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U-2OS(U2OS)人骨肉瘤细胞(STR鉴定)
英文名:U-2OS(U2OS)
货号:ZQ0121
价格:¥1200.00
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U-2OS(U2OS)人骨肉瘤细胞(STR鉴定)

¥1200.00
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U-2 OS [U2OS]人骨肉瘤细胞专用培养基

¥350.00 ¥500.00

配套完培,省时省力,单买细胞无优惠

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  • 产品说明
  • 产品规格
  • 参考文献
  • STR鉴定

产品名称

U-2OS(U2OS)人骨肉瘤细胞

货号

ZQ0121

产品介绍

 J. Ponten and E. 这株细胞(原名2T)源自15岁女孩的胫骨中等分化的肉瘤。 与WI-38共培养或CF检测SV40,RSV或腺病毒时未检测到病毒。 1972年发现支原体污染并去除。 

种属

性别/年龄

/15岁

组织

骨;骨肉瘤

疾病

骨肉瘤(NCIt:C9145) 

生物安全等级

BSL-1

STR位点信息

Amelogenin: X

CSF1PO: 13

D13S317: 13

D16S539: 11,12

D5S818: 11

D7S820: 11,12

TH01: 6,9.3

TPOX: 11,12

vWA: 14,18

细胞类型

肿瘤细胞 

形态学

上皮细胞

生长方式

贴壁生长

倍增时间

大约25~36小时 

培养基和添加剂

90%DMEM高糖(品牌:中乔新舟 货号:ZQ-100)+10%FBS(品牌:中乔新舟 货号:ZQ0500+1%PS(中乔新舟  货号:CSP006)

推荐完全培养基货号

ZM0121

培养条件

37℃

抗原表达/受体表达

 

基因表达

 

保藏机构

ATCC、ECACC、DSMZ、

供应限制

仅供科研使用

货号

ZQ0121

发货规格

活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一

发货形式

活细胞:常温运输;冻存管:干冰运输

储存温度

活细胞:培养箱;冻存管:液氮罐

产地

中国

供应限制

仅供科研使用

1、论文标题: Combining autophagy-inducing peptides and brefeldin A delivered by perinuclear-localized mesoporous silica nanoparticles: a manipulation strategy for ER-phagy
DOI: 10.1039/C8NR00872H
发表时间: 2018-04-11
期刊: Nanoscale
影响因子: 7.233
货号: ZQ0121
产品名称: U2OS cells
原文链接: https://pubs.rsc.org/en/content/articlehtml/2018/nr/c8nr00872h


2、论文标题: Activation of CXCL6/CXCR1/2 Axis Promotes the Growth and Metastasis of Osteosarcoma Cells in vitro and in vivo
DOI: 10.3389/fphar.2019.00307
发表时间: 2019-03-28
期刊: Frontiers in Pharmacology
影响因子: 5.811
货号: ZQ0121
产品名称: U2OS cell lines
原文链接: https://www.frontiersin.org/articles/10.3389/fphar.2019.00307/full


3、论文标题: ADAM10 promotes cell growth, migration, and invasion in osteosarcoma via regulating E-cadherin/β-catenin signaling pathway and is regulated by miR-122-5p
DOI: 10.1186/s12935-020-01174-2
发表时间: 2020-03-30
期刊: Cancer Cell International
影响因子: 5.722
货号: ZQ0121
产品名称: U-2OS cells
原文链接: https://cancerci.biomedcentral.com/articles/10.1186/s12935-020-01174-2


4、论文标题: NPR3, transcriptionally regulated by POU2F1, inhibits osteosarcoma cell growth through blocking the PI3K/AKT pathway
DOI: 10.1016/j.cellsig.2021.110074
发表时间: 2021-07-03
期刊: CELLULAR SIGNALLING
影响因子: 4.315
货号: ZQ0121
产品名称: U2OS cells
原文链接: https://www.sciencedirect.com/science/article/pii/S0898656821001637


5、论文标题: Mxd1 mediates hypoxia‐induced cisplatin resistance in osteosarcoma cells by repression of the PTEN tumor suppressor gene
DOI: 10.1002/mc.22676
发表时间: 2017-06-15
期刊: MOLECULAR CARCINOGENESIS
影响因子: 4.185
货号: ZQ0121
产品名称: U-2OS cells
原文链接: https://onlinelibrary.wiley.com/doi/abs/10.1002/mc.22676


6、论文标题: Antitumor Effect of miR-1294/Pyruvate Kinase M2 Signaling Cascade in Osteosarcoma Cells
DOI: 10.2147/OTT.S232718
发表时间: 2020-02-21
期刊: OncoTargets and Therapy
影响因子: 4.147
货号: ZQ0121
产品名称: U2OS cells
原文链接: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041606/


7、论文标题: Salidroside suppresses the growth and invasion of human osteosarcoma cell lines MG63 and U2OS in vitro by inhibiting the JAK2/STAT3 signaling pathway
DOI: 10.3892/ijo.2019.4781
发表时间: 2019-06-01
期刊: INTERNATIONAL JOURNAL OF ONCOLOGY
影响因子: 3.571
货号: ZQ0121
产品名称: U2OS cells
原文链接: https://www.spandidos-publications.com/10.3892/ijo.2019.4781?text=fulltext


8、论文标题: miR-328-3p mediates the anti-tumor effect in osteosarcoma via directly targeting MMP-16
DOI: 10.1186/s12935-019-0829-7
发表时间: 2019-04-23
期刊: Cancer Cell International
影响因子: 3.439
货号: ZQ0121
产品名称: U2OS cells
原文链接: https://cancerci.biomedcentral.com/articles/10.1186/s12935-019-0829-7


9、论文标题: Circular RNA circVRK1 suppresses the proliferation, migration and invasion of osteosarcoma cells by regulating zinc finger protein ZNF652 expression via microRNA miR-337-3p
DOI: 10.1080/21655979.2021.1965695
发表时间: 2021-08-23
期刊: Bioengineered
影响因子: 3.269
货号: ZQ0121
产品名称: U-2OS cells
原文链接: https://www.tandfonline.com/doi/abs/10.1080/21655979.2021.1965695


10、论文标题: Piperlongumine induces apoptosis and G2/M phase arrest in human osteosarcoma cells by regulating ROS/PI3K/Akt pathway
DOI: 10.1016/j.tiv.2020.104775
发表时间: 2020-01-24
期刊: TOXICOLOGY IN VITRO
影响因子: 2.959
货号: ZQ0121
产品名称: U2OS cells
原文链接: https://www.sciencedirect.com/science/article/pii/S0887233319307799


11、论文标题: P16 promotes the growth and mobility potential of breast cancer both in vitro and in vivo: the key role of the activation of IL-6/JAK2/STAT3 signaling
DOI: 10.1007/s11010-018-3281-4
发表时间: 2018-01-31
期刊: MOLECULAR AND CELLULAR BIOCHEMISTRY
影响因子: 2.561
货号: ZQ0121
产品名称: U-2OS cells
原文链接: https://link.springer.com/article/10.1007/s11010-018-3281-4


12、论文标题: Effect of lncRNA ANRIL knockdown on proliferation and cisplatin chemoresistance of osteosarcoma cells in vitro
DOI: 10.1016/j.prp.2019.01.042
发表时间: 2019-01-30
期刊: PATHOLOGY RESEARCH AND PRACTICE
影响因子: 1.794
货号: ZQ0121
产品名称: U2-OS cells
原文链接: https://www.sciencedirect.com/science/article/pii/S0344033818316558


13、论文标题: MicroRNA‑208a‑3p promotes osteosarcoma progression via targeting PTEN
DOI: 10.3892/etm.2020.9385
发表时间: 2020-10-23
期刊: Experimental and Therapeutic Medicine
影响因子: 1.785
货号: ZQ0121
产品名称: U2OS cells
原文链接: https://www.spandidos-publications.com/10.3892/etm.2020.9385


14、论文标题: Knockdown of microRNA-203 reduces cisplatin chemo-sensitivity to osteosarcoma cell lines MG63 and U2OS in vitro by targeting RUNX2
DOI: 10.1080/1120009X.2021.1899441
发表时间: 2021-03-25
期刊: JOURNAL OF CHEMOTHERAPY
影响因子: 1.714
货号: ZQ0121
产品名称: U2OS cells
原文链接: https://www.tandfonline.com/doi/abs/10.1080/1120009X.2021.1899441


15、论文标题: MicroRNA-506-3p initiates mesenchymal-to-epithelial transition and suppresses autophagy in osteosarcoma cells by directly targeting SPHK1
DOI: 10.1080/09168451.2019.1569496
发表时间: 2019-01-23
期刊: BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
影响因子: 1.297
货号: ZQ0121
产品名称: U-2OS cells

原文链接: https://www.tandfonline.com/doi/abs/10.1080/09168451.2019.1569496


16、PubMed=23649806; DOI=10.1083/jcb.201210031

Kleiblova P., Shaltiel I.A., Benada J., Sevcik J., Pechackova S., Pohlreich P., Voest E.E., Dundr P., Bartek J., Kleibl Z., Medema R.H., Macurek L.
Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint.
J. Cell Biol. 201:511-521(2013)


17、PubMed=24136885; DOI=10.1002/pbc.24801
Guma S.R., Lee D.A., Yu L., Gordon N., Hughes D., Stewart J., Wang W.-L., Kleinerman E.S.
Natural killer cell therapy and aerosol interleukin-2 for the treatment of osteosarcoma lung metastasis.
Pediatr. Blood Cancer 61:618-626(2014)


18、PubMed=24618588; DOI=10.1371/journal.pone.0091433
Chernobrovkin A.L., Zubarev R.A.
Detection of viral proteins in human cells lines by xeno-proteomics: elimination of the last valid excuse for not testing every cellular proteome dataset for viral proteins.
PLoS ONE 9:E91433-E91433(2014)


19、PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)


20、PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)


21、PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)


22、PubMed=25894527; DOI=10.1371/journal.pone.0121314
Bausch-Fluck D., Hofmann A., Bock T., Frei A.P., Cerciello F., Jacobs A., Moest H., Omasits U., Gundry R.L., Yoon C., Schiess R., Schmidt A., Mirkowska P., Hartlova A.S., Van Eyk J.E., Bourquin J.-P., Aebersold R., Boheler K.R., Zandstra P.W., Wollscheid B.
A mass spectrometric-derived cell surface protein atlas.
PLoS ONE 10:E0121314-E0121314(2015)


23、PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074
Teicher B.A., Polley E.C., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J.
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)


24、PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)


25、PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)


26、PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)


27、PubMed=29853780; DOI=10.1155/2018/3082526
Salawu A., Wright K., Al-Kathiri A., Wyld L., Reed M.W.R., Sisley K.
Sister chromatid exchange and genomic instability in soft tissue sarcomas: potential implications for response to DNA-damaging treatments.
Sarcoma 2018:3082526.1-3082526.8(2018)


28、PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)


29、PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)


30、PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)


31、PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)



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