产品名称 |
IOMM-Lee 人脑膜瘤细胞 |
货号 |
ZQ1065 |
产品介绍 |
IOMM-Lee是一株上皮样细胞系,从61岁男性脑膜瘤患者的幕状脑中分离出来。它在神经科学研究中也有应用。IOMM-Lee细胞系为研究脑膜瘤提供了一个有价值的模型系统,有助于科学家们更好地理解这种疾病并开发新的治疗方法。通过使用这些细胞系,研究人员可以进行各种实验,包括基因表达分析、药物敏感性测试和信号传导研究,以推动对脑膜瘤的理解和治疗进展。 |
种属 |
人 |
性别/年龄 |
男/61岁 |
组织 |
脑 |
疾病 |
脑膜瘤 |
细胞类型 |
肿瘤细胞 |
形态学 |
上皮 |
生长方式 |
贴壁 |
倍增时间 |
~62 hours (PubMed=2234331); 18 hours (PubMed=25984343); 0.8 day (PubMed=34850056); ~22 hours (ATCC=CRL-3370) |
培养基和添加剂 |
DMEM (中乔新舟 货号:ZQ-100)+10%胎牛血清(中乔新舟 货号:ZQ500-A)+1%P/S(中乔新舟 货号:CSP006) |
推荐完全培养基货号 |
|
生物安全等级 |
BSL-1 |
培养条件 |
95%空气,5%二氧化碳;37℃ |
STR位点信息 |
Amelogenin: X CSF1PO: 9,10 D5S818: 11,13 D7S820 :11,12 D13S317: 8,9 D16S539: 12,13 TH01: 6,7 TPOX: 8,11 vWA :17,18 |
抗原表达/受体表达 |
*** |
基因表达 |
*** |
保藏机构 |
ATCC; CRL-3370 |
供应限制 |
仅供科研使用 |
货号 |
ZQ1065 |
发货规格 |
活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一 |
发货形式 |
活细胞:常温运输;冻存管:干冰运输 |
储存温度 |
活细胞:培养箱;冻存管:液氮罐 |
产地 |
中国 |
供应限制 |
仅供科研使用 |
PubMed=2234331; DOI=10.1097/00006123-199009000-00008
Lee W.-H.
Characterization of a newly established malignant meningioma cell line of the human brain: IOMM-Lee.
Neurosurgery 27:389-395(1990)
PubMed=16554968; DOI=10.1007/s11060-005-9076-y
Baia G.S., Slocum A.L., Hyer J.D., Misra A., Sehati N., VandenBerg S.R., Feuerstein B.G., Deen D.F., McDermott M.W., Lal A.
A genetic strategy to overcome the senescence of primary meningioma cell cultures.
J. Neurooncol. 78:113-121(2006)
PubMed=18261772; DOI=10.1016/j.surneu.2007.06.031
Ragel B.T., Couldwell W.T., Gillespie D.L., Wendland M.M., Whang K., Jensen R.L.
A comparison of the cell lines used in meningioma research.
Surg. Neurol. 70:295-307(2008)
PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)
PubMed=28552950; DOI=10.1371/journal.pone.0178322
Mei Y., Bi W.-Y.L., Greenwald N.F., Agar N.Y.R., Beroukhim R., Dunn G.P., Dunn I.F.
Genomic profile of human meningioma cell lines.
PLoS ONE 12:E0178322-E0178322(2017)
PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)
PubMed=34850056; DOI=10.1093/jnen/nlab111
Uhlmann E.J., Rabinovsky R., Varma H., El Fatimy R., Kasper E.M., Moore J.M., Vega R.A., Thomas A.J., Alterman R.L., Stippler M., Anderson M.P., Uhlmann E.N., Kipper F.C., Krichevsky A.M.
Tumor-derived cell culture model for the investigation of meningioma biology.
J. Neuropathol. Exp. Neurol. 80:1117-1124(2021)