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NCI-H441人肺腺癌细胞 (STR鉴定)

英文名:NCI-H441
货号:ZQ0624
价格:¥1200.00
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NCI-H441人肺腺癌细胞 (STR鉴定)

¥1200.00
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NCI-H441人肺腺癌细胞专用培养基

¥350.00 ¥450.00

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细胞套餐惊爆价

¥1550 ¥3650.00
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  • 产品说明
  • 产品规格
  • 参考文献
  • STR鉴定

产品名称

NCI-H441 人肺腺癌细胞

货号

ZQ0624

产品介绍

NCI-H441细胞系,也称为H441,是由A.F. Gazdar、M. Brower和D. Carney等人于1982年从一位患有肺乳头状腺癌的男性患者的胸水中建立的细胞系。这是一种经过良好特征化的上皮腺癌细胞系。这些细胞因其与肺上皮生物学的相关性,在生物研究中被广泛使用,是研究跨上皮运输和上皮屏障功能的体外模型。

NCI-H441细胞系是增进我们对肺部药物处置和肿瘤动力学理解的重要工具。在3D细胞培养模型中的使用,允许详细研究药物在肺部环境中的吸收、分布、代谢和排泄,密切模拟体内条件。

鉴于它们的起源和特性,NCI-H441细胞在专注于远端肺和相关疾病(包括肺腺癌)的研究中特别有价值,作为理解肺部疾病机制和评估潜在治疗干预的稳定和相关细胞模型。

NCI-H441细胞在3D细胞培养、高通量筛选和毒理学研究中发挥着重要作用,为细胞反应和治疗剂的有效性提供了宝贵的数据。人类细胞系H441的一个显著应用是作为转染宿主,用于表达肺表面活性蛋白(SP-B),利用萤火虫荧光素酶报告系统,这强调了它们在吸入生物药剂学和跨上皮运输研究中的作用。这种能力,加上它们对主要表面活性物质载脂蛋白(SP-A)的mRNA和蛋白的表达,突出了细胞系在研究肺功能和疾病中的重要性,特别是那些影响表面活性物质调节和合成的疾病

种属

性别/年龄

男/33岁

组织

疾病

乳头状腺癌

细胞类型

肿瘤细胞

形态学

上皮的

生长方式

贴壁

倍增时间

大约46.5~138小时

培养基和添加剂

RPMI-1640(品牌:中乔新舟 货号:ZQ-200+10%胎牛血清(中乔新舟 货号:ZQ0500+1%P/S(中乔新舟  货号:CSP006

推荐完全培养基货号

ZM0624

生物安全等级

BSL-1

STR位点信息

Amelogenin: X,Y

CSF1PO: 11,12

D13S317: 9

D16S539: 9,13

D5S818: 11,12

D7S820: 10

THO1: 9.3

TPOX: 8,10

vWA: 17

培养条件

95%空气,5%二氧化碳;37℃

抗原表达/受体表达

*** 

基因表达

*** 

保藏机构

ATCC; HTB-174 ATCC; CRM-HTB-174 BCRC; 60455 
BCRJ; 0359 

供应限制

仅供科研使用

货号

ZQ0624

发货规格

活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一

发货形式

活细胞:常温运输;冻存管:干冰运输

储存温度

活细胞:培养箱;冻存管:液氮罐

产地

中国

供应限制

仅供科研使用


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Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

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