人脑血管平滑肌细胞描述：
血管平滑肌细胞是许多动脉疾病在细胞水平上的根源。血管平滑肌细胞的加速生长能力是血管疾病进展的关键因素。最新研究表明，血管平滑肌细胞表达ICAM-1 和 VCAM-1能促进血管壁的炎症反应，并且与血管疾病的发展及稳定性有关。人血管平滑肌细胞的体外培养是血管研究中的重要模型，并将对血管疾病的药理学和治疗研究提供大量信息。
人脑血管平滑肌细胞 (HBVSMC)提取于人脑血管组织，原代冻存。每管含有细胞数 >5×105 cells/ml，此细胞通过对alpha-smooth muscle actin 和desmin免疫荧光染色验证，经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。细胞可以达到15倍增。
推荐培养基：平滑肌细胞培养基（SMCM, Cat. No. 1101)
产品使用说明:本产品仅用于科研。
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货号
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1100
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产地
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美国
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缩写
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HBVSMC
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规格
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5 x 10^5 cells/vial
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用途
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科研
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运输
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干冰
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保存
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液氮
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1.) Reynolds, M.R., Singh, I., Azad, T.D., Holmes, B.B., Verghese, P.B., Dietrich, H.H., Diamond, M., Bu, G., Han, B.H. & Zipfel, G.J. (2016) Heparan sulfate proteoglycans mediate A?-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells Mol Neurodegener. 11
2.) Kikkawa Y, Matsuo S, Kurogi R, Nakamizo A, Mizoguchi M, Sasaki T. (2014) 'Upregulation of Relaxin after Experimental Subarachnoid Hemorrhage in Rabbits.'
3.) Shi X, Fu Y, Liao D, Chen Y, Liu J. (2014) 'Alterations of Voltage-Dependent Calcium Channel Currents in Basilar Artery Smooth Muscle Cells at Early Stage of Subarachnoid Hemorrhage in a Rabbit Model.'
4.) Kikkawa Y, Matsuo S, Kurogi R, Nakamizo A, Mizoguchi M, Sasaki T. (2014) "Upregulation of Relaxin after Experimental Subarachnoid Hemorrhage in Rabbits." Biomed res int. 2014: 836397.
5.) Shi X, Fu Y, Liao D, Chen Y, Liu J. (2014) "Alterations of Voltage-Dependent Calcium Channel Currents in Basilar Artery Smooth Muscle Cells at Early Stage of Subarachnoid Hemorrhage in a Rabbit Model." PloS one. 9: e84129.
6.) Cucullo L, Hossain M, Tierney M, Janigro D. (2013) "A new dynamic in vitro modular capillaries-venules modular system: cerebrovascular physiology in a box." BMC Neurosci. 14: 18.
7.) Meng H, Zhang X, Lee SJ, Wang MM. (2013) "Von Willebrand Factor Inhibits Mature Smooth Muscle Gene Expression through Impairment of Notch Signaling." PLoS One. 8: e75808.
8.) Miners JS, Kehoe P, Love S. (2011). "Neprilysin protects against cerebral amyloid angiopathy and Abeta-induced degeneration of cerebrovascular smooth muscle cells."Brain Patholology. 21: 594-605
9.) Fossati S, Cam J, Meyerson J, Mezhericher E, Romero IA, Couraud PO, Weksler BB, Ghiso J, Rostagno A. (2010) "Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-beta variants in cells composing the cerebral vessel walls." FASEB J. 24: 229-41.
10.) Lefterov I, Fitz NF, Cronican AA, Fogg A, Lefterov P, Kodali R, Wetzel R, Koldamova R. (2010) "Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice." J Biol Chem 285: 36945-57.
11.) Kanekiyo T, Bu G. (2009) "Receptor-associated protein interacts with amyloid-beta peptide and promotes its cellular uptake." J Biol Chem. 284: 33352-59.
12.) Wang J, Tuo H, Wang R, Li W, Feng Z, Chen J, Wang D. (2008) "The expression of human brain vascular smooth muscle cell AT receptor after the UL83 gene of HCMV inhibition by small interfering RNAs." Neurol Res. 30: 903-09.
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