产品名称	MCF-7人乳腺癌细胞
货号	ZQ0071
产品介绍	MCF-7是一种人类乳腺癌细胞系，最初是从一位名叫Helen Marion的修女的胸腔积液中分离出来的。保留了乳腺上皮的分化特性，包括：能通过胞质雌激素受体加工雌二醇；含有Tx-4癌基因；肿瘤坏死因子α(TNFalpha)可以抑制MCF-7细胞的生长。抗雌激素处理细胞能调节IGFBPs的分泌。这个细胞系也因其在雌激素受体（ER）α研究中的重要性而被广泛使用，因为它是少数表达大量ER的细胞系之一，模仿了大多数侵袭性人类乳腺癌的特点。因其独特的生物学特性，在乳腺癌治疗研究中有着广泛的应用，例如：药物敏感性研究、基因组学研究、耐药性机制研究、基因功能研究、细胞信号传导研究、癌症转移研究、癌症干细胞研究、药物组合研究、精准医疗研究等。这些应用展示了MCF-7细胞系在乳腺癌治疗研究中的多样性和重要性，是乳腺癌研究的基石，它不仅帮助科学家们理解了乳腺癌的生物学特性，还促进了新治疗方法的发展。尽管存在局限性，但MCF-7细胞系预计仍将是未来乳腺癌研究的重要资源。 【注意事项】： 1. 该细胞贴壁较慢，建议复苏、传代后让细胞贴壁48-72h后再进行后续实验操作。 2. 使用0.25%(w/v) Trypsin-0.53 mM EDTA消化细胞。 3. MCF7是一种生长缓慢的细胞系，它会以松散的三维团簇的形式出现，并伴有一些漂浮的活细胞。悬浮的活细胞可以通过离心后重新加入到培养瓶中培养。在复苏后前二代该细胞会出现贴壁缓慢的情况，是正常现象。松散的三维团簇细胞慢慢会扩散形成一个扁平的单层细胞。 4. 如果生长速度比正常情况慢，可以尝试另一批FBS（即血清批次的促生长能力可能不同）。此外，将血清浓度增加到20％也可能有助于改善生长。 复苏时密度在8.0 x 104 - 1.5 x 105活细胞/cm2之间；传代时接种密度，在4.0 x 104 - 1.0 x 105活细胞/cm2之间。 一般来说，当开始培养MCF-7 时，如果观察到一些悬浮着的细胞或者小的细胞团，在传代时候，需要将这些悬浮的细胞或者小细胞团保留，跟贴壁细胞一起培养， 经过几天的培养后，这些细胞应该会重新贴附在培养瓶上并连接在一起，呈现叠层成岛状（dome）生长。随后，细胞会沿着这些岛边缘，向外生长扩散，在两次传代后，细胞应该会铺展开来，一般6-12天可以达到70-80%的密度。 对于T-25瓶培养, 客户首先按传代密度扩增，制备冻管5支左右，然后开始培养实验用细胞，当传代发现细胞增殖或形态异常时，终止传代，重新复苏细胞。实验用细胞控制传代频率，代数不宜超过5次。
种属	人
性别/年龄	女/69岁
组织	乳腺、胸；分离自转移灶：胸腔积液
疾病	非特殊类型的浸润性乳腺癌
细胞类型	肿瘤细胞
形态学	上皮细胞
生长方式	贴壁
倍增时间	大约24~80小时
培养基和添加剂（默认）	MEM（含NEAA）（中乔新舟  货号：ZQ-300）+10%胎牛血清（中乔新舟  货号：ZQ0500）+1%双抗（中乔新舟   货号：CSP006）+1%L-alanyl-L-glutamine（中乔新舟  货号：CSP004）+1%SP（中乔新舟  货号：CSP003）+10ug/mL human recombinant insulin（中乔新舟   货号：CSP001-10）
培养方案B（可选）	DMEM (中乔新舟  货号：ZQ-100)+10%胎牛血清（中乔新舟  货号：ZQ500-A）+1%双抗（中乔新舟   货号：CSP006）
推荐默认完全培养基货号	ZM0071
B方案完全培养基货号	ZM0071-B
生物安全等级	BSL-1
STR位点信息	Amelogenin: X D3S1358: 16 TH01: 6 D21S11: 30 D18S51: 14 Penta_E: 7,12 D5S818: 11,12 D13S317: 11 D7S820: 8,9 D16S539: 11,12 CSF1PO: 10 Penta_D: 12 vWA: 14,15 D8S1179: 10,14 TPOX: 9,12 FGA: 23,25 D19S433: 13,14 D2S1338: 21,23
培养条件	95%空气，5%二氧化碳；37℃
抗原表达/受体表达	***
基因表达	***
保藏机构	ATCC; CRL-12584 ATCC; HTB-22 BCRC; 60436 BCRJ; 0162 DSMZ; ACC-115 ECACC; 86012803
供应限制	仅供科研使用

货号	ZQ0071
发货规格	活细胞：T25培养瓶*1瓶或者1ml 冻存管*1支（细胞量约为5 x 10^5 cells/vial）二选一
发货形式	活细胞：常温运输；冻存管：干冰运输
储存温度	活细胞：培养箱；冻存管：液氮罐
产地	中国
供应限制	仅供科研使用

1、论文标题： Bacteria eat nanoprobes for aggregation-enhanced imaging and killing diverse microorganisms
DOI： 10.1038/s41467-022-28920-6
发表时间： 2022-03-10
期刊： Nature Communications
影响因子： 14.919
货号： ZQ0071
产品名称： MCF-7 cells
原文链接： https://www.nature.com/articles/s41467-022-28920-6

2、论文标题： A metabolic acidity-activatable calcium phosphate probe with fluorescence signal amplification capabilities for non-invasive imaging of tumor malignancy
DOI： 10.1016/j.scib.2021.11.003
发表时间： 2021-11-03
期刊： Science Bulletin
影响因子： 11.78
货号： ZQ0071
产品名称： MCF-7 cells
原文链接： https://www.sciencedirect.com/science/article/pii/S2095927321006952

3、论文标题： A molybdenum oxide-based degradable nanosheet for combined chemo-photothermal therapy to improve tumor immunosuppression and suppress distant tumors and lung metastases
DOI： 10.1186/s12951-021-01162-2
发表时间： 2021-12-19
期刊： JOURNAL OF NANOBIOTECHNOLOGY
影响因子： 10.435
货号： ZQ0071
产品名称： MCF-7 cells
原文链接： https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-021-01162-2

4、论文标题： Prognostic value of gamma-interferon-inducible lysosomal thiol reductase expression in female patients diagnosed with breast cancer
DOI： 10.1002/ijc.33843
发表时间： 2021-10-25
期刊： INTERNATIONAL JOURNAL OF CANCER
影响因子： 7.396
货号： ZQ0071
产品名称： MCF-7 cells
原文链接： https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.33843

5、论文标题： Anti-tumor potential of astragalus polysaccharides on breast cancer cell line mediated by macrophage activation
DOI： 10.1016/j.msec.2019.01.025
发表时间： 2019-01-08
期刊： Materials Science & Engineering C-Materials for Biological Applications
影响因子： 7.328
货号： ZQ0071
产品名称： MCF-7 cells
原文链接： https://www.sciencedirect.com/science/article/pii/S0928493117347409

6、论文标题： Fabrication and characterization of novel cRGD modified graphene quantum dots for chemo-photothermal combination therapy
DOI： 10.1016/j.snb.2020.127732
发表时间： 2020-01-23
期刊： SENSORS AND ACTUATORS B-CHEMICAL
影响因子： 7.1
货号： ZQ0071
产品名称： MCF-7 (human breast cancer) cell lines
原文链接： https://www.sciencedirect.com/science/article/pii/S0925400520300794

7、论文标题： Evaluation of anti-tumor effects of crocin on a novel 3D tissue-engineered tumor model based on sodium alginate/gelatin microbead
DOI： 10.1016/j.ijbiomac.2021.01.181
发表时间： 2021-01-30
期刊： INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
影响因子： 6.953
货号： ZQ0071
产品名称： MCF-7 cells
原文链接： https://www.sciencedirect.com/science/article/pii/S0141813021002294

8、论文标题： Evaluation of inhibitory effects of geniposide on a tumor model of human breast cancer based on 3D printed Cs/Gel hybrid scaffold
DOI： 10.1016/j.msec.2020.111509
发表时间： 2020-09-11
期刊： Materials Science & Engineering C-Materials for Biological Applications
影响因子： 5.88
货号： ZQ0071
产品名称： MCF-7 cells
原文链接： https://www.sciencedirect.com/science/article/pii/S0928493120334275

9、论文标题： The m6A methyltransferase METTL3 controls epithelial-mesenchymal transition, migration and invasion of breast cancer through the MALAT1/miR-26b/HMGA2 axis
DOI： 10.1186/s12935-021-02113-5
发表时间： 2021-08-21
期刊： Cancer Cell International
影响因子： 5.722
货号： ZQ0071
产品名称： MCF-7 cells
原文链接： https://link.springer.com/article/10.1186/s12935-021-02113-5

10、论文标题： Long non-coding RNA ROR recruits histone transmethylase MLL1 to up-regulate TIMP3 expression and promote breast cancer progression
DOI： 10.1186/s12967-020-02682-5
发表时间： 2021-03-02
期刊： Journal of Translational Medicine
影响因子： 5.531
货号： ZQ0071
产品名称： MCF-7 cells
原文链接： https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02682-5

11、论文标题： MMP-2 sensitive poly(malic acid) micelles stabilized by π–π stacking enable high drug loading capacity
DOI： 10.1039/D0TB01682A
发表时间： 2020-08-11
期刊： Journal of Materials Chemistry B
影响因子： 5.344
货号： ZQ0071
产品名称： MCF-7 cells
原文链接： https://pubs.rsc.org/en/content/articlelanding/2020/tb/d0tb01682a

12、论文标题： lncRNA MALAT1 participates in metformin inhibiting the proliferation of breast cancer cell
DOI： 10.1111/jcmm.16742
发表时间： 2021-06-24
期刊： JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
影响因子： 5.31
货号： ZQ0071
产品名称： MCF7 cells

原文链接： https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.16742

13、论文标题： Construction and evaluation of red blood cells-based drug delivery system for chemo-photothermal therapy

DOI： 10.1016/j.colsurfb.2021.111789
发表时间： 2021-04-26
期刊： COLLOIDS AND SURFACES B-BIOINTERFACES
影响因子： 5.268
货号： ZQ0071
产品名称： MCF-7 cells
原文链接： https://www.sciencedirect.com/science/article/pii/S0927776521002332

14、论文标题： Multiple comparisons of three different sources of biomaterials in the application of tumor tissue engineering in vitro and in vivo
DOI： 10.1016/j.ijbiomac.2019.02.136
发表时间： 2019-02-23
期刊： INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
影响因子： 4.784
货号： ZQ0071
产品名称： MCF-7 cells
原文链接： https://www.sciencedirect.com/science/article/pii/S0141813019308189

15、论文标题： Cyclic arginine-glycine-aspartic acid-modified red blood cells for drug delivery: synthesis and in vitro evaluation

DOI： 10.1016/j.jpha.2021.06.003
发表时间： 2021-06-12
期刊： Journal of Pharmaceutical Analysis
影响因子： 4.769
货号： ZQ0071
产品名称： MCF-7 breast cancer cells
原文链接： https://www.sciencedirect.com/science/article/pii/S2095177921000630

16、论文标题： Multifunctional titanium phosphate carriers for enhancing drug delivery and evaluating real-time therapeutic efficacy of a hydrophobic drug component in Euphorbia kansui
DOI： 10.1039/D1AN00163A
发表时间： 2021-02-05
期刊： ANALYST
影响因子： 4.616
货号： ZQ0071
产品名称： MCF-7 cells
原文链接： https://pubs.rsc.org/en/content/articlelanding/2021/an/d1an00163a

17、论文标题： Dual-sensitized Eu(III)/Tb(III) complexes exhibiting tunable luminescence emission and their application in cellular-imaging
DOI： 10.1039/D2DT00051B
发表时间： 2022-01-24
期刊： DALTON TRANSACTIONS
影响因子： 4.569
货号： ZQ0071
产品名称： MCF-7 cells
原文链接： https://pubs.rsc.org/en/content/articlelanding/2022/dt/d2dt00051b

18、论文标题： Decellularized Pig Kidney with a Micro-Nano Secondary Structure Contributes to Tumor Progression in 3D Tumor Model

DOI： 10.3390/ma15051935
发表时间： 2022-03-04
期刊： Materials
影响因子： 3.623
货号： ZQ0071
产品名称： Human breast cancer MCF-7 cells
原文链接： https://www.mdpi.com/1529170

19、论文标题： METTL14 promotes the migration and invasion of breast cancer cells by modulating N6‑methyladenosine and hsa‑miR‑146a‑5p expression
DOI： 10.3892/or.2020.7515
发表时间： 2020-02-24
期刊： ONCOLOGY REPORTS
影响因子： 3.417
货号： ZQ0071
产品名称： MCF-7 cells
原文链接： https://www.spandidos-publications.com/10.3892/or.2020.7515

20、论文标题： SYK-targeted dendritic cell-mediated cytotoxic T lymphocytes enhance the effect of immunotherapy on retinoblastoma
DOI： 10.1007/s00432-018-2584-x
发表时间： 2018-01-25
期刊： JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
影响因子： 3.282
货号： ZQ0071
产品名称： MCF-7 cells
原文链接： https://link.springer.com/article/10.1007/s00432-018-2584-x

21、论文标题： Verteporfin inhibits cell proliferation and induces apoptosis in different subtypes of breast cancer cell lines without light activation
DOI： 10.1186/s12885-020-07555-0
发表时间： 2020-10-29
期刊： BMC CANCER
影响因子： 3.15
货号： ZQ0071
产品名称： MCF-7 cells
原文链接： https://bmccancer.biomedcentral.com/articles/10.1186/s12885-020-07555-0

22、论文标题： P16 promotes the growth and mobility potential of breast cancer both in vitro and in vivo: the key role of the activation of IL-6/JAK2/STAT3 signaling
DOI： 10.1007/s11010-018-3281-4
发表时间： 2018-01-31
期刊： MOLECULAR AND CELLULAR BIOCHEMISTRY
影响因子： 2.561
货号： ZQ0071
产品名称： MCF7 cells
原文链接： https://link.springer.com/article/10.1007/s11010-018-3281-4

23、论文标题： Amphiphilic Fluorine-Containing Block Copolymers as Carriers for Hydrophobic PtTFPP for Dissolved Oxygen Sensing, Cell Respiration Monitoring and In Vivo Hypoxia Imaging with High Quantum Efficiency and Long Lifetime
DOI： 10.3390/s18113752
发表时间： 2018-11-02
期刊： SENSORS
影响因子： 2.475
货号： ZQ0071
产品名称： MCF-7 cells
原文链接： https://www.mdpi.com/360560

24、论文标题： Determination of the migration effect and molecular docking of verteporfin in different subtypes of breast cancer cells
DOI： 10.3892/mmr.2020.11482
发表时间： 2020-09-02
期刊： Molecular Medicine Reports
影响因子： 2.1
货号： ZQ0071
产品名称： MCF-7 cells
原文链接： https://www.spandidos-publications.com/10.3892/mmr.2020.11482

25、论文标题： Long Non-Coding RNA A2M-AS1 Promotes Breast Cancer Progression by Sponging microRNA-146b to Upregulate MUC19
DOI： 10.2147/IJGM.S278564
发表时间： 2020-11-27
期刊： International Journal of General Medicine
影响因子： 1.927
货号： ZQ0071
产品名称： MCF-7 cells
原文链接： https://www.ncbi.nlm.nih.gov/pmc/articles/pmc7708314/

26、论文标题： Two new compounds from Carpesium abrotanoides
DOI： 10.1016/j.phytol.2020.08.012
发表时间： 2020-09-17
期刊： Phytochemistry Letters
影响因子： 1.459
货号： ZQ0071
产品名称： MCF-7 cells

原文链接： https://www.sciencedirect.com/science/article/pii/S187439002030639X

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