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LA-N-1人神经母细胞瘤细胞(STR鉴定)
英文名:LA-N-1
货号:ZQ1114
价格:¥8800.00
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LA-N-1人神经母细胞瘤细胞(STR鉴定)

¥8800.00
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细胞套餐惊爆价

¥9450
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  • 产品说明
  • 产品规格
  • 参考文献
  • STR鉴定

产品名称

LA-N-1人神经母细胞瘤细胞

货号

ZQ1114

产品介绍

LA-N-1是一种人神经母细胞瘤细胞系,最初由Seeger等人在1977年从一名2岁男性患者的骨髓中建立,该患者患有临床IV期神经母细胞瘤。这些细胞在裸鼠体内具有致瘤性,并且是一种能够产生儿茶酚胺的神经母细胞瘤细胞系。

种属

性别/年龄

男/2岁

组织

骨髓

疾病

神经母细胞瘤

细胞类型

肿瘤细胞

形态学

上皮样

生长方式

半贴壁半悬浮

倍增时间

大约48~100 小时

培养基和添加剂

RPMI-1640(品牌:中乔新舟 货号:ZQ-200+20%胎牛血清(中乔新舟  货号:ZQ500-A+1%P/S(中乔新舟  货号:CSP006

推荐完全培养基货号

ZM1114

生物安全等级

BSL-1

培养条件

95%空气,5%二氧化碳;37℃

STR位点信息

Amelogenin: X,Y

CSF1PO 12

D2S1338 16,21

D3S1358 16,16.2

D5S818 12

D7S820 10 (COG)

             :10,11 (DSMZ=ACC-655; ECACC=06041201; RCB=RCB0483)

D8S1179 13,14

D13S317 11,12

D16S539 9

D18S51 14

D19S433 13

D21S11 29,36

FGA 19,24

Penta D 9,13

Penta E 11,12

TH01 8,9.3

TPOX 8,11

vWA 16,19

抗原表达/受体表达

*** 

基因表达

*** 

保藏机构

DSMZ; ACC-655

供应限制

仅供科研使用


货号

ZQ1114

发货规格

活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一

发货形式

活细胞:常温运输;冻存管:干冰运输

储存温度

活细胞:培养箱;冻存管:液氮罐

产地

中国

供应限制

仅供科研使用

PubMed=856461
Seeger R.C., Rayner S.A., Banerjee A., Chung H., Laug W.E., Neustein H.B., Benedict W.F.
Morphology, growth, chromosomal pattern and fibrinolytic activity of two new human neuroblastoma cell lines.
Cancer Res. 37:1364-1371(1977)


PubMed=7037175
Reynolds C.P., Reynolds D.A., Frenkel E.P., Smith R.G.
Selective toxicity of 6-hydroxydopamine and ascorbate for human neuroblastoma in vitro: a model for clearing marrow prior to autologous transplant.
Cancer Res. 42:1331-1336(1982)


DOI=10.1016/B978-0-12-008304-6.50015-4
Biedler J.L., Meyers M.B., Spengler B.A.
Homogeneously staining regions and double minute chromosomes, prevalent cytogenetic abnormalities of human neuroblastoma cells.
(In) Advances in cellular neurobiology, Vol. 4; Fedoroff S., Hertz L. (eds.); pp.267-307; Academic Press; New York (1983)


PubMed=2535691

Ciccarone V.C., Spengler B.A., Meyers M.B., Biedler J.L., Ross R.A.
Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages.
Cancer Res. 49:219-225(1989)


DOI=10.1016/B978-0-12-333530-2.50006-X
Israel M.A., Thiele C.J.
Tumor cell lines of the peripheral nervous system.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York (1994)


PubMed=7838528
Cheng N.C., Van Roy N., Chan A., Beitsma M., Westerveld A., Speleman F., Versteeg R.
Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35-36 region, only one of which is associated with N-myc amplification.
Oncogene 10:291-297(1995)


DOI=10.1007/0-306-46872-7_2
Thiele C.J.
Neuroblastoma.
(In) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York (1999)


PubMed=15892104; DOI=10.1002/gcc.20198
Mosse Y.P., Greshock J., Margolin A.A., Naylor T., Cole K., Khazi D., Hii G., Winter C., Shahzad S., Asziz M.U., Biegel J.A., Weber B.L., Maris J.M.
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Genes Chromosomes Cancer 43:390-403(2005)


PubMed=16822308; DOI=10.1186/1471-2407-6-177
Dam V., Morgan B.T., Mazanek P., Hogarty M.D.
Mutations in PIK3CA are infrequent in neuroblastoma.
BMC Cancer 6:177.1-177.10(2006)


PubMed=18082704; DOI=10.1016/j.jpedsurg.2007.08.026
Komuro H., Saihara R., Shinya M., Takita J., Kaneko S., Kaneko M., Hayashi Y.
Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines.
J. Pediatr. Surg. 42:2040-2045(2007)


PubMed=18165268; DOI=10.2353/ajpath.2008.061263
Stock C., Bozsaky E., Watzinger F., Poetschger U., Orel L., Lion T., Kowalska A., Ambros P.F.
Genes proximal and distal to MYCN are highly expressed in human neuroblastoma as visualized by comparative expressed sequence hybridization.
Am. J. Pathol. 172:203-214(2008)


PubMed=18724359; DOI=10.1038/nature07261
Mosse Y.P., Laudenslager M., Longo L., Cole K.A., Wood A., Attiyeh E.F., Laquaglia M.J., Sennett R., Lynch J.E., Perri P., Laureys G., Speleman F., Kim C., Hou C.-P., Hakonarson H., Torkamani A., Schork N.J., Brodeur G.M., Tonini G.P., Rappaport E., Devoto M., Maris J.M.
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)


PubMed=18923523; DOI=10.1038/nature07398
Janoueix-Lerosey I., Lequin D., Brugieres L., Ribeiro A., de Pontual L., Combaret V., Raynal V., Puisieux A., Schleiermacher G., Pierron G., Valteau-Couanet D., Frebourg T., Michon J., Lyonnet S., Amiel J., Delattre O.
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma.
Nature 455:967-970(2008)


PubMed=18923524; DOI=10.1038/nature07399
Chen Y.-Y., Takita J., Choi Y.L., Kato M., Ohira M., Sanada M., Wang L.-L., Soda M., Kikuchi A., Igarashi T., Nakagawara A., Hayashi Y., Mano H., Ogawa S.
Oncogenic mutations of ALK kinase in neuroblastoma.
Nature 455:971-974(2008)


PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)


PubMed=20655465; DOI=10.1016/j.cell.2010.06.004
Holzel M., Huang S.-D., Koster J., Ora I., Lakeman A., Caron H.N., Nijkamp W., Xie J., Callens T., Asgharzadeh S., Seeger R.C., Messiaen L.M., Versteeg R., Bernards R.
NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.
Cell 142:218-229(2010)


PubMed=22213050; DOI=10.1002/ijc.27415
Gawecka J.E., Geerts D., Koster J., Caliva M.J., Sulzmaier F.J., Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Int. J. Cancer 131:1556-1568(2012)

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