人尿道上皮细胞HUC

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人尿道上皮细胞

英文名：Human Urothelial Cells
货号：4320
价格：￥15084.00

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人尿道上皮细胞说明：

人尿道上皮细胞排列在膀胱表面，它是由高可塑性和具有多种功能特殊类型的细胞组成。它们是膀胱防御系统的第一层，做为与病原体的接触面，它们具有多种防御机制来阻止病原体粘着，保持泌尿器溶解物的不渗透性。膀胱上皮细胞表达雌激素α、β受体，上皮生长因子受体和纤维母细胞生长因子受体，在损伤和感染时，这些受体对膀胱上皮细胞起着重要作用。它们还能释放许多细胞因子、免疫系统介质，这些新被认知的具有免疫调节潜在能力的尿道上皮细胞保证了最近两项发展的进一步研究：1)在实验室中培养正常膀胱上皮细胞的能力，2)免疫调节信号系统如何通过信号转导使尿道上皮细胞产生生物学功能。

人尿道上皮细胞(HUC)提取于人膀胱组织，原代冻存。每管含有细胞数>5×105 cells/ml，此细胞通过对Cytokeratin-18, -19 和Vimentin免疫荧光染色验证，经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。细胞可以达到15倍增

推荐培养基: 尿道上皮细胞培养基(UCM, Cat. No. 4321)

产品使用说明：仅供科研研究使用

货号	4320
产地	美国
缩写	HUC
规格	5 x 10^5 cells/vial
用途	科研
运输	干冰
保存	液氮

1.) Ting, K., Aitken, K.J., Penna, F., Samiei, A.N., Sidler, M., Jiang, J.X., Ibrahim, F., Tolg, C., Delgado-Olguin, P., Rosenblum, N. & Bagli, D.J. (2016) Uropathogenic E.coli (UPEC) Infection Induces Proliferation through Enhancer of Zeste Homologue 2 (EZH2) PLoS One. volume 11

2.) Tylden, G.D., Hirsch, H.H. & Rinaldo, C.H. (2015) Brincidofovir (CMX001) Inhibits BK Polyomavirus Replication in Primary Human Urothelial Cells Antimicrob Agents Chemother. 59

3.) Steins, A., Dik, P., M�ller, W.H., Vervoort, S.J., Reimers, K., Kuhbier, J.W., Vogt, P.M., van Apeldoorn, A.A., Coffer, P.J. & Schepers, K. (2015) In Vitro Evaluation of Spider Silk Meshes as a Potential Biomaterial for Bladder Reconstruction PLoS One. 10

4.) Li, J., Zhou, J., Zhang, D., Song, Y., She, J. & Bai, C. (2015) Bone marrow-derived mesenchymal stem cells enhance autophagy via PI3K/AKT signalling to reduce the severity of ischaemia/reperfusion-induced lung injury J Cell Mol Med. 19

5.) Li, C.F., Wu, W.J., Wu, W.R., Liao, Y.J., Chen, L.R., Huang, C.N., Li, C.C., Li, W.M., Huang, H.Y., Chen, Y.L., Liang, S.S., Chow, N.H. & Shiue, Y.L. (2015) The cAMP responsive element binding protein 1 transactivates epithelial membrane protein 2, a potential tumor suppressor in the urinary bladder urothelial carcinoma Oncotarget. 6

6.) Lee, M.S., Kim, J.H., Lee, J.S., Yun, S.J., Kim, W.J., Ahn, H. & Park, J. (2015) Prognostic Significance of CREB-Binding Protein and CD81 Expression in Primary High Grade Non-Muscle Invasive Bladder Cancer: Identification of Novel Biomarkers for Bladder Cancer Using Antibody Microarray PLoS One. 10

7.) Lu C, Lin M, Chen S, Shen C, Chen L, Hsieh H, Chan MWY, Hsu C. (2013) "The investigation of a traditional Chinese medicine, Guizhi Fuling Wan (GFW) as an intravesical therapeutic agent for urothelial carcinoma of the bladder." BMC Complement Altern Med. 13: 44.

8.) Marentette JO, Hauser PJ, Hurst RE, Klumpp DJ, Rickard A, McHowat J. (2013) "Tryptase activation of immortalized human urothelial cell mitogen-activated protein kinase." PLoS One. 8: e69948.

9.) Noguchi S, Yamada N, Kumazaki M, Yasui Y, Iwasaki J, Naito S, Akao Y. (2013) "socs7, a target gene of microRNA-145, regulates interferon-? induction through STAT3 nuclear translocation in bladder cancer cells." Cell Death Dis. 4: e482.

10.) Lee WY, Savage JR, Zhang J, Jia W, Oottamasathien S, Prestwich GD. (2013) "Prevention of Anti-microbial Peptide LL-37-Induced Apoptosis and ATP Release in the Urinary Bladder by a Modified Glycosaminoglycan." PloS one. 8: e77854.

11.) Tsang M, Chun YW, Im YM, Khang D, Webster TJ. (2011) "Effects of increasing carbon nanofiber density in polyurethane composites for inhibiting bladder cancer cell functions." Tissue Eng Part A. 17: 1879-89.

12.) Bhattacharya A, Tang L, Li Y, Geng F, Paonessa JD, Chen SC, Wong MK, Zhang Y. (2010) "Inhibition of bladder cancer development by allyl isothiocyanate."Carcinogenesis. 31: 281-6.

13.) Koizumi T, Nakatsuji H, Fukawa T, Avirmed S, Fukumori T, Takahashi M, Kanayama H. (2010) "The role of actinin-4 in bladder cancer invasion." Urology. 75: 357-64.

14.) Stone R 2nd, Sabichi AL, Gill J, Lee IL, Adegboyega P, Dai MS, Loganantharaj R, Trutschl M, Cvek U, Clifford JL. (2010) "Identification of genes correlated with early-stage bladder cancer progression." Cancer Prev Res (Phila). 3: 776-86.

15.) Chun YW, Khang D, Haberstroh KM, Webster TJ. (2009) "The role of polymer nanosurface roughness and submicron pores in improving bladder urothelial cell density and inhibiting calcium oxalate stone formation." Nanotechnology. 20: 085104.

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