产品名称 |
SUIT-2人胰腺癌细胞 |
货号 |
ZQ1009 |
产品介绍 |
SUIT-2细胞系是从一位73岁男性患者的肝转移胰腺癌组织中建立的,这位患者患有胰腺导管癌。该细胞系中发现了c-Ki-ras突变和p53抑癌基因的改变。SUIT-2细胞系被广泛用于癌症研究,包括药物筛选、基因表达研究、细胞信号传导研究等。此外,该细胞系还可用于3D细胞培养研究。SUIT-2细胞系可用于研究胰腺癌的发病机制、药物敏感性以及抗癌药物的筛选。例如,研究组抑胚胎发育相关信号通路Sonic hedgehog (Shh)对SUIT-2细胞增殖和凋亡的影响,发现通过特异性阻断该信号通路,可以抑制胰腺癌细胞增殖,并促进细胞凋亡。 |
种属 |
人 |
性别/年龄 |
男/73岁 |
组织 |
胰腺 |
疾病 |
胰腺癌 |
细胞类型 |
肿瘤细胞 |
形态学 |
上皮的 |
生长方式 |
贴壁 |
倍增时间 |
~38.2 hours (PubMed=3102439); 29.1 hours (PubMed=1391733); 15.64 hours (JWGray panel) |
培养基和添加剂 |
MEM(含NEAA)培养基(中乔新舟 货号:ZQ-300)+10%胎牛血清(中乔新舟 货号:ZQ500-A)+1%P/S(中乔新舟 货号:CSP006) |
推荐完全培养基货号 |
|
生物安全等级 |
BSL-1 |
培养条件 |
95%空气,5%二氧化碳;37℃ |
STR位点信息 |
Amelogenin :X CSF1PO: 11,12 D3S1358: 16 D5S818: 11,12 D7S820: 9,11 D8S1179: 14,15 D13S317 :9,11 D16S539: 9 D18S51: 16 D21S11 :29,30 FGA :20,23 Penta D :11 Penta E: 10 TH01 :6 TPOX: 8,10 vWA :16,17 |
抗原表达/受体表达 |
*** |
基因表达 |
*** |
保藏机构 |
JCRB; JCRB1094 |
供应限制 |
仅供科研使用 |
货号 |
ZQ1009 |
发货规格 |
活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一 |
发货形式 |
活细胞:常温运输;冻存管:干冰运输 |
储存温度 |
活细胞:培养箱;冻存管:液氮罐 |
产地 |
中国 |
供应限制 |
仅供科研使用 |
PubMed=3102439; DOI=10.20772/cancersci1985.78.1_54
Iwamura T., Katsuki T., Ide K.
Establishment and characterization of a human pancreatic cancer cell line (SUIT-2) producing carcinoembryonic antigen and carbohydrate antigen 19-9.
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Iwamura T., Taniguchi S., Kitamura N., Yamanari H., Kojima A., Hidaka K., Setoguchi T., Katsuki T.
Correlation between CA19-9 production in vitro and histological grades of differentiation in vivo in clones isolated from a human pancreatic cancer cell line (SUIT-2).
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Alterations of the p53 tumor-suppressor gene and ki-ras oncogene in human pancreatic cancer-derived cell-lines with different metastatic potential.
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Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping.
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Taxotere resistance in SUIT. Taxotere resistance in pancreatic carcinoma cell line SUIT 2 and its sublines.
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A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)
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A comprehensive transcriptional portrait of human cancer cell lines.
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Differential effector engagement by oncogenic KRAS.
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An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
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Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)
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