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人神经元
英文名:Human Neurons
货号:1520
价格:¥12258.00
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人神经元细胞描述:

        中枢神经系统的组织由两类细胞组成,它们可以广义地分为神经元和神经胶质。神经元是大脑在解剖、功能及营养上的单元。尽管神经元的大小和形状有很大的差异,但它们都具有共同的形态学特征,而且它们是复杂通信网络中的重要物质。神经元是动态极化的细胞,并且是神经系统中的主要信号物质。人类大脑包含1 x 1011 神经元,而且每个神经元至少可与10000个其它神经元互通信息。

        人神经元细胞(HN)提取于人脑组织,原代培养冻存。每管含有细胞数>5×106 cells/ml,此细胞通过Neurafilament, MAP2, 和 beta-tubulin III免疫荧光染色验证,经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。 

推荐培养基:神经细胞培养基NM, Cat. No. 1521

产品使用说明:仅供科研研究使用

货号 1520
产地 美国
缩写 HN
规格 1 x 10^6 cells/vial
用途 科研
运输 干冰
保存 液氮

1.) Zhou, Y., Zhang, H., Zheng, B., Ye, L., Zhu, S., Johnson, N.R., Wang, Z., Wei, X., Chen, D., Cao, G., Fu, X., Li, X., Xu, H.Z. & Xiao, J. (2016) Retinoic Acid Induced-Autophagic Flux Inhibits ER-Stress Dependent Apoptosis and Prevents Disruption of Blood-Spinal Cord Barrier after Spinal Cord Injury Int J Biol Sci. 12

2.) Olsson, M., Hultman, K., Dunoyer-Geindre, S., Curtis, M.A., Faull, R.L.M., Kruithof, E.K.O. & Jern, C. (2016) Epigenetic Regulation of Tissue-Type Plasminogen Activator in Human Brain Tissue and Brain-Derived Cells Gene Regul Syst Bio. 10

3.) Watanabe, S., Ohno, S., Shirogane, Y., Suzuki, S.O., Koga, R. & Yanagi, Y. (2015) Measles Virus Mutants Possessing the Fusion Protein with Enhanced Fusion Activity Spread Effectively in Neuronal Cells, but Not in Other Cells, without Causing Strong Cytopathology J Virol. 89

4.) Li, J., Zhou, J., Zhang, D., Song, Y., She, J. & Bai, C. (2015) Bone marrow-derived mesenchymal stem cells enhance autophagy via PI3K/AKT signalling to reduce the severity of ischaemia/reperfusion-induced lung injury J Cell Mol Med. 19

5.) Chu S, Ma Y, Feng D, Li Z, Jiang P. (2013) "Predictive value of the SLC22A18 protein expression in glioblastoma patients receiving temozolomide therapy." J Transl Med. 11: 69.

6.) Agudelo, M., Yoo, C. & Nair, M.P. (2012) Alcohol-induced serotonergic modulation: the role of histone deacetylases Alcohol. 46

7.) Deshmane SL, Mukerjee R, Fan S, Sawaya BE. (2011) "High-performance capillary electrophoresis for determining HIV-1 Tat protein in neurons." PLoS One. 6: e16148. 

8.) Saiyed ZM, Gandhi N, Agudelo M, Napuri J, Samikkannu T, Reddy PV, Khatavkar P, Yndart A, Saxena SK, Nair MP. (2011) "HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: Implication for HIV-associated neurocognitive disorder (HAND)." Neurochem Int. 58: 656-64. 

9.) Gouras GK, Tampellini D, Takahashi RH, Capetillo-Zarate E. (2010) "Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease." Acta Neuropathol. 119: 523-41.

10.) Mak YT, Lam WP, L L, Wong YW, Yew DT. (2010) "The toxic effect of ketamine on SH-SY5Y neuroblastoma cell line and human neuron." Microsc Res Tech. 73: 195-201.

11.) Lee CT, Lehrmann E, Hayashi T, Amable R, Tsai SY, Chen J, Sanchez JF, Shen J, Becker KG, Freed WJ. (2009) "Gene Expression Profiling Reveals Distinct Cocaine-Responsive Genes in Human Fetal CNS Cell Types." J Addict Med. 3: 218-26. 

12.) Lee CT, Chen J, Hayashi T, Tsai SY, Sanchez JF, Errico SL, Amable R, Su TP, Lowe RH, Huestis MA, Shen J, Becker KG, Geller HM, Freed WJ. (2008) "A mechanism for the inhibition of neural progenitor cell proliferation by cocaine." PLoS Med. 5: e117

13.) Karmakar S, Banik NL, Patel SJ, Ray SK. (2007) "Garlic compounds induced calpain and intrinsic caspase cascade for apoptosis in human malignant neuroblastoma SH-SY5Y cells." Apoptosis. 12: 671-84.

14.) Michaelis M, Kleinschmidt MC, Doerr HW, Cinatl J Jr. (2007) "Minocycline inhibits West Nile virus replication and apoptosis in human neuronal cells." J Antimicrob Chemother. 60: 981-6.

15.) Cassiani-Ingoni R, Cabral ES, L?nemann JD, Garza Z, Magnus T, Gelderblom H, Munson PJ, Marques A, Martin R. (2006) "Borrelia burgdorferi induces TLR1 and TLR2 in human microglia and peripheral blood monocytes but differentially regulates HLA-Class II expresssion." Journal of Neupathology & Experimental Neurology. 65: 540-48.

16.) Padmanabhan J, Levy M, Dickson DW, Potter H. (2006) "Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons." Brain. 129: 3020-34. 

17.) Hashimoto M, Bar-On P, Ho G, Takenouchi T, Rockenstein E, Crews L, Masliah E. (2004) "Synuclein Regulates Akt Activity in Neuronal Cells-a possible mechanism for neuroprotecton in parkinson's disease." J Biol Chem. 279: 23622-9. 

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1 Answer
I was wondering what information was available on the source of the neurons, such as age, gender, brain region, and health (for example any diseases or known genetic conditions)?
Posted by Rachel Hodge, Tuesday, February 2, 2016 on product Human Neurons

Question:
I was wondering what information was available on the source of the neurons, such as age, gender, brain region, and health (for example any diseases or known genetic conditions)?

Answers:
Posted by Manoj Sharma on Tuesday, February 2, 2016
ScienCell is always happy to provide any donor information we have on our inventory.  As it is always changing please email us at info@sciencellonline.com for updated donor information on this catalog item.  
thank you for your interest in our products
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