产品名称	NCI-H358人非小细胞肺癌细胞
货号	ZQ0384
产品介绍	NCI-H358，也被称为H-358或NCIH358，是一种上皮样细胞系，来源于一名非小细胞肺癌(NSCLC)亚型细支气管肺泡癌患者。超微结构研究表明细胞质中有Clara细胞的特征结构 细胞表达主要的肺表面结合蛋白SP-A的蛋白和RNA。 不表达SP-B和SP-C。 他们在软琼脂中的克隆形成效率为0.83%。NCI-H358细胞在以非小细胞肺癌为重点的癌症研究中尤其重要，特别是在探索肺腺癌的生物学和治疗方面。 该细胞系对于研究靶向表皮生长因子受体(EGFR)治疗的有效性至关重要，因为EGFR突变是治疗非小细胞肺癌的一个重要焦点。此外，NCI-H358细胞对于研究KRAS突变的作用很有价值，KRAS突变在肺癌中很普遍，并且已知会驱动致癌活性。NCI-H358细胞中这些突变的研究有助于阐明参与肺癌进展和治疗耐药的分子途径。 NCI-H358细胞系含有p53的纯合缺失，p53是一种主要的肿瘤抑制因子。H358肺癌细胞系也被用于评估新的治疗方法的潜力，例如针对特定致癌途径的SOS1 PROTACs。 总之，来自细支气管肺泡癌的NCI-H358细胞系是研究非小细胞肺癌的重要工具。这对于研究egfr靶向治疗和KRAS突变在肺癌中的作用具有重要意义。它在癌症研究中的应用扩展到旨在减轻致癌突变影响和改善肺癌患者预后的新治疗策略的开发。
种属	人
性别/年龄	男
组织	肺/支气管；来源于转移部位:肺泡
疾病	细支气管肺泡癌；非小细胞肺癌
细胞类型	肿瘤细胞
形态学	上皮细胞
生长方式	贴壁
倍增时间	大约38~76小时
培养基和添加剂	RPMI-1640（品牌：中乔新舟 货号：ZQ-200）+10%FBS（品牌：中乔新舟 货号:ZQ500-A）+1%P/S（中乔新舟  货号：CSP006）
推荐完全培养基货号	ZM0384
生物安全等级	BSL-1
STR位点信息	Amelogenin: X,Y CSF1PO: 11,12 D13S317: 8,12 D16S539: 12,13 D5S818: 10,12 D7S820: 10,11 TH01: 6 TPOX: 8,9 vWA: 17
培养条件	95%空气，5%二氧化碳；37℃
抗原表达/受体表达	***
基因表达	***
保藏机构	ATCC; CRL-5807 ECACC; 95111733
供应限制	仅供科研使用

货号	ZQ0384
发货规格	活细胞：T25培养瓶*1瓶或者1ml 冻存管*1支（细胞量约为5 x 10^5 cells/vial）二选一
发货形式	活细胞：常温运输；冻存管：干冰运输
储存温度	活细胞：培养箱；冻存管：液氮罐
产地	中国
供应限制	仅供科研使用

论文标题： NEDD4L-induced ubiquitination mediating UBE2T degradation inhibits progression of lung adenocarcinoma via PI3K-AKT signaling
DOI： 10.1186/s12935-021-02341-9
发表时间： 2021-11-27
期刊： Cancer Cell International
影响因子： 5.722
货号： ZQ0384
产品名称： H358 cells

原文链接： https://cancerci.biomedcentral.com/articles/10.1186/s12935-021-02341-9

论文标题： LncRNA PCBP1-AS1 correlated with the functional states of cancer cells and inhibited lung adenocarcinoma metastasis by suppressing the EMT progression
DOI： 10.1093/carcin/bgab047
发表时间： 2021-07-16
期刊： CARCINOGENESIS
影响因子： 4.944
货号： ZQ0384
产品名称： H358 cells
原文链接： https://academic.oup.com/carcin/advance-article-abstract/doi/10.1093/carcin/bgab047/6295508

 论文标题： High expression of 14‑3‑3ơ indicates poor prognosis and progression of lung adenocarcinoma
DOI： 10.3892/ol.2022.13323
发表时间： 2022-05-12
期刊： Oncology Letters
影响因子： 2.967
货号： ZQ0384
产品名称： NCI-H358 cells
原文链接： https://www.spandidos-publications.com/10.3892/ol.2022.13323

论文标题： Loading MicroRNA-376c in Extracellular Vesicles Inhibits Properties of Non-Small Cell Lung Cancer Cells by Targeting YTHDF1:
DOI： 10.1177/1533033820977525
发表时间： 2020-12-07
期刊： TECHNOLOGY IN CANCER RESEARCH & TREATMENT
影响因子： 2.074
货号： ZQ0384
产品名称： NCI-H358 cells

原文链接： https://journals.sagepub.com/doi/abs/10.1177/1533033820977525

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