产品名称 |
GIST-T1 人胃肠道间质瘤细胞 |
货号 |
ZQ1178 |
产品介绍 |
一种新的人类细胞系GIST-T1是从一名47岁日本妇女胃的胃肠间质瘤(GIST)的转移性复合肿瘤中建立的,并通过免疫组织化学、常规显带方法、比较基因组杂交(CGH)和荧光原位杂交(FISH)进行表征。 |
种属 |
人 |
性别/年龄 |
女/47岁 |
组织 |
胃 |
疾病 |
胃肠间质瘤 |
细胞类型 |
肿瘤细胞 |
形态学 |
上皮 |
生长方式 |
贴壁 |
倍增时间 |
~48小时 |
培养基和添加剂 |
DMEM (中乔新舟 货号:ZQ-100)+10%胎牛血清(中乔新舟 货号:ZQ500-A)+1%P/S(中乔新舟 货号:CSP006) |
推荐完全培养基货号 |
ZM1178 |
生物安全等级 |
BSL-1 |
培养条件 |
95%空气,5%二氧化碳;37℃ |
STR位点信息 |
Amelogenin: X, |
抗原表达/受体表达 |
*** |
基因表达 |
*** |
保藏机构 |
*** |
供应限制 |
仅供科研使用 |
货号 |
ZQ1178 |
发货规格 |
活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一 |
发货形式 |
活细胞:常温运输;冻存管:干冰运输 |
储存温度 |
活细胞:培养箱;冻存管:液氮罐 |
产地 |
中国 |
供应限制 |
仅供科研使用 |
PubMed=12004007; DOI=10.1038/labinvest.3780461
Taguchi T., Sonobe H., Toyonaga S.-i., Yamasaki I., Shuin T., Takano A., Araki K., Akimaru K., Yuri K.
Conventional and molecular cytogenetic characterization of a new human cell line, GIST-T1, established from gastrointestinal stromal tumor.
Lab. Invest. 82:663-665(2002)
PubMed=16077968; DOI=10.3892/or.14.3.645
Noma K., Naomoto Y., Gunduz M., Matsuoka J., Yamatsuji T., Shirakawa Y., Nobuhisa T., Okawa T., Takaoka M., Tomono Y., Hiroyuki O., Gunduz E., Tanaka N.
Effects of imatinib vary with the types of KIT-mutation in gastrointestinal stromal tumor cell lines.
Oncol. Rep. 14:645-650(2005)
PubMed=19706776; DOI=10.1158/0008-5472.CAN-08-4004
Muhlenberg T., Zhang Y.-X., Wagner A.J., Grabellus F., Bradner J.E., Taeger G., Lang H., Taguchi T., Schuler M., Fletcher J.A., Bauer S.
Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors.
Cancer Res. 69:6941-6950(2009)
PubMed=22665524; DOI=10.1158/1535-7163.MCT-12-0223
Heinrich M.C., Marino-Enriquez A., Presnell A., Donsky R.S., Griffith D.J., McKinley A., Patterson J., Taguchi T., Liang C.-W., Fletcher J.A.
Sorafenib inhibits many kinase mutations associated with drug-resistant gastrointestinal stromal tumors.
Mol. Cancer Ther. 11:1770-1780(2012)
PubMed=23716303; DOI=10.1002/ijc.28282
Takahashi T., Serada S., Ako M., Fujimoto M., Miyazaki Y., Nakatsuka R., Ikezoe T., Yokoyama A., Taguchi T., Shimada K., Kurokawa Y., Yamasaki M., Miyata H., Nakajima K., Takiguchi S., Mori M., Doki Y., Naka T., Nishida T.
New findings of kinase switching in gastrointestinal stromal tumor under imatinib using phosphoproteomic analysis.
Int. J. Cancer 133:2737-2743(2013)
PubMed=25239608; DOI=10.1158/1078-0432.CCR-14-1397
Garner A.P., Gozgit J.M., Anjum R., Vodala S., Schrock A.B., Zhou T.-J., Serrano C., Eilers G., Zhu M.-J., Ketzer J., Wardwell S., Ning Y., Song Y., Kohlmann A., Wang F., Clackson T., Heinrich M.C., Fletcher J.A., Bauer S., Rivera V.M.
Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients.
Clin. Cancer Res. 20:5745-5755(2014)
PubMed=27997714; DOI=10.1002/gcc.22438
Takahashi T., Elzawahry A., Mimaki S., Furukawa E., Nakatsuka R., Nakamura H., Nishigaki T., Serada S., Naka T., Hirota S., Shibata T., Tsuchihara K., Nishida T., Kato M.
Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors.
Genes Chromosomes Cancer 56:303-313(2017)
PubMed=29866822; DOI=10.1073/pnas.1802079115
Hemming M.L., Lawlor M.A., Zeid R., Lesluyes T., Fletcher J.A., Raut C.P., Sicinska E.T., Chibon F., Armstrong S.A., Demetri G.D., Bradner J.E.
Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome.
Proc. Natl. Acad. Sci. U.S.A. 115:E5746-E5755(2018)
PubMed=32736695; DOI=10.1016/j.bbrc.2020.05.174
Cho W.-C., Shin Y.-K., Na Y.-S., Ryu M.-H., Ku J.-L., Kang Y.-K.
The role of novel fusion genes in human GIST cell lines derived from imatinib-resistant GIST patients: a therapeutic potential of fusion gene.
Biochem. Biophys. Res. Commun. 529:699-706(2020)
PubMed=34738628; DOI=10.3892/or.2021.8218
Shima T., Taniguchi K., Tokumaru Y., Inomata Y., Arima J., Lee S.-W., Takabe K., Yoshida K., Uchiyama K.
Glucose transporter-1 inhibition overcomes imatinib resistance in gastrointestinal stromal tumor cells.
Oncol. Rep. 47:7.1-7.13(2022)