论文标题: COE Inhibits Vasculogenic Mimicry by Targeting EphA2 in Hepatocellular Carcinoma, a Research Based on Proteomics Analysis
DOI: 10.3389/fphar.2021.619732
发表时间: 2021-03-31
期刊: Frontiers in Pharmacology
影响因子: 5.811
货号: ZQ0020
产品名称: MHCC97-H cells
原文链接: https://www.frontiersin.org/articles/10.3389/fphar.2021.619732/full


6、论文标题: HOXD3 was negatively regulated by YY1 recruiting HDAC1 to suppress progression of hepatocellular carcinoma cells via ITGA2 pathway
DOI: 10.1111/cpr.12835
发表时间: 2020-06-17
期刊: CELL PROLIFERATION
影响因子: 5.753
货号: ZQ0020
产品名称: MHCC-97H cells
原文链接: https://onlinelibrary.wiley.com/doi/abs/10.1111/cpr.12835


7、论文标题: Oncogenic tuftelin 1 as a potential molecular-targeted for inhibiting hepatocellular carcinoma growth
DOI: 10.3748/wjg.v27.i23.3327
发表时间: 2021-06-21
期刊: WORLD JOURNAL OF GASTROENTEROLOGY
影响因子: 5.742
货号: ZQ0020
产品名称: MHCC-97H cells
原文链接: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218352/


8、论文标题: Glycopattern Alteration of Glycoproteins in Gastrointestinal Cancer Cell Lines and Their Cell-Derived Exosomes
DOI: 10.1021/acs.jproteome.2c00159
发表时间: 2022-07-05
期刊: JOURNAL OF PROTEOME RESEARCH
影响因子: 5.37
货号: ZQ0020
产品名称: MHCC-97H cells
原文链接: https://pubs.acs.org/doi/abs/10.1021/acs.jproteome.2c00159


9、论文标题: Fuzheng Jiedu Xiaoji formulation inhibits hepatocellular carcinoma progression in patients by targeting the AKT/CyclinD1/p21/p27 pathway
DOI: 10.1016/j.phymed.2021.153575
发表时间: 2021-04-18
期刊: PHYTOMEDICINE
影响因子: 5.34
货号: ZQ0020
产品名称: MHCC97H cells

原文链接: https://www.sciencedirect.com/science/article/pii/S0944711321001173


10、论文标题: SRXN1 stimulates hepatocellular carcinoma tumorigenesis and metastasis through modulating ROS/p65/BTG2 signalling
DOI: 10.1111/jcmm.15693
发表时间: 2020-08-03
期刊: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
影响因子: 4.486
货号: ZQ0020
产品名称: MHCC-97H cells
原文链接: https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.15693


11、论文标题: MARCH6 promotes hepatocellular carcinoma development through up-regulation of ATF2
DOI: 10.1186/s12885-021-08540-x
发表时间: 2021-07-17
期刊: BMC CANCER
影响因子: 4.43
货号: ZQ0020
产品名称: MHCC97H cells
原文链接: https://link.springer.com/article/10.1186/s12885-021-08540-x


12、论文标题: Positive feedback loop of FAM83A/PI3K/AKT/c-Jun induces migration, invasion and metastasis in hepatocellular carcinoma
DOI: 10.1016/j.biopha.2019.109780
发表时间: 2019-12-31
期刊: BIOMEDICINE & PHARMACOTHERAPY
影响因子: 3.743
货号: ZQ0020
产品名称: MHCC-97H cells
原文链接: https://www.sciencedirect.com/science/article/pii/S0753332219354022


13、论文标题: Low expression of long noncoding RNA CTC-297N7.9 predicts poor prognosis in patients with hepatocellular carcinoma
DOI: 10.1002/cam4.2618
发表时间: 2019-11-01
期刊: Cancer Medicine
影响因子: 3.357
货号: ZQ0020
产品名称: MHCC-97H cells
原文链接: https://onlinelibrary.wiley.com/doi/abs/10.1002/cam4.2618


14、论文标题: Linc00601 upregulation promotes hepatocellular carcinoma development by activating MAPK signaling pathway
DOI: 10.26355/eurrev_202006_21498
发表时间: 2020-06-01
期刊: European Review for Medical and Pharmacological Sciences
影响因子: 3.024
货号: ZQ0020
产品名称: MHCC97-H cells
原文链接: https://pubmed.ncbi.nlm.nih.gov/32572918/


15、论文标题: COE inhibits vasculogenic mimicry in hepatocellular carcinoma via suppressing Notch1 signaling
DOI: 10.1016/j.jep.2017.07.007
发表时间: 2017-07-08
期刊: JOURNAL OF ETHNOPHARMACOLOGY
影响因子: 2.981
货号: ZQ0020
产品名称: MHCC97-H cells
原文链接: https://www.sciencedirect.com/science/article/pii/S0378874116317640


16、论文标题: RNA sequencing identifies two novel liver-specific long noncoding RNAs with potential diagnostic value in hepatocellular carcinoma
DOI: 10.2217/bmm-2020-0825
发表时间: 2021-06-15
期刊: Biomarkers in Medicine
影响因子: 2.851
货号: ZQ0020
产品名称: MHCC97-H cells
原文链接: https://www.futuremedicine.com/doi/abs/10.2217/bmm-2020-0825


17、论文标题: FK866 inhibits the epithelial‑mesenchymal transition of hepatocarcinoma MHCC97‑H cells
DOI: 10.3892/ol.2018.9541
发表时间: 2018-10-03
期刊: Oncology Letters
影响因子: 1.664
货号: ZQ0020
产品名称: human liver tumor cell line MHCC97-H

原文链接: https://www.spandidos-publications.com/10.3892/ol.2018.9541



PubMed=11819844; DOI=10.3748/wjg.v7.i5.630; PMCID=PMC4695564
Li Y., Tang Z.-Y., Ye S.-L., Liu Y.-K., Chen J., Xue Q., Chen J., Gao D.-M., Bao W.-H.
Establishment of cell clones with different metastatic potential from the metastatic hepatocellular carcinoma cell line MHCC97.
World J. Gastroenterol. 7:630-636(2001)


PubMed=15048980; DOI=10.1002/pmic.200300653
Ding S.-J., Li Y., Shao X.-X., Zhou H., Zeng R., Tang Z.-Y., Xia Q.-C.
Proteome analysis of hepatocellular carcinoma cell strains, MHCC97-H and MHCC97-L, with different metastasis potentials.
Proteomics 4:982-994(2004)


PubMed=15146329; DOI=10.1007/s00432-004-0564-9
Li Y., Tian B., Yang J., Zhao L., Wu X., Ye S.-L., Liu Y.-K., Tang Z.-Y.
Stepwise metastatic human hepatocellular carcinoma cell model system with multiple metastatic potentials established through consecutive in vivo selection and studies on metastatic characteristics.
J. Cancer Res. Clin. Oncol. 130:460-468(2004)


PubMed=23505090; DOI=10.1002/hep.26402
Wang K., Lim H.Y., Shi S., Lee J., Deng S.-B., Xie T., Zhu Z., Wang Y.-L., Pocalyko D., Yang W.J., Rejto P.A., Mao M., Park C.-K., Xu J.-C.
Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma.
Hepatology 58:706-717(2013)


PubMed=25690035; DOI=10.3390/ijms16024209; PMCID=PMC4346953
Tian M.-M., Cheng H., Wang Z.-Q., Su N., Liu Z.-X., Sun C.-Q., Zhen B., Hong X.-C., Xue Y., Xu P.
Phosphoproteomic analysis of the highly-metastatic hepatocellular carcinoma cell line, MHCC97-H.
Int. J. Mol. Sci. 16:4209-4225(2015)


PubMed=25886575; DOI=10.1186/s12885-015-1166-4; PMCID=PMC4380258
Dang H., Steinway S.N., Ding W., Rountree C.B. Jr.
Induction of tumor initiation is dependent on CD44s in c-Met(+) hepatocellular carcinoma.
BMC Cancer 15:161.1-161.11(2015)


PubMed=31063779; DOI=10.1053/j.gastro.2019.05.001
Caruso S., Calatayud A.-L., Pilet J., La Bella T., Rekik S., Imbeaud S., Letouze E., Meunier L., Bayard Q., Rohr-Udilova N., Peneau C., Grasl-Kraupp B., de Koning L., Ouine B., Bioulac-Sage P., Couchy G., Calderaro J., Nault J.-C., Zucman-Rossi J., Rebouissou S.
Analysis of liver cancer cell lines identifies agents with likely efficacy against hepatocellular carcinoma and markers of response.
Gastroenterology 157:760-776(2019)


PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001; PMCID=PMC7505724
Qiu Z.-X., Li H., Zhang Z.-T., Zhu Z.-F., He S., Wang X.-J., Wang P.-C., Qin J.-J., Zhuang L.-P., Wang W., Xie F.-B., Gu Y., Zou K.-K., Li C., Li C., Wang C.-H., Cen J., Chen X.-T., Shu Y.-J., Zhang Z., Sun L.-L., Min L.-H., Fu Y., Huang X.-W., Lv H., Zhou H., Ji Y., Zhang Z.-G., Meng Z.-Q., Shi X.-L., Zhang H.-B., Li Y.-X., Hui L.-J.
A pharmacogenomic landscape in human liver cancers.
Cancer Cell 36:179-193.e11(2019)


PubMed=32884988; DOI=10.1016/j.gendis.2019.12.008; PMCID=PMC7452459
Lin Y.-L., Li Y.
Study on the hepatocellular carcinoma model with metastasis.
Genes Dis. 7:336-350(2020)



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