产品名称	MKN-45人胃癌细胞
货号	ZQ0457
产品介绍	MKN-45细胞系是一种人胃癌细胞系，来源于日本一位62岁患者低分化的胃腺癌。细胞表现出胃癌的典型特征，包括快速生长和高度的遗传不稳定性。MKN-45细胞常用于癌症研究，研究肿瘤生物学、耐药机制和胃癌进展的分子途径。当异种移植到免疫功能低下的小鼠体内时，它们形成肿瘤的能力使它们成为体内研究的有价值的模型。 MKN-45细胞本质上是上皮细胞，在培养中以贴壁细胞的形式生长。它表达各种与胃癌相关的生物标志物，如癌胚抗原(CEA)和e -钙粘蛋白，使它在诊断和治疗研究中有用。此外，由于MKN-45细胞对治疗的反应性和模仿人类胃肿瘤临床行为的能力，经常被用于化疗药物和靶向治疗的评估。研究人员还利用这种细胞系来探索基因修饰的影响，并开发新的治疗策略，旨在改善胃癌患者的预后。
种属	人
性别/年龄	女/62岁
组织	胃
疾病	腺癌
细胞类型	肿瘤细胞
形态学	圆形
生长方式	贴壁
倍增时间	大约16~60小时
培养基和添加剂	RPMI-1640（品牌：中乔新舟  货号：ZQ-200）+20%胎牛血清（中乔新舟 货号：ZQ0500）+1%P/S（中乔新舟  货号：CSP006）
推荐完全培养基货号	ZM0457
生物安全等级	BSL-1
STR位点信息	Amelogenin：X CSF1PO：12 D13S317：8，11 D16S539：10 D18S51：16 D19S433：14，16.2 D21S11：31 D2S1338：OL D3S1358：15，16 D5S818：10，11 D7S820：10，11 D8S1179：13，17 FGA：19，24 TH01：7 TPOX：8 vWA：19
培养条件	95%空气，5%二氧化碳；37℃
抗原表达/受体表达	***
基因表达	***
保藏机构	DSMZ; ACC-409；JCRB; JCRB0254
供应限制	仅供科研使用

货号	ZQ0457
发货规格	活细胞：T25培养瓶*1瓶或者1ml 冻存管*1支（细胞量约为5 x 10^5 cells/vial）二选一
发货形式	活细胞：常温运输；冻存管：干冰运输
储存温度	活细胞：培养箱；冻存管：液氮罐
产地	中国
供应限制	仅供科研使用

论文标题： LRG1 mediated by ATF3 promotes growth and angiogenesis of gastric cancer by regulating the SRC/STAT3/VEGFA pathway
DOI： 10.1007/s10120-022-01279-9
发表时间： 2022-01-30
期刊： Gastric Cancer
影响因子： 7.37
货号： ZQ0457
产品名称： MKN45 cells

原文链接： https://link.springer.com/article/10.1007/s10120-022-01279-9

论文标题： Up-regulation of DGAT1 in cancer tissues and tumor-infiltrating macrophages influenced survival of patients with gastric cancer
DOI： 10.1186/s12885-021-07976-5
发表时间： 2021-03-09
期刊： BMC CANCER
影响因子： 4.43
货号： ZQ0457
产品名称： MKN45 cells
原文链接： https://bmccancer.biomedcentral.com/articles/10.1186/s12885-021-07976-5

论文标题： LINC_00355 promotes gastric cancer progression by upregulating PHF19 expression through sponging miR-15a-5p
DOI： 10.1186/s12885-021-08227-3
发表时间： 2021-06-02
期刊： BMC CANCER
影响因子： 4.43
货号： ZQ0457
产品名称： MKN45 cells
原文链接： https://bmccancer.biomedcentral.com/articles/10.1186/s12885-021-08227-3

论文标题： Knockdown of lncRNA SNHG4 suppresses gastric cancer cell proliferation and metastasis by targeting miR-204-5p.
DOI： 10.4149/neo_2021_200914n981
发表时间： 2021-02-11
期刊： NEOPLASMA
影响因子： 2.575
货号： ZQ0457
产品名称： "human gastric
cancer cell lines MKN-45"

原文链接： https://europepmc.org/article/med/33567852?javascript_support=no

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