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NB4人急性早幼粒白血病细胞 (STR鉴定)
英文名: NB4
货号:ZQ0553
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NB4人急性早幼粒白血病细胞 (STR鉴定)

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  • 产品说明
  • 产品规格
  • 参考文献
  • STR鉴定

产品名称

NB4人急性早幼粒白血病细胞

货号

ZQ0553

产品介绍

NB-4细胞是一种人类急性早幼粒细胞白血病(APL)细胞系,从急性早幼粒细胞白血病第二次复发患者的骨髓中建立。该细胞系的特点是存在t(15;17)染色体易位,导致PML-RARα融合基因,这是APL的标志。NB4细胞系是研究APL发病机制和视黄酸(ATRA)、三氧化二砷(ATO)等治疗剂诱导分化作用机制的关键模型。
作为早幼粒细胞白血病细胞系,NB-4细胞表现出异常的分化模式,这是APL的特征。这种异常提供了一个独特的窗口,了解白血病进展的细胞机制和治疗干预的潜力。NB-4细胞在暴露于某些化疗药物或视黄酸等分化诱导剂后发生凋亡或程序性细胞死亡的能力,使其成为研究白血病背景下细胞凋亡的宝贵工具。NB-4细胞系也显示出两系分化的潜力,突出了其在特定条件下沿多种造血谱系分化的能力。
总之,NB-4细胞系以其独特的特性和对视黄酸等分化诱导剂的反应性,继续成为研究人员深入研究早幼粒细胞白血病的复杂性和更广泛的肿瘤学领域的关键资源。

种属

性别/年龄

女性/23岁

组织

骨髓

疾病

急性早幼粒细胞白血病

生物安全等级

BSL-1

STR位点信息

Amelogenin: X

CSF1PO 11,12

D2S1338 20,25

D3S1358 15,17

D5S818 13

D7S820 10,13

D8S1179 10,14

D13S317 11,12

D16S539 9

D18S51 12,14

D19S433 15

D21S11 28,33.2

FGA 21,22

Penta D 10,13

Penta E 7,13

TH01 7,9.3

TPOX 8,11

vWA 16,19

细胞类型

肿瘤细胞

形态学

圆形细胞

生长方式

悬浮液(单细胞)

倍增时间

大约30~45小时

培养基和添加剂

RPMI-1640(中乔新舟 货号:ZQ-200+10%胎牛血清(中乔新舟 货号:ZQ500-A+1%P/S(中乔新舟  货号:CSP006

推荐完全培养基货号

ZM0553

基因表达

 ***

保藏机构

CLS; 300299;DSMZ; ACC-207

供应限制

仅供科研使用


货号

ZQ0553

发货规格

活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一

发货形式

活细胞:常温运输;冻存管:干冰运输

储存温度

活细胞:培养箱;冻存管:液氮罐

产地

中国

供应限制

仅供科研使用

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