产品名称	MDA-PCA-2B人前列腺癌细胞
货号	ZQ1072
产品介绍	MDA PCa 2b 是一种表现出上皮样形态的细胞系，从一名 63 岁黑人男性腺癌患者的前列腺中分离出来。该细胞系由 NM Navone 保藏。MDA-PCA-2B细胞系可用于前列腺癌的研究，特别是在药物开发和转移机制研究方面。此外，这些细胞系也可用于研究种族差异相关的前列腺癌，因为它们来自非裔美国患者。 MDA-PCA-2B细胞可能携带一些特定的基因突变，这些突变在前列腺癌的发展中起关键作用，如PTEN、SMAD4、NKX3.1、MYC等。 MDA-PCA-2B细胞系还可以用于研究前列腺癌对雄激素剥夺治疗(ADT)的耐药性，因为它们能够在雄激素剥夺后形成新的亚系，如MDA-PCA-2B-hr。 这些特性使得MDA-PCA-2B细胞系成为研究前列腺癌的重要工具，尤其是在药物开发和转移机制研究方面。
种属	人
性别/年龄	男/63岁
组织	骨
疾病	前列腺癌
细胞类型	肿瘤细胞
形态学	上皮
生长方式	贴壁
倍增时间	42-53 hours (Note=In BRFF-HPC1 + 20% FBS), 61-73 hours (Note=In F12K(+) + 20% FBS) (PubMed=9815652); 89.15 hours (JWGray panel)
培养基和添加剂	F-12K基础培养基（ZQ-599）+20%胎牛血清（中乔新舟  货号：ZQ500-A）+1%P/S（中乔新舟  货号：CSP006）+25 ng/ml cholera toxin,+10 ng/ml Epidermal Growth Factor,+0.005 mM phosphoethanolamine,+100 pg/ml hydrocortisone, 45 nM sodium selenite,+0.005 mg/ml human recombinant insulin
推荐完全培养基货号	zm1072
生物安全等级	BSL-1
培养条件	95%空气，5%二氧化碳；37℃
STR位点信息	Amelogenin ：X,Y CSF1PO： 10,12 D2S1338： 22,24 D3S1358： 14,17 D5S818： 12,13 D7S820： 8,10 D8S1179 ：14,15 D13S317： 11,12 D16S539： 10,11 D18S51： 16,17 D19S433： 13.2,14.2,16 D21S11： 33.2 FGA ：20,21,22 (ATCC=CRL-2422)         ：20,22 (PubMed=14518029) Penta D ：11,13 Penta E：8,14 TH01： 8,9 TPOX： 8,11 vWA ：16
抗原表达/受体表达	***
基因表达	***
保藏机构	ATCC; CRL-2422
供应限制	仅供科研使用

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