产品名称	T-47D人乳腺管癌细胞
货号	ZQ0377
产品介绍	T-47D分离自一位54岁乳房侵入性导管癌的女性患者胸水，已成为乳腺癌研究的重要资源。T-47D细胞在癌症研究领域是独一无二的，因为它们的激素表达谱，特别是携带17 β雌二醇、各种其他类固醇和降钙素的受体。此外，T47D细胞表达WNT7B癌基因。 值得注意的是，T47D细胞的黄体酮受体表达不受雌二醇的调节，尽管这种激素在细胞内含量丰富，使它们与MCF7细胞区别开来，MCF7细胞因其雌激素受体阳性而被广泛认可，并经常被用来探索雌激素在肿瘤增殖和治疗反应中的作用。 T47D细胞系的应用扩展到免疫缺陷小鼠的异种移植物的形成，这对药物测试、观察受体状态变化和研究血管生成有价值。此外，T-47D细胞系是癌症基因研究的资源，提供了对驱动乳腺癌的基因组和蛋白质组学景观的见解。通过促进对乳腺癌蛋白质组学和转录组学特征的更深入了解，t47d乳腺癌细胞系有助于鉴定新的乳腺癌细胞表型和开发靶向治疗。 T47D细胞在研究黄体酮等激素对乳腺癌的影响方面发挥了重要作用，为转录调节、耐药性和开发用于治疗测试的异种移植模型提供了见解。 注意事项： T-47D [T47D]细胞需100%密度传代。T-47D细胞消化后成小片状脱落，并用培养液吹散细胞成圆细胞后进行传代，一定要要消化完全，否则细胞容易聚团生长。
种属	人
性别/年龄	女/54岁
组织	乳腺；来源于转移部位:胸腔积液
疾病	导管癌
细胞类型	肿瘤细胞
形态学	上皮
生长方式	贴壁
倍增时间	大约32~59.7小时
培养基和添加剂	DMEM高糖（品牌：中乔新舟  货号：ZQ-100）+10%FBS（品牌：中乔新舟  货号：ZQ500-A）+1%P/S（中乔新舟  货号：CSP006）
推荐完全培养基货号	ZM0377
生物安全等级	BSL-1
STR位点信息	Amelogenin: X CSF1PO: 11,13 D13S317: 12 D16S539: 10 D5S818: 12 D7S820: 11 TH01: 6 TPOX: 11 vWA: 14
培养条件	95%空气，5%二氧化碳；37℃
抗原表达/受体表达	***
基因表达	***
保藏机构	ATCC; HTB-133 DSMZ; ACC-739 ECACC; 85102201
供应限制	仅供科研使用

货号	ZQ0377
发货规格	活细胞：T25培养瓶*1瓶或者1ml 冻存管*1支（细胞量约为5 x 10^5 cells/vial）二选一
发货形式	活细胞：常温运输；冻存管：干冰运输
储存温度	活细胞：培养箱；冻存管：液氮罐
产地	中国
供应限制	仅供科研使用

论文标题： Prognostic value of gamma-interferon-inducible lysosomal thiol reductase expression in female patients diagnosed with breast cancer
DOI： 10.1002/ijc.33843
发表时间： 2021-10-25
期刊： INTERNATIONAL JOURNAL OF CANCER
影响因子： 7.396
货号： ZQ0377
产品名称： T47D cells

原文链接： https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.33843

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