产品名称 |
MM.1S人IgA-骨髓瘤细胞 |
货号 |
ZQ0485 |
产品介绍 |
MM.1S是一种人IgA-骨髓瘤细胞系,最初是从患有免疫球蛋白Aλ骨髓瘤的42岁黑人女性患者的外周血中分离的B淋巴母细胞建立的,这些细胞具有淋巴母细胞样的形态,并且既可以悬浮生长也可以轻微贴壁。可用于研究多发性骨髓瘤的疾病进展、药物治疗反应以及耐药性机制。对地塞米松敏感。
注意事项: |
种属 |
人 |
性别/年龄 |
女/42岁 |
组织 |
外周血 |
疾病 |
免疫球蛋白Aλ骨髓瘤 |
细胞类型 |
B淋巴细胞 |
形态学 |
淋巴母细胞 |
生长方式 |
半悬浮 |
倍增时间 |
大约72~80小时 |
培养基和添加剂 |
RPMI-1640(中乔新舟 货号:ZQ-200)+10%胎牛血清(中乔新舟 货号:ZQ0500)+1%双抗(中乔新舟 货号:CSP006)+1% Sodium Pyruvate 100 mM Solution(中乔新舟 货号:CSP003) +1%L-alanyl-L-glutamine(中乔新舟 货号:CSP004) |
推荐完全培养基货号 |
|
生物安全等级 |
BSL-1 |
STR位点信息 |
Amelogenin: X
|
培养条件 |
95%空气,5%二氧化碳;37℃ |
抗原表达/受体表达 |
文献报道抗原表达CD25、CD38、CD52和CD59,糖皮质激素受体。 |
基因表达 |
*** |
保藏机构 |
ATCC; CRL-2974 |
供应限制 |
仅供科研使用 |
货号 |
ZQ0485 |
发货规格 |
活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一 |
发货形式 |
活细胞:常温运输;冻存管:干冰运输 |
储存温度 |
活细胞:培养箱;冻存管:液氮罐 |
产地 |
中国 |
供应限制 |
仅供科研使用 |
原文链接: https://www.frontiersin.org/articles/10.3389/fimmu.2020.01292/full
PubMed=12691914; DOI=10.1016/S0301-472X(03)00023-7
Greenstein S., Krett N.L., Kurosawa Y., Ma C.-G., Chauhan D., Hideshima T., Anderson K.C., Rosen S.T.
Characterization of the MM.1 human multiple myeloma (MM) cell lines: a model system to elucidate the characteristics, behavior, and signaling of steroid-sensitive and -resistant MM cells.
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Haematologica 91:1234-1240(2006)
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Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.
Cancer Cell 12:131-144(2007)
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A high-risk signature for patients with multiple myeloma established from the molecular classification of human myeloma cell lines.
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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)
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Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)
PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)
PubMed=25688540; DOI=10.1002/cyto.a.22643
Maiga S., Brosseau C., Descamps G., Dousset C., Gomez-Bougie P., Chiron D., Menoret E., Kervoelen C., Vie H., Cesbron A., Moreau-Aubry A., Amiot M., Pellat-Deceunynck C.
A simple flow cytometry-based barcode for routine authentication of multiple myeloma and mantle cell lymphoma cell lines.
Cytometry A 87:285-288(2015)
PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)
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TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
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A landscape of pharmacogenomic interactions in cancer.
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Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)
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Tessoulin B., Moreau-Aubry A., Descamps G., Gomez-Bougie P., Maiga S., Gaignard A., Chiron D., Menoret E., Le Gouill S., Moreau P., Amiot M., Pellat-Deceunynck C.
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An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
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Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
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产品名称 | 价格 | 指令 |
Y3-Ag 1.2.3大鼠骨髓瘤细胞(种属鉴定) | ¥1800.00 | 购物车 》 |
NCI-H929人骨髓瘤细胞株 (STR鉴定) | ¥1800.00 | 购物车 》 |
FO小鼠骨髓瘤细胞(种属鉴定) | ¥1350.00 | 购物车 》 |
P3/NSI/1-Ag4-1 [NS-1]小鼠骨髓瘤细胞(种属鉴定) | ¥1000.00 | 购物车 》 |
P3X63Ag8小鼠骨髓瘤细胞(种属鉴定) | ¥1000.00 | 购物车 》 |
P3X63Ag8.653小鼠骨髓瘤细胞(种属鉴定) | ¥1000.00 | 购物车 》 |
U266B1人骨髓瘤细胞 | ¥1500.00 | 购物车 》 |