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人淋巴内皮细胞
英文名:Human Lymphatic Endothelial Cells
货号:2500
价格:¥13570.00
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人淋巴内皮细胞描述:

       

       淋巴系统是免疫系统的重要部分,与血管系统共同作用来保持组织的内环境稳定。淋巴系统从组织中得到液体和大分子物质并将其返回血液循环,因此,淋巴系统在调节组织中液体,蛋白质和压力平衡方面起着重要作用。尽管淋巴毛细管内皮细胞与血管内皮有许多相似的特性,但由于结构不同,又各具特点。淋巴毛细管缺少壁细胞且以基底膜不完整或缺失为特征。淋巴内皮的特征是包含大量的内褶和细胞质囊泡,并且具有交错的细胞间连接。淋巴毛细管最显著的特征是与间质的一体化,间质通过细微的弹性纤维与细胞外基质相连。   

 

       人淋巴内皮细胞 (HLEC)提取于人淋巴结组织,原代冻存。每管含有细胞数>5×10 5cells/ml,此细胞通过vWF/Factor VIII 和CD31 (P-CAM)免疫荧光染色验证,经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。细胞可以达到10倍增。


配套培养基: 内细胞培养基:(ECM, Cat. No. 1001)

产品使用说明:仅供科研研究使用

货号 2500
产地 美国
缩写 HLEC
规格 5 x 10^5 cells/vial
用途 科研
运输 干冰
保存 液氮

1.) Speyer CL, Hachem AH, Assi AA, Johnson JS, DeVries JA, Gorski DH. (2014) "Metabotropic Glutamate Receptor-1 as a Novel Target for the Antiangiogenic Treatment of Breast Cancer." PloS one. 9: e88830.


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8.) Zhuang Z, Jian P, Longjiang L, Bo H, Wenlin X. (2010) "Altered phenotype of lymphatic endothelial cells induced by highly metastatic OTSCC cells contributed to the lymphatic metastasis of OTSCC cells." Cancer Sci. 101: 686-92. 

 9.) Wen J, Fu AF, Chen LJ, Xie XJ, Yang GL, Chen XC, Wang YS, Li J, Chen P, Tang MH, Shao XM, Lu Y, Zhao X, Wei YQ. (2009) "Liposomal honokiol inhibits VEGF-D-induced lymphangiogenesis and metastasis in xenograft tumor model." Int J Cancer. 124: 2709-18. 

10.) Thapa N, Hong HY, Sangeetha P, Kim IS, Yoo J, Rhee K, Oh GT, Kwon IC, Lee BH. (2008) "Identification of a peptide ligand recognizing dysfunctional endothelial cells for targeting atherosclerosis." J Control Release. 131: 27-33. 

11.) Yoon CM, Hong BS, Moon HG, Lim S, Suh PG, Kim YK, Chae CB, Gho YS. (2008) "Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways." Blood. 112: 1129-38.

 12.) Zhuang Z, Jian P, Longjiang L, Bo H, Hongwei Z. (2008) "Identification of oral cancer cell-induced changes in gene expression profile of lymphatic endothelial cell."Cancer Invest. 26: 1002-7.
Question:
Do these express podoplanin

Answers:

Posted by Manoj Sharma on Thursday, January 14, 2016

Our quality control department does not test for podoplanin expression in Human Lymphatic Endothelial Cells. We do test for endothelial cell markers CD-31 and Factor VIII.

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