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人肺泡上皮细胞

英文名:Human Pulmonary Alveolar Epithelial Cells
货号:3200
价格:¥15030.00
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人肺泡上皮细胞说明:

      

       人肺泡上皮细胞由肺泡I型和Ⅱ型上皮细胞组成,线性分布于肺内99%以上的表面积。肺泡I型细胞是一种大而扁平细胞,其稀薄的细胞质延展占据了其内表面积的95%以上。它含有水通道,是所有哺乳动物细胞中水渗透性最高的细胞。肺泡Ⅱ型上皮细胞只占据了2-5%的面积,它能产生,分泌并再利用肺表面活性物质。肺泡Ⅱ型上皮细胞同时含有Na+-K+-ATP酶和阿米洛利敏感的上皮细胞Na+通道。目前被普遍接受的假说是肺泡Ⅱ型上皮细胞通过调节肺Na+传递的活性来维持着肺液体内环境稳定平衡,而肺泡I型细胞是无活性的细胞,仅提供屏障功能而无活化功能。新近的研究表明肺泡I型在调节离子和液体转运过程中也具有重要作用。   


       人肺泡上皮细胞(HPAEpiC)提取于人肺组织,原代冻存。每管含有细胞数>1×106cells/ml,此细胞通过Cytokeratin-18, -19和Vimentin免疫荧光染色验证,经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。


推荐培养基: 肺泡上皮细胞培养基(AEpiCM, Cat. No. 3201)


产品使用说明:仅供科研研究使用,禁止用于人或动物的体外诊断。

货号 3200
产地 美国
缩写 HPAEpiC
规格 1 x 10^6 cells/vial
用途 科研
运输 干冰
保存 液氮
1.) Akimoto, M., Hayashi, J.I., Nakae, S., Saito, H. & Takenaga, K. (2016) Interleukin-33 enhances programmed oncosis of ST2L-positive low-metastatic cells in the tumour microenvironment of lung cancer Cell Death Dis. 7

2.) Ilia Atanelishvili , Yuichiro Shirai , Tanjina Akter, Atsushi Noguchi, Kurt T. Ash, Suniti Misra, Sibnath Ghatak, Richard M. Silver, Galina S. Bogatkevich (2016) "D1398G Variant of MET Is Associated with Impaired Signaling of Hepatocyte Growth Factor in Alveolar Epithelial Cells and Lung Fibroblasts" PLoS ONE 11(9): e0162357. 

3.) Cao J, Wang D, Xu F, Gong Y, Wang H, Song Z, Li D, Zhang H, Li D, Zhang L, Xia Y, Xu H, Lai X, Lin S, Zhang X, Ren G, Dai Y, Yin Y. (2014) 'Activation of IL?27 signalling promotes development of postinfluenza pneumococcal pneumonia.'

4.) Cao J, Wang D, Xu F, Gong Y, Wang H, Song Z, Li D, Zhang H, Li D, Zhang L, Xia Y, Xu H, Lai X, Lin S, Zhang X, Ren G, Dai Y, Yin Y. (2014) "Activation of IL?27 signalling promotes development of postinfluenza pneumococcal pneumonia." EMBO mol med. 6: 120-140.

5.) Lee IT, Lin CC, Cheng SE, Hsiao LD, Hsiao YC, Yang CM. (2013) "TNF-α Induces Cytosolic Phospholipase A2 Expression in Human Lung Epithelial Cells via JNK1/2- and p38 MAPK-Dependent AP-1 Activation." 8: e72783. 

6.) Eckle T, Brodsky K, Bonney M, Packard T, Han J, Borchers CH, Mariani TJ, Kominsky DJ, Mittelbronn M, Eltzschig HK. (2013) "HIF1A Reduces Acute Lung Injury by Optimizing Carbohydrate Metabolism in the Alveolar Epithelium." PLoS Biol. 11: e1001665.

7.) Shilo K, Wu X, Sharma S, Welliver M, Duan W, Villalona-Calero M, Fukuoka J, Sif S, Baiocchi R, Hitchcock CL, Zhao W, Otterson GA. (2013) 'Cellular localization of protein arginine methyltransferase-5 correlates with grade of lung tumors.'

8.) Chang RS, Wang YC, Kao ST. (2013) 'Soluble toll-like receptor 4 reversed attenuating effect of Chinese herbal Xiao-Qing-Long-Tang on allergen induced nerve growth factor and thymic stromal lymphopoietin.'

9.) Chang RS, Wang YC, Kao ST. (2013) "Soluble toll-like receptor 4 reversed attenuating effect of Chinese herbal Xiao-Qing-Long-Tang on allergen induced nerve growth factor and thymic stromal lymphopoietin." Expther med. 6: 1199-1207.

10.) Shilo K, Wu X, Sharma S, Welliver M, Duan W, Villalona-Calero M, Fukuoka J, Sif S, Baiocchi R, Hitchcock CL, Zhao W, Otterson GA. (2013) "Cellular localization of protein arginine methyltransferase-5 correlates with grade of lung tumors." Diagnpathol.8: 201.

11.) Kuo YB, Chang CA, Wu YK, Hsieh MJ, Tsai CH, Chen KT, Chen CY, Chan EC. (2010) "Identification and clinical association of anti-cytokeratin 18 autoantibody in COPD."Immunol Lett. 128: 131-6.

12.) Lin CC, Kuo CT, Cheng CY, Wu CY, Lee CW, Hsieh HL, Lee IT, Yang CM. (2009) "IL-1 beta promotes A549 cell migration via MAPKs/AP-1- and NF-kappaB-dependent matrix metalloproteinase-9 expression." Cell Signal. 21: 1652-62. 

13.) Malizia AP, Egan JJ, Doran PP. (2009) "IL-4 increases CD21-dependent infection of pulmonary alveolar epithelial type II cells by EBV." Mol Immunol. 46: 1905-10.

14.) Lin CC, Tseng HW, Hsieh HL, Lee CW, Wu CY, Cheng CY, Yang CM. (2008) "Tumor necrosis factor-alpha induces MMP-9 expression via p42/p44 MAPK, JNK, and nuclear factor-kappaB in A549 cells." Toxicol Appl Pharmacol. 229: 386-98. 

15.) Gentry M, Taormina J, Pyles RB, Yeager L, Kirtley M, Popov VL, Klimpel G, Eaves-Pyles T. (2007) "Role of primary human alveolar epithelial cells in host defense against Francisella tularensis infection." Infect Immun. 75: 3969-78.

16.) Sims AC, Baric RS, Yount B, Burkett SE, Collins PL, Pickles RJ. (2005) "Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: role of ciliated cells in viral spread in the conducting airways of the lungs." J Virol. 79: 15511-24.

17.) Tsuji T, Aoshiba K, Nagai A. (2004) "Cigarette Smoke Induces Senescence in Alveolar Epithelial Cells American." Am J Respir Cell Mol Biol. 31: 643-9.


18.)An oncolytic herpes virus expressing E-cadherin resists NK cell clearance and improves viral spread and glioblastoma virotherapy,Nat Biotechnol. 2018 Nov 26 : 10.1038/nbt.4302.Published online 2018 Nov 26. doi: 10.1038/nbt.4302


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