产品名称	Caco-2人结肠腺癌细胞
货号	ZQ0056
产品介绍	Caco-2[Caco2]是一种人结肠腺癌细胞系，最初是从一位72岁男性患者的直肠原位癌组织中分离出来建立的。这些细胞在体外培养时，能够分化成类似小肠上皮细胞的形态，表现出微绒毛等结构，当细胞长满时，可表现出具有分化的肠上皮细胞的特征。Caco-2细胞因其与小肠上皮细胞在结构和功能上的相似性，被广泛用于模拟体内肠道吸收和转运的实验。因其在模拟人类肠道吸收和转运方面的能力，已成为研究药物代谢和口服生物利用度的重要工具。细胞表达维甲酸结合蛋白I和维甲酸结合蛋白II。 【注意事项】： 1. 复苏或传代后细胞贴壁较慢，大量细胞会漂浮并存在一些碎片，最终会以岛状形态贴壁并扩散生长。为了避免干扰细胞贴壁，48小时内不要换液；细胞形态不均一，有一些含有液泡的巨大细胞，该细胞培养过程中会有黑色颗粒物，属正常现象；消化时间 5-10 min。 2. 该细胞对血清质量较为敏感，我司建议您使用品牌优质胎牛血清进行培养或选择订购我司配套Caco-2完全培养液。
种属	人
性别/年龄	男/72岁
组织	结肠
疾病	结肠直肠腺癌
细胞类型	肿瘤细胞
形态学	上皮样
生长方式	贴壁；细胞形态不均一，有部分含有液泡的巨大细胞
倍增时间	大约32~80小时
培养基和添加剂	RPMI-1640基础培养基（中乔新舟 货号：ZQ-200）+10%胎牛血清 (中乔新舟 货号：ZQ0500）+1%P/S（货号：CSP006）
推荐完全培养基货号	ZM0056
生物安全等级	BSL-1
STR位点信息	Amelogenin: X D3S1358: 14,17 TH01: 6 D21S11: 30,32 D18S51: 12 Penta_E: 7 D5S818: 12,13 D13S317: 11,13,14 D7S820: 11,12 D16S539: 12,13 CSF1PO: 11 Penta_D: 9,11 vWA: 16,18 D8S1179: 12,14 TPOX: 9,11 FGA: 19 D19S433: 15 D2S1338: 17,25
培养条件	95%空气，5%二氧化碳；37℃
抗原表达/受体表达	***
基因表达	***
保藏机构	ATCC; HTB-37 BCRJ; 0059 DSMZ; ACC-169 ECACC; 09042001 ECACC; 86010202
供应限制	仅供科研使用

货号	ZQ0056
发货规格	活细胞：T25培养瓶*1瓶或者1ml 冻存管*1支（细胞量约为5 x 10^5 cells/vial）二选一
发货形式	活细胞：常温运输；冻存管：干冰运输
储存温度	活细胞：培养箱；冻存管：液氮罐
产地	中国
供应限制	仅供科研使用

论文标题： Bioaccumulation of differently-sized polystyrene nanoplastics by human lung and intestine cells
DOI： 10.1016/j.jhazmat.2022.129585
发表时间： 2022-07-12
期刊： JOURNAL OF HAZARDOUS MATERIALS
影响因子： 14.224
货号： ZQ0056
产品名称： Caco-2 cells
原文链接： https://www.sciencedirect.com/science/article/pii/S0304389422013784

论文标题： Oral absorption characteristics and mechanisms of a pectin-type polysaccharide from Smilax china L. across the intestinal epithelium
DOI： 10.1016/j.carbpol.2021.118383
发表时间： 2021-06-29
期刊： CARBOHYDRATE POLYMERS
影响因子： 9.381
货号： ZQ0056
产品名称： Caco-2 cells
原文链接： https://www.sciencedirect.com/science/article/pii/S0144861721007700

论文标题： Tracking the gastrointestinal digestive and metabolic behaviour of Dendrobium officinale polysaccharides by fluorescent labelling
DOI： 10.1039/D2FO01506D
发表时间： 2022-06-10
期刊： Food & Function
影响因子： 6.317
货号： ZQ0056
产品名称： Caco-2 cells
原文链接： https://pubs.rsc.org/en/content/articlelanding/2022/fo/d2fo01506d

论文标题： Study on the bioaccessibility and bioavailability of perchlorate in different food matrices in vitro
DOI： 10.1016/j.foodchem.2020.127470
发表时间： 2020-07-04
期刊： FOOD CHEMISTRY
影响因子： 6.306
货号： ZQ0056
产品名称： Caco-2 cell line
原文链接： https://www.sciencedirect.com/science/article/pii/S0308814620313327

论文标题： Knockdown of SFRS9 Inhibits Progression of Colorectal Cancer Through Triggering Ferroptosis Mediated by GPX4 Reduction
DOI： 10.3389/fonc.2021.683589
发表时间： 2021-07-16
期刊： Frontiers in Oncology
影响因子： 6.244
货号： ZQ0056
产品名称： Caco-2 cells

原文链接： https://www.ncbi.nlm.nih.gov/pmc/articles/pmc8322952/

论文标题： Bioavailability Evaluation of Perchlorate in Different Foods In Vivo: Comparison with In Vitro Assays and Implications for Human Health Risk Assessment
DOI： 10.1021/acs.jafc.1c00539
发表时间： 2021-04-21
期刊： JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
影响因子： 5.279
货号： ZQ0056
产品名称： Caco-2 cells
原文链接： https://pubs.acs.org/doi/abs/10.1021/acs.jafc.1c00539

论文标题： Inhibition of SRSF9 enhances the sensitivity of colorectal cancer to erastin-induced ferroptosis by reducing glutathione peroxidase 4 expression
DOI： 10.1016/j.biocel.2021.105948
发表时间： 2021-02-17
期刊： INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
影响因子： 5.085
货号： ZQ0056
产品名称： Caco-2 cells
原文链接： https://www.sciencedirect.com/science/article/pii/S1357272521000327

论文标题： Self-Cross-Linked Hydrogel of Cysteamine-Grafted γ-Polyglutamic Acid Stabilized Tripeptide KPV for Alleviating TNBS-Induced Ulcerative Colitis in Rats
DOI： 10.1021/acsbiomaterials.1c00792
发表时间： 2021-09-21
期刊： ACS Biomaterials Science & Engineering
影响因子： 4.749
货号： ZQ0056
产品名称： Caco-2 cells
原文链接： https://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.1c00792

论文标题： MiR-346-5p promotes colorectal cancer cell proliferation in vitro and in vivo by targeting FBXL2 and activating the β-catenin signaling pathway
DOI： 10.1016/j.lfs.2020.117300
发表时间： 2020-01-14
期刊： LIFE SCIENCES
影响因子： 3.647
货号： ZQ0056
产品名称： Caco-2 cells
原文链接： https://www.sciencedirect.com/science/article/pii/S0024320520300473

论文标题： Salinomycin and Sulforaphane Exerted Synergistic Antiproliferative and Proapoptotic Effects on Colorectal Cancer Cells by Inhibiting the PI3K/Akt Signaling Pathway in vitro and in vivo
DOI： 10.2147/OTT.S246706
发表时间： 2020-06-03
期刊： OncoTargets and Therapy
影响因子： 3.337
货号： ZQ0056
产品名称： Caco-2 cells
原文链接： https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276212/

论文标题： Evaluation on absorption risks of amentoflavone after oral administration in rats
DOI： 10.1002/bdd.2304
发表时间： 2021-10-23
期刊： BIOPHARMACEUTICS & DRUG DISPOSITION
影响因子： 1.627
货号： ZQ0056
产品名称： Caco-2 cells
原文链接： https://onlinelibrary.wiley.com/doi/abs/10.1002/bdd.2304

论文标题： Anti-influenza A (H1N1) viral and cytotoxic sesquiterpenes from Carpesium abrotanoides
DOI： 10.1016/j.phytol.2019.10.013
发表时间： 2019-11-15
期刊： Phytochemistry Letters
影响因子： 1.338
货号： ZQ0056
产品名称： Caco-2 cells

原文链接： https://www.sciencedirect.com/science/article/pii/S187439001930518X

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