产品名称	Calu-3人肺腺癌 (胸水)
货号	ZQ0392
产品介绍	Calu-3细胞是一种人类上皮细胞系，来源于1975年25岁患者的肺腺癌，该患者先前接受了环磷酰胺、博莱霉素和阿霉素的治疗。该细胞表现出上皮形态，其特点是能够形成紧密连接、桥粒和微绒毛，反映了肺上皮的结构特征。Calu 3细胞以其高水平分泌粘蛋白而闻名，粘蛋白是一种参与保护和润滑肺气道的糖蛋白，使其成为研究气道上皮生物学(包括粘蛋白的产生、分泌及其调控)的相关体外模型。 Calu-3人肺腺癌细胞被用于药物的发现和开发，特别是用于评估吸入药物的吸收、分布、代谢和排泄(ADME)。它们在可渗透支架上培养时形成极化单层的能力使它们适合于研究药物转运和药物对气道上皮的影响。 Calu 3细胞来源于人类肺癌细胞类型，在气道上皮细胞及其在呼吸系统疾病中的作用的研究中尤为重要。这些细胞来源于支气管粘膜下腺，并被用于细胞培养模型来模拟人类气道，为呼吸功能、上皮细胞损伤、肺损伤和囊性纤维化或SARS等疾病的研究提供见解。 该细胞及其对化疗药物反应的研究有助于拓宽肺癌研究领域，为治疗效果和开发更有效的治疗策略提供见解。 注意事项： （1）Calu-3细胞难消化，胰酶消化细胞应该以细胞变圆脱落冲散即可。 （2）该细胞形态不均一，有一些含有液泡的巨大细胞。细胞胞体有黑色颗粒物，属正常现象。
种属	人
性别/年龄	男/25岁
组织	肺腺癌；来源于转移部位:胸腔积液
疾病	腺癌
细胞类型	肿瘤细胞
形态学	上皮的
生长方式	贴壁
倍增时间	大约35~84小时
培养基和添加剂	MEM（含NEAA）（品牌：中乔新舟  货号：ZQ-300）+10%胎牛血清（中乔新舟 货号：ZQ0500）+1%P/S（中乔新舟  货号：CSP006）
推荐完全培养基货号	ZM0392
生物安全等级	BSL-1
STR位点信息	Amelogenin: X CSF1PO: 11,12 D13S317: 12 D16S539: 12,14 D5S818: 11 D7S820: 10,11 TH01: 6,9.3 TPOX: 8 vWA: 16,17
培养条件	95%空气，5%二氧化碳；37℃
抗原表达/受体表达	***
基因表达	***
保藏机构	ATCC; HTB-55 BCRJ; 0264
供应限制	仅供科研使用

货号	ZQ0392
发货规格	活细胞：T25培养瓶*1瓶或者1ml 冻存管*1支（细胞量约为5 x 10^5 cells/vial）二选一
发货形式	活细胞：常温运输；冻存管：干冰运输
储存温度	活细胞：培养箱；冻存管：液氮罐
产地	中国
供应限制	仅供科研使用

论文标题： Active components in Ephedra sinica stapf disrupt the interaction between ACE2 and SARS-CoV-2 RBD: Potent COVID-19 therapeutic agents
DOI： 10.1016/j.jep.2021.114303
发表时间： 2021-06-05
期刊： JOURNAL OF ETHNOPHARMACOLOGY
影响因子： 4.36
货号： ZQ0392
产品名称： Human airway epithelial cells (Calu-3)

原文链接： https://www.sciencedirect.com/science/article/pii/S0378874121005304

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