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786-O [786-0]人肾透明细胞腺癌细胞(STR鉴定)[套餐促销]

英文名:786-O [786-0]
货号:ZQ0338
价格:¥1350.00
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786-O [786-0]人肾透明细胞腺癌细胞(STR鉴定)[套餐促销]

¥1350.00
+

786-O人肾透明细胞腺癌细胞专用培养基

¥350.00 ¥480.00

配套完培,组合使用,省时省力

=

细胞套餐惊爆价

¥1700 ¥2080.00
加入购物车
  • 产品说明
  • 产品规格
  • 参考文献
  • STR鉴定

产品名称

786-O [786-0]人肾透明细胞腺癌细胞

货号

ZQ0338

产品介绍

786-O细胞是一种来源于原发性肾透明细胞腺癌的人肾细胞癌细胞系。 此细胞有微绒毛和桥粒,能在软琼脂是生长。 此细胞生成的一个PTH样的多肽与乳癌和肺癌中的肽相似。 这个多肽的N端与PTH相似,活性与PTH相似,分子量为6000道尔顿。该细胞系经常用于肾细胞癌(RCC)的研究,为这种癌症类型的生物学特性和治疗反应提供了有价值的见解。
786-O细胞系表现出清晰的细胞形态,是肾癌最常见的典型形式,其特征是特定的遗传改变,包括von Hippel-Lindau (VHL)肿瘤抑制基因的缺失。这一遗传特征是重要的,因为它通过影响缺氧诱导途径在许多透明细胞肾癌的发病机制中起着至关重要的作用,而缺氧诱导途径是细胞对低氧条件反应的核心。
该细胞对于研究肿瘤生长和存活的分子机制特别有用,包括与血管生成、代谢和细胞周期调节相关的途径。由于VHL缺乏,786-O细胞是研究缺氧影响和测试针对缺氧相关途径的药物的良好模型。除了在基础癌症研究中的应用,786-O细胞也被用于临床前研究,以评估新的治疗药物的疗效,特别是那些针对由缺氧诱导因子(hfs)过度表达驱动的血管生成过程的药物。这包括抑制HIF途径、酪氨酸激酶抑制剂和免疫检查点抑制剂的治疗。
总之,786-O细胞为我们进一步了解肾细胞癌的分子基础和开发靶向治疗方法提供了一个强大的模型,可以改善患有这种具有挑战性疾病的患者的治疗结果。

种属

性别/年龄

男/58岁

组织

疾病

肾细胞腺癌

细胞类型

肿瘤细胞

形态学

上皮的

生长方式

贴壁

倍增时间

大约22.4~45小时

培养基和添加剂

RPMI-1640(中乔新舟 货号:ZQ-200)+10%胎牛血清(中乔新舟 货号:ZQ500-A+1%P/S(中乔新舟货号:CSP006

推荐完全培养基货号

ZM0338

生物安全等级

BSL-1

STR位点信息

Amelogenin: X,Y

CSF1PO: 10

D13S317: 8

D16S539: 12

D5S818: 9

D7S820: 11,12

TH01: 6,9.3

TPOX: 8,11

vWA: 15,17

培养条件

95%空气,5%二氧化碳;37℃

抗原表达/受体表达

 ***

基因表达

 ***

保藏机构

ATCC; CRL-1932 BCRC; 60243

供应限制

仅供科研使用

货号

ZQ0338

发货规格

活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一

发货形式

活细胞:常温运输;冻存管:干冰运输

储存温度

活细胞:培养箱;冻存管:液氮罐

产地

中国

供应限制

仅供科研使用


论文标题: Triple-serotype chimeric oncolytic adenovirus exerts multiple synergistic mechanisms against solid tumors
DOI: 10.1136/jitc-2022-004691
发表时间: 2022-05-01
期刊: Journal for ImmunoTherapy of Cancer
影响因子: 13.751
货号: ZQ0338
产品名称: 786-O cells
原文链接:https://jitc.bmj.com/content/10/5/e004691.abstract


论文标题: Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma
DOI: 10.20892/j.issn.2095-3941.2020.0186
发表时间: 2021-02-15
期刊: Cancer Biology & Medicine
影响因子: 4.248
货号: ZQ0338
产品名称: 786-O cell

原文链接: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877181/



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Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)



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