产品名称
EB-3人淋巴样Burkitt's淋巴瘤细胞
货号
ZQ0122
产品介绍
EB-3细胞系是一种源自3岁黑人男孩B淋巴细胞的人淋巴样Burkitt's淋巴瘤细胞系,该细胞系在体外培养时保持了其原始的淋巴母细胞样形态,并携带了Epstein-Barr病毒(EBV),EBNA阳性,这是Burkitt's淋巴瘤的一个重要特征。
Burkitt's淋巴瘤是一种高度侵袭性的非霍奇金淋巴瘤,主要影响B淋巴细胞,尤其在非洲儿童中的发病率较高。在研究应用方面,EB-3细胞系不仅有助于检查对放疗的生物学反应,丰富了我们对Burkitt's淋巴瘤生物学的理解,而且还是研究染色质修饰及其对细胞生物学影响的关键,特别是在肿瘤形成和癌症进展的背景下。EB-3细胞系是了解Burkitt's淋巴瘤的关键工具,为癌症生物学、治疗发展和肿瘤-免疫系统相互作用的复杂性提供了有价值的见解。
种属
人/3岁
性别/年龄
男性
组织
B型淋巴细胞,骨、颌、上颌骨,UBERON=UBERON_0002397.
疾病
EBV相关伯基特淋巴瘤(NCIt:C27694) ; 伯基特淋巴瘤(ORDO:Orphanet_543)
生物安全等级
BSL-2
STR位点信息
Amelogenin: X,Y
CSF1PO: 12,15
细胞类型
肿瘤细胞
形态学
淋巴母细胞样
生长方式
悬浮
倍增时间
大约48小时
培养基和添加剂
90%RPMI-1640(中乔新舟 货号:ZQ-200)+10%FBS(品牌:中乔新舟 货号:ZQ0500)++1%PS(中乔新舟 货号:CSP006)
推荐完全培养基货号
培养条件
37℃
抗原表达/受体表达
***
基因表达
***
保藏机构
ATCC、ECACC、DSMZ、
供应限制
仅供科研使用
D13S317: 12,14
D16S539: 10,12
D5S818: 9,10
D7S820: 11
TH01: 7
TPOX: 6,9
vWA: 17,19
D3S1358: 15,16
D21S11: 29
D18S51: 15,17
Penta_E: 14,16
Penta_D: 10,11
D8S1179: 14
FGA: 22
D19S433: 12.2,16.2
D2S1338: 17,22
货号 |
ZQ0122 |
发货规格 |
活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一 |
发货形式 |
活细胞:常温运输;冻存管:干冰运输 |
储存温度 |
活细胞:培养箱;冻存管:液氮罐 |
产地 |
中国 |
供应限制 |
仅供科研使用 |
1、PubMed=5884338
Epstein M.A., Barr Y.M., Achong B.G.
Studies with Burkitt's lymphoma.
Wistar Inst. Symp. Monogr. 4:69-82(1965)
2、PubMed=4169243; DOI=10.1093/jnci/39.5.1027
Klein G., Clifford P., Klein E., Smith R.T., Minowada J., Kourilsky F.M., Burchenal J.H.
Membrane immunofluorescence reactions of Burkitt lymphoma cells from biopsy specimens and tissue cultures.
J. Natl. Cancer Inst. 39:1027-1044(1967)
3、PubMed=6018567
Miles C.P., O'Neill F.
Chromosome studies of 8 in vitro lines of Burkitt's lymphoma.
Cancer Res. 27:392-402(1967)
4、PubMed=4894370; DOI=10.1002/1097-0142(196908)24:2<211::AID-CNCR2820240202>3.0.CO;2-3
Southam C.M., Burchenal J.H., Clarkson B.D. Sr., Tanzi A., Mackey R., McComb V.
Heterotransplantability of human cell lines derived from leukemia and lymphomas into immunologically tolerant rats.
Cancer 24:211-222(1969)
5、DOI=10.1007/BF02618370
Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.
The animal cell culture collection.
In Vitro 5:1-16(1970)
6、PubMed=4342611; DOI=10.1136/jcp.25.8.701
Marston S.D., Almond E.J.P., Bishun N.P., Maunsell E.D., Sutton R.N.P.
A 'virus-free' cell line derived from a patient with infectious mononucleosis.
J. Clin. Pathol. 25:701-704(1972)
7、PubMed=4736620; DOI=10.1111/j.1469-1809.1973.tb00588.x
Povey S., Gardiner S.E., Watson B., Mowbray S., Harris H., Arthur E., Steel C.M., Blenkinsop C., Evans H.J.
Genetic studies on human lymphoblastoid lines: isozyme analysis on cell lines from forty-one different individuals and on mutants produced following exposure to a chemical mutagen.
Ann. Hum. Genet. 36:247-266(1973)
8、PubMed=7316467; DOI=10.1111/j.1469-1809.1980.tb00953.x
Povey S., Jeremiah S., Arthur E., Steel M., Klein G.
Differences in genetic stability between human cell lines from patients with and without lymphoreticular malignancy.
Ann. Hum. Genet. 44:119-133(1980)
9、PubMed=6286763; DOI=10.4049/jimmunol.129.3.1336
Benjamin D., Magrath I.T., Maguire R.T., Janus C., Todd H.D., Parsons R.G.
Immunoglobulin secretion by cell lines derived from African and American undifferentiated lymphomas of Burkitt's and non-Burkitt's type.
J. Immunol. 129:1336-1342(1982)
10、PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 carboxylic esterase.
Leuk. Res. 9:209-229(1985)
11、PubMed=2998993
Steel C.M., Morten J.E.N., Foster E.
The cytogenetics of human B lymphoid malignancy: studies in Burkitt's lymphoma and Epstein-Barr virus-transformed lymphoblastoid cell lines.
IARC Sci. Publ. 60:265-292(1985)
12、PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)
13、PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)
14、PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)
15、PubMed=2052620; DOI=10.1073/pnas.88.12.5413
Gaidano G., Ballerini P., Gong J.Z., Inghirami G., Neri A., Newcomb E.W., Magrath I.T., Knowles D.M., Dalla-Favera R.
p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.
Proc. Natl. Acad. Sci. U.S.A. 88:5413-5417(1991)
16、CLPUB00447
Mulivor R.A., Suchy S.F.
17、PubMed=8515068; DOI=10.4049/jimmunol.150.12.5418
Jain V.K., Judde J.-G., Max E.E., Magrath I.T.
Variable IgH chain enhancer activity in Burkitt's lymphomas suggests an additional, direct mechanism of c-myc deregulation.
J. Immunol. 150:5418-5428(1993)
18、PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)
19、PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)
20、PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)
21、PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)
22、PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)
23、PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)
24、PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)
25、PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)
货号 | 产品名称 | 规格 | 价格 | 指令 |
ZQ0084 | Raji人Burkitts淋巴瘤细胞(STR鉴定) | 5 x 10^5 cells/vial | ¥1400.00 | 放入购物车 》 |
ZQ0432 | Daudi人Burkitts淋巴瘤细胞 | 5 x 10^5 cells/vial | ¥1350.00 | 放入购物车 》 |
ZQ0436 | JeKo-1人套细胞淋巴瘤细胞 (STR鉴定) | 5 x 10^5 cells/vial | ¥1800.00 | 放入购物车 》 |
ZQ505-K | 支原体检测试剂盒 | 1ml/100T | ¥800.00 | 放入购物车 》 |
ZQ506 | 支原体清除试剂盒 | 1ml | ¥600.00 | 放入购物车 》 |
A1001-1 | 国产转染试剂 | 1ml | ¥800.00 | 放入购物车 》 |
1 | 慢病毒介导基因沉默或过表达 | ¥询价 | 放入购物车 》 | |
5 | 荧光素酶标记 | ¥询价 | 放入购物车 》 | |
ZQ-200 | RPMI-1640基础培养基 | 500ml | ¥56.00 | 放入购物车 》 |
ZQ-201 | RPMI-1640完全培养基 | 500ml | ¥350.00 | 放入购物车 》 |
ZQ500-A | 优级胎牛血清 | 500ml | ¥2580(开学促销) | 放入购物车 》 |
JSFW-134 | 人源细胞STR鉴定服务 | ¥900.00 | 放入购物车 》 |