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使用细胞产品已发表的部分文献(截止到2013年)


Sciencell的产品已经在800多篇研究性论文中被标注。 


部分产品展示(详细查询请见http://sciencellonline.com/technical-support/publications.html):


例如一:人脑微血管内皮细胞(Human Brain Microvascular Endothelial Cells)

1.) Lim PJ, Chu JJH. (2014) 'A Polarized Cell Model for Chikungunya Virus Infection: Entry and Egress of Virus Occurs at the Apical Domain of Polarized Cells.'

2.) Lim PJ, Chu JJH. (2014) "A Polarized Cell Model for Chikungunya Virus Infection: Entry and Egress of Virus Occurs at the Apical Domain of Polarized Cells." PLoSnegl trop dis. 8: e2661.

3.) Pilakka-Kanthikeel S, Atluri VSR, Sagar V, Saxena SK, Nair M. (2013) "Targeted brain derived neurotropic factors (BDNF) delivery across the blood-brain barrier for neuro-protection using magnetic nano carriers: an in-vitro study." PLoS One. 8: e62241.

4.) Cucullo L, Hossain M, Tierney W, Janigro D. (2013) "A new dynamic in vitro modular capillaries-venules modular system: Cerebrovascular physiology in a box." BMC Neuroscience. 14:18

5.) Seo HS, Minasov G, Seepersaud R, Doran KS, Dubrovska I, Shuvalova L, Wayne AF, Tina IM, Sullam PM. (2013) 'Characterization of fibrinogen binding by glycoproteins Srr1 and Srr2 of Streptococcus agalactiae.'

6.) Muniz-Feliciano L, Van GJ, Portillo JAC, Liew L, Liu B, Carlin CR, Carruthers VB, Matthews S, Subauste CS. (2013) 'Toxoplasma gondii-Induced Activation of EGFR Prevents Autophagy Protein-Mediated Killing of the Parasite.'

7.) Muniz-Feliciano L, Van GJ, Portillo JAC, Liew L, Liu B, Carlin CR, Carruthers VB, Matthews S, Subauste CS. (2013) "Toxoplasma gondii-Induced Activation of EGFR Prevents Autophagy Protein-Mediated Killing of the Parasite." PLoSPathog. 9: e1003809.

8.) Seo HS, Minasov G, Seepersaud R, Doran KS, Dubrovska I, Shuvalova L, Wayne AF, Tina IM, Sullam PM. (2013) "Characterization of fibrinogen binding by glycoproteins Srr1 and Srr2 of Streptococcus agalactiae." J Biol Chem. 288: 35982-96.

9.) Claessens A, Adams Y, Ghumra A, Lindergard G, Buchan CC, Andisi C, Bull PC, Mok S, Gupta AP, Wang CW, Turner L, Arman M, Raza A, Bozdech Z, Rowe JA. (2012) "A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells." Proc Natl Acad Sci USA. 109: E1772-81. 

10.) Yan J, Zhang Z, Shi H. (2012) "HIF-1 is involved in high glucose-induced paracellular permeability of brain endothelial cells." Cell Mol Life Sci. 69: 115-28.

11.) Cucullo L, Hossain M, Puvenna V, Marchi N, Janigro D. (2011) "The role of shear stress in Blood-Brain Barrier endothelial physiology." BMC Neurosci. 12: 40.

12.) Feng S, Cen J, Huang Y, Shen H, Yao L, Wang Y, Chen Z. (2011) "Matrix metalloproteinase-2 and -9 secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight junction proteins." PLoS One. 6: e20599.

13.) Grau S, Thorsteinsdottir J, von Baumgarten L, Winkler F, Tonn JC, Schichor C. (2011) "Bevacizumab can induce reactivity to VEGF-C and -D in human brain and tumour derived endothelial cells." J Neurooncol. 104: 103-12. 

14.) Kuo YC, Lu CH. (2011) "Effect of human astrocytes on the characteristics of human brain-microvascular endothelial cells in the blood-brain barrier." Colloids Surf B Biointerfaces. 86: 225-31

15.) G?bel K, Pankratz S, Schneider-Hohendorf T, Bittner S, Schuhmann MK, Langer HF, Stoll G, Wiendl H, Kleinschnitz C, Meuth SG. (2011) "Blockade of the kinin receptor B1 protects from autoimmune CNS disease by reducing leukocyte trafficking." J Autoimmun 36(2): 106-114. 

16.) Gandhi N, Saiyed ZM, Napuri J, Samikkannu T, Reddy PV, Agudelo M, Khatavkar P, Saxena SK, Nair MP. (2010) "Interactive role of human immunodeficiency virus type 1 (HIV-1) clade-specific Tat protein and cocaine in blood-brain barrier dysfunction: implications for HIV-1-associated neurocognitive disorder." J Neurovirol. 16: 294-305.

17.) Lin CJ, Tai Y, Huang MT, Tsai YF, Hsu HJ, Tzen KY, Liou HH. (2010) "Cellular localization of the organic cation transporters, OCT1 and OCT2, in brain microvessel endothelial cells and its implication for MPTP transport across the blood-brain barrier and MPTP-induced dopaminergic toxicity in rodents." J Neurochem. 114: 717-27.

18.) Nylund R, Kuster N, Leszczynski D. (2010) "Analysis of proteome response to the mobile phone radiation in two types of human primary endothelial cells." Proteome Sci. 8: 52.

19.) Patel NS, Mathura VS, Bachmeier C, Beaulieu-Abdelahad D, Laporte V, Weeks O, Mullan M, Paris D. (2010) "Alzheimer's beta-amyloid peptide blocks vascular endothelial growth factor mediated signaling via direct interaction with VEGFR-2." J Neurochem. 112: 66-76.

20.) Bachmeier C, Mullan M, Paris D. (2010) "Characterization and use of human brain microvascular endothelial cells to examine beta-amyloid exchange in the blood-brain barrier." Cytotechnology. 62: 519-29.

21.) Bhattacharya R, Xu Y, Rahman MA, Couraud PO, Romero IA, Weksler BB, Weidanz JA, Bickel U. (2010) "A novel vascular targeting strategy for brain-derived endothelial cells using a TCR mimic antibody." J Cell Physiol. 225: 664-72.

22.) Ghosh C, Gonzalez-Martinez J, Hossain M, Cucullo L, Fazio V, Janigro D, Marchi N. (2010) "Pattern of P450 expression at the human blood-brain barrier: roles of epileptic condition and laminar flow." Epilepsia. 51: 1408-417. 

23.) Rosch JW, Boyd AR, Hinojosa E, Pestina T, Hu Y, Persons DA, Orihuela CJ, Tuomanen EI. (2010) "Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease." J Clin Invest. 120: 627-35. 

24.) Ko YC, Chien HF, Jiang-Shieh YF, Chang CY, Pai MH, Huang JP, Chen HM, Wu CH. (2009) "Endothelial CD200 is heterogeneously distributed, regulated and involved in immune cell-endothelium interactions." J Anat. 214: 183-95. 

25.) Orihuela CJ, Mahdavi J, Thornton J, Mann B, Wooldridge KG, Abouseada N, Oldfield NJ, Self T, Ala'Aldeen DA, Tuomanen EI. (2009) "Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models." J Clin Invest. 119: 1638-46.

26.) Solito R, Corti F, Fossati S, Mezhericher E, Donnini S, Ghiso J, Giachetti A, Rostagno A, Ziche M. (2009) "Dutch and Arctic mutant peptides of beta amyloid(1-40) differentially affect the FGF-2 pathway in brain endothelium." Exp Cell Res. 315: 385-95.

27.) Zhou H, Liu X, Liu L, Yang Z, Zhang S, Tang M, Tang Y, Dong Q, Hu R. (2009) "Oxidative stress and apoptosis of human brain microvascular endothelial cells induced by free fatty acids." J Int Med Res. 37: 1897-1903. 

28.) Bousquet L, Roucairol C, Hembury A, Nevers MC, Creminon C, Farinotti R, Mabondzo A. (2008) "Comparison of ABC transporter modulation by atazanavir in lymphocytes and human brain endothelial cells: ABC transporters are involved in the atazanavir-limited passage across an in vitro human model of the blood-brain barrier." AIDS Res Hum Retroviruses. 24: 1147-54.

29.) Cucullo L, Couraud PO, Weksler B, Romero IA, Hossain M, Rapp E, Janigro D. (2008) "Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies." J Cereb Blood Flow Metab. 28: 312-28.

30.) Cucullo L, Hossain M, Rapp E, Manders T, Marchi N, Janigro D. (2007) "Development of a Humanized In Vitro Blood-Brain Barrier Model to Screen for Brain Penetration of Antiepileptic Drugs." Epilepsia. 48: 505-16.

31.) Simard JM, Tsymbalyuk O, Ivanov A, Ivanova S, Bhatta S, Geng Z, Woo SK, Gerzanich V. (2007) "Endothelial sulfonylurea receptor 1-regulated NCCa-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury." Journal of Clinical Investigation. 117: 2105-13. 

32.) Sun L, Hui AM, Su Q, Vortmeyer A, Kotliarov Y, Pastorino S, Passaniti A, Menon J, Walling J, Bailey R, Rosenblum M, Mikkelsen T, Fine HA. (2006) "Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain Cancer." Cell. 9: 287-300. 

33.) Paris D, Ait-Ghezala G, Mathura VS, Patel N, Quadros A, Laporte V, Mullan M. (2005) "Anti-angiogenic activity of the mutant Dutch A(beta) peptide on human brain microvascular endothelial cells." Brain Res Mol Brain Res. 136: 212-30.

34.) D?m?t?r E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV. (2003) "Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1." Blood. 101: 4797-801. 

35.) Sharp CD, Hines I, Houghton J, Warren A, Jackson TH 4th, Jawahar A, Nanda A, Elrod JW, Long A, Chi A, Minagar A, Alexander JS. (2003) "Glutamate causes a loss in human cerebral endothelial barrier integrity through activation of NMDA receptor." Am J Physiol Heart Circ Physiol. 285: H2592-98.
例如二:人脑血管平滑肌细胞(Human Brain Vascular Smooth Muscle Cells

1.) Kikkawa Y, Matsuo S, Kurogi R, Nakamizo A, Mizoguchi M, Sasaki T. (2014) 'Upregulation of Relaxin after Experimental Subarachnoid Hemorrhage in Rabbits.'

2.) Shi X, Fu Y, Liao D, Chen Y, Liu J. (2014) 'Alterations of Voltage-Dependent Calcium Channel Currents in Basilar Artery Smooth Muscle Cells at Early Stage of Subarachnoid Hemorrhage in a Rabbit Model.'

3.) Kikkawa Y, Matsuo S, Kurogi R, Nakamizo A, Mizoguchi M, Sasaki T. (2014) "Upregulation of Relaxin after Experimental Subarachnoid Hemorrhage in Rabbits." Biomed res int. 2014: 836397.

4.) Shi X, Fu Y, Liao D, Chen Y, Liu J. (2014) "Alterations of Voltage-Dependent Calcium Channel Currents in Basilar Artery Smooth Muscle Cells at Early Stage of Subarachnoid Hemorrhage in a Rabbit Model." PloS one. 9: e84129.

5.) Cucullo L, Hossain M, Tierney M, Janigro D. (2013) "A new dynamic in vitro modular capillaries-venules modular system: cerebrovascular physiology in a box." BMC Neurosci. 14: 18.

6.) Meng H, Zhang X, Lee SJ, Wang MM. (2013) "Von Willebrand Factor Inhibits Mature Smooth Muscle Gene Expression through Impairment of Notch Signaling." PLoS One. 8: e75808.

7.) Zuloaga KL, O

8.) Zuloaga KL, O

9.) Miners JS, Kehoe P, Love S. (2011). "Neprilysin protects against cerebral amyloid angiopathy and Abeta-induced degeneration of cerebrovascular smooth muscle cells." Brain Patholology. 21: 594-605

10.) Fossati S, Cam J, Meyerson J, Mezhericher E, Romero IA, Couraud PO, Weksler BB, Ghiso J, Rostagno A. (2010) "Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-beta variants in cells composing the cerebral vessel walls." FASEB J. 24: 229-41.

11.) Lefterov I, Fitz NF, Cronican AA, Fogg A, Lefterov P, Kodali R, Wetzel R, Koldamova R. (2010) "Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice." J Biol Chem 285: 36945-57.

12.) Kanekiyo T, Bu G. (2009) "Receptor-associated protein interacts with amyloid-beta peptide and promotes its cellular uptake." J Biol Chem. 284: 33352-59.

13.) Wang J, Tuo H, Wang R, Li W, Feng Z, Chen J, Wang D. (2008) "The expression of human brain vascular smooth muscle cell AT receptor after the UL83 gene of HCMV inhibition by small interfering RNAs." Neurol Res. 30: 903-09. 

例如三:人心脏成纤维细胞(Human Cardiac Fibroblasts
1.) Chida J, Araki H, Maeda Y. (2014) "Specific growth suppression of human cancer cells by targeted delivery of Dictyostelium mitochondrial ribosomal protein S4." Cancer cell int. 14: 56.

2.) Huntley BK, Ichiki T, Sangaralingham SJ, Chen HH, Burnett JC Jr. (2010) "B-type natriuretic peptide and extracellular matrix protein interactions in human cardiac fibroblasts." J Cell Physiol. 225: 251-5. 

3.) Lin CS, Pan CH, Wen CH, Yang TH, Kuan TC. (2010) "Regulation of angiotensin converting enzyme II by angiotensin peptides in human cardiofibroblasts." Peptides. 31: 1334-40. 

4.) Westenbrink BD, Ruifrok WP, Voors AA, Tilton RG, van Veldhuisen DJ, Schoemaker RG, van Gilst WH, de Boer RA. (2010) "Vascular endothelial growth factor is crucial for erythropoietin-induced improvement of cardiac function in heart failure." Cardiovasc Res. 87: 30-9.

5.) Huntley BK, Ichiki T, Sangaralingham SJ, Chen HH, Burnett JC. (2010) "B?type natriuretic peptide and extracellular matrix protein interactions in human cardiac fibroblasts." J of cell physiol. 225: 251-55.

6.) McKie PM, Cataliotti A, Huntley BK, Martin FL, Olson TM, Burnett JC Jr. (2009) "A human atrial natriuretic peptide gene mutation reveals a novel peptide with enhanced blood pressure-lowering, renal-enhancing, and aldosterone-suppressing actions." J Am Coll Cardiol. 54: 1024-32.

7.) Lisy O, Huntley BK, McCormick DJ, Kurlansky PA, Burnett JC Jr. (2008) "Design, synthesis, and actions of a novel chimeric natriuretic peptide: CD-NP." J Am Coll Cardiol. 52: 60-8. 

8.) Pan CH, Wen CH, Lin CS. (2008) "Interplay of angiotensin II and angiotensin(1-7) in the regulation of matrix metalloproteinases of human cardiocytes." Exp Physiol. 93: 599-612. 

9.) Reddy VS, Harskamp RE, van Ginkel MW, Calhoon J, Baisden CE, Kim IS, Valente AJ, Chandrasekar B. (2008) "Interleukin-18 stimulates fibronectin expression in primary human cardiac fibroblasts via PI3K-Akt-dependent NF-kappaB activation." J Cell Physiol. 215: 697-707.

10.) Saxena A, Fish JE, White MD, Yu S, Smyth JW, Shaw RM, DiMaio JM, Srivastava D. (2008) "Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction." Circulation. 117: 2224-31.

11.) Bunda S, Liu P, Wang Y, Liu K, Hinek A. (2007) "Aldosterone induces elastin production in cardiac fibroblasts through activation of insulin-like growth factor-I receptors in a mineralocorticoid receptor-independent manner." Am J Pathol. 171: 809-19.

12.) Cortez DM, Feldman MD, Mummidi S, Valente AJ, Steffensen B, Vincenti M, Barnes JL, Chandrasekar B. (2007) "IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation." Am J Physiol Heart Circ Physiol. 293: H3356-65.

13.) Noser JA, Mael AA, Sakuma R, Ohmine S, Marcato P, Lee PW, Ikeda Y. (2007) "The RAS/Raf1/MEK/ERK Signaling Pathway Facilitates VSV-mediated Oncolysis: Impli cation for the Defective Interferon Response in Cancer Cells." Mol Ther. 15: 1531-6. 

14.) Huntley BK, Sandberg SM, Noser JA, Cataliotti A, Redfield MM, Matsuda Y, Burnett JC Jr. (2006) "BNP-induced activation of cGMP in human cardiac fibroblasts: Interactions with fibronectin and natriuretic peptide receptors." J Cell Physiol. 209: 943-9.

例如四:人角膜上皮细胞(Human Corneal Epithelial Cells

1.) Vellonen KS, H?kli M, Merezhinskaya N, Tervo T, Honkakoski P, Urtti A. (2010) "Monocarboxylate transport in human corneal epithelium and cell lines." Eur J Pharm Sci. 39: 241-7.

2.) Vellonen KS, Mannermaa E, Turner H, H?kli M, Wolosin JM, Tervo T, Honkakoski P, Urtti A. (2010) "Effluxing ABC transporters in human corneal epithelium." J Pharm Sci. 99: 1087-98.

3.) Belser JA, Wadford DA, Xu J, Katz JM, Tumpey TM. (2009) "Ocular infection of mice with influenza A (H7) viruses: a site of primary replication and spread to the respiratory tract." J Virol. 283: 7075-84. 

4.) Cheong HI, Johnson J, Cormier M, Hosseini K. (2008) "In vitro cytotoxicity of eight beta-blockers in human corneal epithelial and retinal pigment epithelial cell lines: comparison with epidermal keratinocytes and dermal fibroblasts." Toxicol In Vitro. 22: 1070-6. 

5.) Reichl S. (2008) "Cell culture models of the human cornea - a comparative evaluation of their usefulness to determine ocular drug absorption in-vitro." J Pharm Pharmacol. 60: 299-307. 

6.) Zhang JZ, Cavet ME, Ward KW. (2008) "Anti-inflammatory effects of besifloxacin, a novel fluoroquinolone, in primary human corneal epithelial cells." Curr Eye Res. 33: 923-32.

7.) Hunt DW, Boivin WA, Fairley LA, Jovanovic MM, King DE, Salmon RA, Utting OB. (2006) "Ultraviolet B light stimulates interleukin-20 expression by human epithelial keratinocytes." Photochem Photobiol. 82: 1292-300.
例如五:人神经元细胞 (Human Neurons)
1.) Chu S, Ma Y, Feng D, Li Z, Jiang P. (2013) "Predictive value of the SLC22A18 protein expression in glioblastoma patients receiving temozolomide therapy." J Transl Med. 11: 69.

2.) Deshmane SL, Mukerjee R, Fan S, Sawaya BE. (2011) "High-performance capillary electrophoresis for determining HIV-1 Tat protein in neurons." PLoS One. 6: e16148. 

3.) Saiyed ZM, Gandhi N, Agudelo M, Napuri J, Samikkannu T, Reddy PV, Khatavkar P, Yndart A, Saxena SK, Nair MP. (2011) "HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: Implication for HIV-associated neurocognitive disorder (HAND)." Neurochem Int. 58: 656-64. 

4.) Gouras GK, Tampellini D, Takahashi RH, Capetillo-Zarate E. (2010) "Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease." Acta Neuropathol. 119: 523-41.

5.) Mak YT, Lam WP, L? L, Wong YW, Yew DT. (2010) "The toxic effect of ketamine on SH-SY5Y neuroblastoma cell line and human neuron." Microsc Res Tech. 73: 195-201.

6.) Lee CT, Lehrmann E, Hayashi T, Amable R, Tsai SY, Chen J, Sanchez JF, Shen J, Becker KG, Freed WJ. (2009) "Gene Expression Profiling Reveals Distinct Cocaine-Responsive Genes in Human Fetal CNS Cell Types." J Addict Med. 3: 218-26. 

7.) Lee CT,?Chen J,?Hayashi T,?Tsai SY,?Sanchez JF,?Errico SL,?Amable R,?Su TP,?Lowe RH,?Huestis MA,?Shen J,?Becker KG,?Geller HM,?Freed WJ. (2008) "A?mechanism?for the?inhibition?of?neural?progenitor?cell?proliferation?by?cocaine." PLoS Med. 5: e117 

8.) Karmakar S, Banik NL, Patel SJ, Ray SK. (2007) "Garlic compounds induced calpain and intrinsic caspase cascade for apoptosis in human malignant neuroblastoma SH-SY5Y cells." Apoptosis. 12: 671-84.

9.) Michaelis M, Kleinschmidt MC, Doerr HW, Cinatl J Jr. (2007) "Minocycline inhibits West Nile virus replication and apoptosis in human neuronal cells." J Antimicrob Chemother. 60: 981-6.

10.) Cassiani-Ingoni R, Cabral ES, L?nemann JD, Garza Z, Magnus T, Gelderblom H, Munson PJ, Marques A, Martin R. (2006) "Borrelia burgdorferi induces TLR1 and TLR2 in human microglia and peripheral blood monocytes but differentially regulates HLA-Class II expresssion." Journal of Neupathology & Experimental Neurology. 65: 540-48.

11.) Padmanabhan J, Levy M, Dickson DW, Potter H. (2006) "Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons." Brain. 129: 3020-34. 

12.) Hashimoto M, Bar-On P, Ho G, Takenouchi T, Rockenstein E, Crews L, Masliah E. (2004) "Synuclein Regulates Akt Activity in Neuronal Cells-a possible mechanism for neuroprotecton in parkinson's disease." J Biol Chem. 279: 23622-9. 

例如六:人间充质干细胞--骨髓 (
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