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MOLT-3人急性T淋巴细胞白血病细胞

英文名:MOLT-3
货号:ZQ1165
价格:¥5500.00
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MOLT-3人急性T淋巴细胞白血病细胞

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  • 产品说明
  • 产品规格
  • 参考文献
  • STR鉴定

产品名称

MOLT-3人急性T淋巴细胞白血病细胞

货号

ZQ1165

产品介绍

MOLT-3是一种人急性T淋巴细胞白血病细胞系,它与MOLT-4细胞系一样,来源于一名19岁的男性急性淋巴细胞性白血病复发患者的外周血,该患者之前接受过多种药物联合化疗,特别是在先前化疗后的复发期间,稳定的 T 细胞白血病系。该细胞系由J. Minowada博士保藏,MOLT-3细胞广泛用于免疫系统疾病、免疫学和免疫肿瘤学的研究,使其成为研究T细胞白血病和对各种治疗的免疫反应的重要模型。


作为悬浮细胞系,MOLT-3表现出典型的T细胞标记,包括CD5 (97%)和CD7 (97%)以及CD1和CD4的高表达。该细胞系的特征还在于末端脱氧核苷酸转移酶(TdT)活性升高,这通常与未成熟淋巴样细胞有关。MOLT-3对于研究T细胞分化、受体信号传导和凋亡是有价值的,特别是在T细胞急性淋巴细胞白血病(T-ALL)的背景下。由于其生长特性和充分表征的抗原表达,它经常用于白血病治疗的药物筛选和治疗研究。

此外,MOLT-3细胞不产生免疫球蛋白或含有可检测的爱泼斯坦-巴尔病毒(EBV),这使它们成为研究T细胞特异性途径而不受B细胞特征干扰的极好模型。该细胞系对各种实验操作的响应进一步增强了其在免疫肿瘤学中的应用,特别是用于探索针对T细胞恶性肿瘤的潜在治疗干预。
可以帮助科学家们理解疾病的发病机制、药物筛选和新的治疗方法的开发。

种属

性别/年龄

男/19岁

组织

外周血

疾病

急性淋巴细胞白血病

细胞类型

肿瘤细胞

形态学

淋巴样细胞

生长方式

悬浮

倍增时间

大约24~48 小时

培养基和添加剂

RPMI-1640(品牌:中乔新舟 货号:ZQ-200+10%胎牛血清(中乔新舟  货号:ZQ500-A+1%P/S(中乔新舟  货号:CSP006

推荐完全培养基货号

ZM1165

生物安全等级

BSL-1

培养条件

95%空气,5%二氧化碳;37℃

STR位点信息

Amelogenin :X,Y
D3S1358: 15,16,17
TH01: 6,8
D21S11: 29,30
D18S51: 13,17,18
D5S818: 12
D13S317: 12,13
D7S820: 8,10
D16S539: 11,13,14
CSF1PO: 11,12
vWA: 17
D8S1179: 9,13,14,15
TPOX: 8
FGA: 22,24
D19S433: 14,15
D2S1338: 23,24
Penta_E: 14,16
Penta_D: 8,13

抗原表达/受体表达

*** 

基因表达

*** 

保藏机构

ATCC; CRL-1552 BCRC; 60106 CLS; 300116 DSMZ; ACC-84 ECACC; 90021901

供应限制

仅供科研使用


货号

ZQ1165

发货规格

活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一

发货形式

活细胞:常温运输;冻存管:干冰运输

储存温度

活细胞:培养箱;冻存管:液氮罐

产地

中国

供应限制

仅供科研使用

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