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Karpas422人非霍奇金淋巴瘤细胞 (STR鉴定)

英文名:Karpas422
货号:ZQ1049
价格:¥4380.00
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Karpas422人非霍奇金淋巴瘤细胞 (STR鉴定)

¥4380.00
+

Karpas422人非霍奇金淋巴瘤细胞专用培养基

¥650.00

配套完培,省时省力,单买细胞无优惠

=

细胞套餐惊爆价

¥5030
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  • 产品说明
  • 产品规格
  • 参考文献
  • STR鉴定

产品名称

Karpas422人非霍奇金淋巴瘤细胞

货号

ZQ1049

产品介绍

Karpas422细胞建立于73岁女性胸膜积液,诊断为b细胞非霍奇金淋巴瘤(腹腔内弥漫性大细胞淋巴瘤,难治性,终末期)。Karpas422细胞系在淋巴瘤研究领域具有重要价值,可用于研究B细胞淋巴瘤的发病机制、药物筛选和免疫治疗等方面的研究。该细胞系还可以用于开发新型的免疫疗法和疫苗,以治疗和预防B细胞淋巴瘤。

种属

性别/年龄

/73岁

组织

B细胞淋巴瘤

疾病

B细胞非霍奇金淋巴瘤

细胞类型

肿瘤细胞

形态学

圆形多角形细胞,单个或小簇悬浮生长

生长方式

悬浮

倍增时间

~60-90 hours (ECACC=06101702; Ximbio=152419)

培养基和添加剂

RPMI-1640(品牌:中乔新舟 货号:ZQ-200+20%胎牛血清(中乔新舟 货号:ZQ0500+1%P/S(中乔新舟  货号:CSP006

推荐完全培养基货号

ZM1049

培养条件

95%空气,5%二氧化碳;37℃

STR位点信息

Amelogenin: X

CSF1PO: 10,11

D2S1338 :19,20

D3S1358: 15,18

D5S818 :11,12

D7S820 :12,13

D8S1179 11,15

D13S317 12

D16S539 13

D18S51 12,14

D19S433 14,16

D21S11 29 (DSMZ=ACC-32)

             :29,32.2 (PubMed=25877200)

FGA 23,27

Penta D 9,12

Penta E 7,17

TH01 6,9

TPOX 8

vWA 19

生物安全等级

BSL-1

保藏机构

ECACC; 06101702

供应限制

仅供科研使用


货号

ZQ1049

发货规格

活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一

发货形式

活细胞:常温运输;冻存管:干冰运输

储存温度

活细胞:培养箱;冻存管:液氮罐

产地

中国

供应限制

仅供科研使用

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A new human B-cell non-Hodgkin's lymphoma cell line (Karpas 422) exhibiting both t (14;18) and t(4;11) chromosomal translocations.
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PubMed=12169673; DOI=10.1016/S1525-1578(10)60693-9
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Microarray analysis of B-cell lymphoma cell lines with the t(14;18).
J. Mol. Diagn. 4:123-136(2002)


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Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
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PubMed=19278952; DOI=10.1182/blood-2009-01-202028
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Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma.
Blood 113:6681-6690(2009)


PubMed=19358282; DOI=10.1002/ijc.24351
Inagaki A., Ishida T., Yano H., Ishii T., Kusumoto S., Ito A., Ri M., Mori F., Ding J.-M., Komatsu H., Iida S., Ueda R.
Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.
Int. J. Cancer 125:212-221(2009)


PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)


PubMed=20628145; DOI=10.1182/blood-2010-05-282780
Green M.R., Monti S., Rodig S.J., Juszczynski P., Currie T., O'Donnell E., Chapuy B., Takeyama K., Neuberg D., Golub T.R., Kutok J.L., Shipp M.A.
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.
Blood 116:3268-3277(2010)


PubMed=23257783; DOI=10.1038/leu.2012.367
Wenzel S.-S., Grau M., Mavis C., Hailfinger S., Wolf A., Madle H., Deeb G., Dorken B., Thome M., Lenz P., Dirnhofer S., Hernandez-Ilizaliturri F.J., Tzankov A., Lenz G.
MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma.
Leukemia 27:1381-1390(2013)


PubMed=23292937; DOI=10.1073/pnas.1205299110
Zhang J., Grubor V., Love C.L., Banerjee A., Richards K.L., Mieczkowski P.A., Dunphy C., Choi W., Au W.Y., Srivastava G., Lugar P.L., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P., Flowers C.R., Naresh K., Evens A.M., Gordon L.I., Czader M.B., Gill J.I., Hsi E.D., Liu Q.-Q., Fan A., Walsh K., Jima D., Smith L.L., Johnson A.J., Byrd J.C., Luftig M.A., Ni T., Zhu J., Chadburn A., Levy S., Dunson D.B., Dave S.S.
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Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013)


PubMed=23699601; DOI=10.1182/blood-2013-02-483727
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Blood 122:1256-1265(2013)


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A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
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PubMed=25355872; DOI=10.1128/JVI.02570-14
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High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
J. Virol. 89:713-729(2015)


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PubMed=25877200; DOI=10.1038/nature14397
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Quantitative proteomics of the Cancer Cell Line Encyclopedia.
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Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022

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