产品名称 |
LP-1人多发性骨髓瘤细胞 |
货号 |
ZQ1010 |
产品介绍 |
LP-1 细胞系是一种成熟的人类多发性骨髓瘤细胞系,1986年从一位患有多发性骨髓瘤(LGG,EBV阴性)白血病转化的56岁女性患者的外周血中分离建系,其特征是 t(4;14)(p16;q32) 易位,导致成纤维细胞生长因子受体 3 (FGFR3) 表达失调。这种基因畸变是多发性骨髓瘤亚组的标志,与疾病的发病机制和进展有关。LP-1 细胞表达功能性 FGFR3,当其被激活时,可以参与 MAP 激酶信号通路,促进细胞增殖和存活。值得注意的是,LP-1 携带 FGFR3 基因中的非激活 F384L 突变,这使其有别于其他具有 FGFR3 激活突变的骨髓瘤细胞系。 |
种属 |
人 |
性别/年龄 |
女/56岁 |
组织 |
外周血 |
疾病 |
多发性骨髓瘤 |
细胞类型 |
肿瘤细胞 |
形态学 |
圆形单个细胞 |
生长方式 |
悬浮 |
倍增时间 |
50 hours (PubMed=2784066); 48 hours (PubMed=25984343); 35-80 hours (Note=Depending on cell density) (DSMZ=ACC-41) |
培养基和添加剂 |
IMDM基础培养基(中乔新舟 货号:ZQ-900)+10%胎牛血清(中乔新舟 货号:ZQ0500)+1%P/S(中乔新舟 货号:CSP006) |
推荐完全培养基货号 |
|
生物安全等级 |
BSL-1 |
培养条件 |
95%空气,5%二氧化碳;37℃ |
STR位点信息 |
Amelogenin: X CSF1PO :11,12 D2S1338 :18,26 D3S1358: 16,18 D5S818 :11 D7S820: 11,12 D8S1179 :13 (DSMZ=ACC-41) :13,15 (PubMed=25877200) D13S317: 12 D16S539: 11,12 D18S51: 18 D19S433 :14 D21S11 :30,31 FGA: 20,21 Penta D: 12 Penta E :10,11 TH01: 7,8 TPOX :11 vWA: 17 |
抗原表达/受体表达 |
*** |
基因表达 |
*** |
保藏机构 |
DSMZ; ACC-41 |
供应限制 |
仅供科研使用 |
货号 |
ZQ1010 |
发货规格 |
活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一 |
发货形式 |
活细胞:常温运输;冻存管:干冰运输 |
储存温度 |
活细胞:培养箱;冻存管:液氮罐 |
产地 |
中国 |
供应限制 |
仅供科研使用 |
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