产品名称 |
NCI-H3122人非小细胞肺癌细胞 |
货号 |
ZQ0754 |
产品介绍 |
NCI-H3122细胞是一种来源于一名54岁白人男性的肺腺癌组织非小细胞肺癌(NSCLC)细胞株,由Modi等人在临床组织中分离纯化。NCI-H3122细胞的倍增时间约为48.5小时,呈现贴壁生长特性。它表达EML4-ALK融合基因,这使得它成为研究非小细胞肺癌治疗新靶点EML4-ALK的合适材料。
NCI-H3122细胞在长期接触克唑替尼后会逐渐产生耐药性,其IC50值显著提高,显示出对药物的耐受性增加。该细胞系在分子水平上表现出与非小细胞肺癌相关的基因表达特征。具体的基因突变和表达谱可能因研究而异,但通常涉及EGFR、ALK等重要的肿瘤相关基因。在药物处理后,NCI-H3122细胞的细胞周期可能会受到影响,表现出不同的增殖和凋亡特征。 |
种属 |
人 |
性别/年龄 |
男/54岁 |
组织 |
肺 |
疾病 |
非小细胞肺癌 |
细胞类型 |
肿瘤细胞 |
形态学 |
上皮样 |
生长方式 |
贴壁 |
倍增时间 |
大约48.5 hours (PubMed=29681454) |
培养基和添加剂 |
RPMI-1640(品牌:中乔新舟 货号:ZQ-200)+10%胎牛血清(中乔新舟 货号:ZQ500-A)+1%P/S(中乔新舟 货号:CSP006) |
推荐完全培养基货号 |
|
生物安全等级 |
BSL-1 |
培养条件 |
95%空气,5%二氧化碳;37℃ |
STR位点信息 |
Amelogenin:X CSF1PO: 11,12 D5S818: 11,12 D7S820: 8,12 D8S1179:13,15 D13S317:10,12 D16S539:11,12 D18S51: 13,16 FGA:18,21 Penta D: 10,13 Penta E: 12 TH01:7,9.3 TPOX:10 vWA:16 |
抗原表达/受体表达 |
*** |
基因表达 |
*** |
保藏机构 |
CLS; 300484 NCI-DTP; NCI-H3122 |
供应限制 |
仅供科研使用 |
货号 |
ZQ0754 |
发货规格 |
活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一 |
发货形式 |
活细胞:常温运输;冻存管:干冰运输 |
储存温度 |
活细胞:培养箱;冻存管:液氮罐 |
产地 |
中国 |
供应限制 |
仅供科研使用 |
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