产品名称	BT-549人乳腺管癌细胞
货号	ZQ0376
产品介绍	BT-549细胞是一种人类乳腺癌细胞系，来源于一名56岁患有导管癌的白人女性的乳腺组织。它通常用于癌症研究，研究乳腺癌的生物学和治疗，特别是三阴性亚型，缺乏雌激素受体、孕激素受体和HER2表达。 BT-549细胞以其上皮形态为特征，以其高侵袭性而闻名，使其成为研究转移和肿瘤侵袭的重要模型。它表现出几个独特的特征，包括在细胞质中存在脂滴和粘蛋白-1蛋白的强烈表达。这细胞还表达各种与乳腺癌病理相关的癌基因和抑癌基因，如TP53和RB1。 BT-549细胞系雌激素受体阴性，孕激素受体阴性，且不扩增HER2，因此属于三阴性乳腺癌(TNBC)亚型。由于这种分类，BT-549细胞对于研究TNBC中独特的进展和治疗反应机制特别有用，TNBC以其侵袭性和缺乏靶向治疗而闻名。 此外，BT-549细胞经常用于耐药研究和测试新的化疗药物和靶向治疗，为管理和治疗侵袭性乳腺癌的潜在治疗策略提供见解。 注意事项： (1)BT-549细胞传代后24-48小时后细胞大部分可贴壁，，建议传代后细胞48小时换液。细胞呈上皮样多边形和少量圆细胞. (2)复苏冻存细胞24小时后会有大量细胞漂浮，48小时后换液，此后每两天换液一次，7-10天后可达到传代密度，细胞需要高密度冻存。
种属	人
性别/年龄	女/72岁
组织	乳腺；胸肉
疾病	导管癌
细胞类型	肿瘤细胞
形态学	上皮
生长方式	贴壁
倍增时间	大约25.46~53.9小时
培养基和添加剂	RPMI-1640（中乔新舟 货号：ZQ-200）+10%胎牛血清（中乔新舟 货号：ZQ0500）+1%P/S（中乔新舟  货号：CSP006）++0.023IU/ml胰岛素（中乔新舟  货号：CSP001-10）
推荐完全培养基货号	ZM0376
生物安全等级	BSL-1
STR位点信息	Amelogenin : X CSF1PO: 10 , 12 D13S317: 11 D16S539 : 8 D5S818: 11 D7S820: 9, 10 TPOX: 8 TH01: 9.3 vWA : 15
培养条件	95%空气，5%二氧化碳；37℃
抗原表达/受体表达	***
基因表达	***
保藏机构	ATCC; HTB-122
供应限制	仅供科研使用

货号	ZQ0376
发货规格	活细胞：T25培养瓶*1瓶或者1ml 冻存管*1支（细胞量约为5 x 10^5 cells/vial）二选一
发货形式	活细胞：常温运输；冻存管：干冰运输
储存温度	活细胞：培养箱；冻存管：液氮罐
产地	中国
供应限制	仅供科研使用

论文标题： Cardamonin inhibits breast cancer growth by repressing HIF-1α-dependent metabolic reprogramming
DOI： 10.1186/s13046-019-1351-4
发表时间： 2019-08-27
期刊： JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
影响因子： 5.646
货号： ZQ0376
产品名称： BT549 cells

原文链接： https://jeccr.biomedcentral.com/articles/10.1186/s13046-019-1351-4

论文标题： Development of a Prognostic Model Based on the Identification of EMT-Related lncRNAs in Triple-Negative Breast Cancer
DOI： 10.1155/2021/9219961
发表时间： 2021-11-27
期刊： Journal of Oncology
影响因子： 4.375
货号： ZQ0376
产品名称： BT-549 cell
原文链接： https://www.hindawi.com/journals/jo/2021/9219961/

论文标题： Verteporfin inhibits cell proliferation and induces apoptosis in different subtypes of breast cancer cell lines without light activation
DOI： 10.1186/s12885-020-07555-0
发表时间： 2020-10-29
期刊： BMC CANCER
影响因子： 3.15
货号： ZQ0376
产品名称： BT-549 cells
原文链接： https://bmccancer.biomedcentral.com/articles/10.1186/s12885-020-07555-0

论文标题： P16 promotes the growth and mobility potential of breast cancer both in vitro and in vivo: the key role of the activation of IL-6/JAK2/STAT3 signaling
DOI： 10.1007/s11010-018-3281-4
发表时间： 2018-01-31
期刊： MOLECULAR AND CELLULAR BIOCHEMISTRY
影响因子： 2.561
货号： ZQ0376
产品名称： BT-549 cells
原文链接： https://link.springer.com/article/10.1007/s11010-018-3281-4

论文标题： Determination of the migration effect and molecular docking of verteporfin in different subtypes of breast cancer cells
DOI： 10.3892/mmr.2020.11482
发表时间： 2020-09-02
期刊： Molecular Medicine Reports
影响因子： 2.1
货号： ZQ0376
产品名称： BT-549 cells

原文链接： https://www.spandidos-publications.com/10.3892/mmr.2020.11482

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