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大鼠脑周细胞
英文名:Rat Brain Vascular Pericytes
货号:R1200
价格:¥9360.00
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大鼠脑周细胞


Brain Vascular Pericytes (BVP) are perivascular cells that are closely associated with the endothelium of capillaries and other small vessels [1]. BVP, located between endothelial cells and astrocytes in the brain, communicate with other cells by extending long cytoplasmic processes which wrap around the capillaries [1, 2]. BVP participate in a variety of processes including angiogenesis, endothelial cell survival, regulation of capillary blood flow, and establishment and maintenance of the blood-brain barrier [3, 4]. Pericyte dysregulation has been linked to several pathological conditions such as hypertension, diabetic retinopathy, atherosclerosis, multiple sclerosis, Alzheimer’s disease, and tumor angiogenesis [2, 4]. The unique and diverse functions of BVP make them novel candidates for cell therapy in regenerative medicine. Cultured primary rat BVP (RBVP) are a useful in vitro model for understanding the molecular mechanisms of blood-brain barrier regulation and for studying a wide variety of central nervous system diseases.


RBVP from ScienCell Research Laboratories are isolated from adult rat brain. RBVP are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. RBVP are characterized by immunofluorescence with antibody specific to platelet-derived growth factor-ß (PDGF receptor-ß) and α-smooth muscle actin. RBVP are negative for mycoplasma, bacteria, yeast, and fungi. RBVP are guaranteed to further expand for 5 population doublings under the conditions provided by ScienCell Research Laboratories.


Recommended Medium

It is recommended to use Pericyte Medium (PM, Cat. #1201) for culturing RBVP in vitro.

货号 R1200
产地 美国
缩写 RBVP
规格 5 x 10^5 cells/vial
用途 科研
运输 干冰
保存 液氮
[1] Dore-Duffy P, Cleary K. (2011) "Morphology and properties of pericytes." Methods Mol Biol. 686:49-68.
[2] Allt G, Lawrenson JG. (2001) "Pericytes: cell biology and pathology." Cells Tissues Organs. 169: 1-11.
[3] Daneman R, Zhou L, Kebede A, Barres B. (2010) "Pericytes are required for blood-brain barrier integrity during embryogenesis." Nature. 468:562-566.
[4] Kutcher M, Herman I. (2009) "The pericyte: cellular regulator of microvascular blood flow." Microvasc Res. 77: 235-246.
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上海中乔新舟生物科技有限公司
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