产品名称 |
SNU-5人胃癌细胞 |
货号 |
ZQ1044 |
产品介绍 |
SNU-5是一种人胃癌细胞系,最初是从一位低分化胃癌患者的转移性腹水中分离建立的。这种细胞系在癌症研究中被广泛使用,尤其是在胃癌的生物学特性研究、药物筛选和病理机制研究方面。SNU-5 系由 J. Park 及其同事于 1987 年从一名低分化胃癌患者的腹水中衍生而来。该患者之前曾接受过化疗,包括5-氟尿嘧啶、阿霉素和丝裂霉素-C。源自转移部位、腹水。阳性。 |
种属 |
人 |
性别/年龄 |
女/33岁 |
组织 |
胃 |
疾病 |
胃癌 |
细胞类型 |
肿瘤细胞 |
形态学 |
多细胞聚集体 |
生长方式 |
悬浮 |
倍增时间 |
34 hours (PubMed=2158397; PubMed=29435981) |
培养基和添加剂 |
RPMI-1640(品牌:中乔新舟 货号:ZQ-200)+10%胎牛血清(中乔新舟 货号:ZQ0500)+1%P/S(中乔新舟 货号:CSP006) |
推荐完全培养基货号 |
|
生物安全等级 |
BSL-1 |
培养条件 |
95%空气,5%二氧化碳;37℃ |
STR位点信息 |
Amelogenin: X CSF1PO :12 D2S1338 :17 D3S1358 :16 D5S818 :10 D7S820 :8,12 D8S1179: 14,15 D13S317 :8 (KCLB=00005) :8,9 (ATCC=CRL-5973; Cosmic-CLP=908445; PubMed=25877200) D16S539 :13 D18S51: 13 D19S433 :13.2,15 D21S11: 29 FGA :21 Penta D: 9,13 Penta E :18,19 TH01 :9 TPOX :11 vWA: 15,16 |
抗原表达/受体表达 |
*** |
基因表达 |
*** |
保藏机构 |
ATCC; CRL-5973 BCRC; 60213 KCLB; 00005 |
供应限制 |
仅供科研使用 |
货号 |
ZQ1044 |
发货规格 |
活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一 |
发货形式 |
活细胞:常温运输;冻存管:干冰运输 |
储存温度 |
活细胞:培养箱;冻存管:液氮罐 |
产地 |
中国 |
供应限制 |
仅供科研使用 |
PubMed=2158397
Park J.-G., Frucht H., La Rocca R.V., Bliss D.P. Jr., Kurita Y., Chen T.-R., Henslee J.G., Trepel J.B., Jensen R.T., Johnson B.E., Bang Y.-J., Kim J.-P., Gazdar A.F.
Characteristics of cell lines established from human gastric carcinoma.
Cancer Res. 50:2773-2780(1990)
PubMed=1676761; DOI=10.1093/jnci/83.13.938
Kim J.-H., Takahashi T., Chiba I., Park J.-G., Birrer M.J., Roh J.K., De Lee H., Kim J.-P., Minna J.D., Gazdar A.F.
Occurrence of p53 gene abnormalities in gastric carcinoma tumors and cell lines.
J. Natl. Cancer Inst. 83:938-943(1991)
DOI=10.1016/B978-0-12-333530-2.50014-9
Sekiguchi M., Suzuki T.
Gastric tumor cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.287-316; Academic Press; New York (1994)
PubMed=8806092; DOI=10.1002/jcb.240630505
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NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. 63 Suppl. 24:32-91(1996)
PubMed=8806095; DOI=10.1002/jcb.240630508
Park J.-G., Gazdar A.F.
Biology of colorectal and gastric cancer cell lines.
J. Cell. Biochem. 63 Suppl. 24:131-141(1996)
PubMed=19956504; DOI=10.4143/crt.2005.37.1.1
Ku J.-L., Park J.-G.
Biology of SNU cell lines.
Cancer Res. Treat. 37:1-19(2005)
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Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)
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A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)
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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)
PubMed=24807215; DOI=10.1038/ncomms4830
Liu J.-F., McCleland M.L., Stawiski E.W., Gnad F., Mayba O., Haverty P.M., Durinck S., Chen Y.-J., Klijn C., Jhunjhunwala S., Lawrence M., Liu H.-B., Wan Y.-N., Chopra V.S., Yaylaoglu M.B., Yuan W.-L., Ha C., Gilbert H.N., Reeder J., Pau G., Stinson J., Stern H.M., Manning G., Wu T.D., Neve R.M., de Sauvage F.J., Modrusan Z., Seshagiri S., Firestein R., Zhang Z.-M.
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Nat. Commun. 5:3830.1-3830.8(2014)
PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)
PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)
PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)
PubMed=26589293; DOI=10.1186/s13073-015-0240-5
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A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)
PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
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PubMed=29435981; DOI=10.1002/ijc.31304
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Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor.
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An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)
PubMed=31068700; DOI=10.1038/s41586-019-1186-3
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Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)
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Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)