产品名称
|
HCC1588 人肺鳞癌细胞
|
货号
|
ZQ1136
|
产品介绍
|
HCC1588是一种人肺鳞状细胞癌细胞系,源自一位63岁女性的肺鳞状细胞癌。HCC1588细胞系主要用于科学研究,特别是在肺癌的研究领域,包括药物筛选、病理机制研究以及作为3D细胞培养模型等。有助于科学家们更好地理解这种疾病的生物学特性和开发新的治疗方法。
例如:HCC1588细胞系在肺癌病理机制研究中也扮演了重要角色,主要体现在:在疾病模型建立、药物筛选和疗效评估、病理机制探索、肿瘤微环境研究、耐药性研究、肿瘤异质性研究等。为理解疾病的病理机制和开发新的治疗方法提供了重要的实验工具。
|
种属
|
人
|
性别/年龄
|
女/63岁
|
组织
|
肺
|
疾病
|
鳞状细胞癌
|
细胞类型
|
肿瘤细胞
|
形态学
|
上皮
|
生长方式
|
贴壁
|
培养基和添加剂
|
RPMI-1640(中乔新舟 货号:ZQ-200)+10%胎牛血清(中乔新舟 货号:ZQ500-A)+1%P/S(中乔新舟 货号:CSP006)
|
推荐完全培养基货号
|
ZM1136
|
生物安全等级
|
BSL-2
|
培养条件
|
95%空气,5%二氧化碳;37℃
|
STR位点信息
|
Amelogenin: X
CSF1PO: 13
D3S1358: 17
D5S818: 8
D7S820 :10,11
D8S1179 :14
D13S317 :10,11 (PubMed=25877200)
:11 (KCLB=71588)
D16S539: 10
D18S51: 15,20
D21S11: 27,28
FGA :22
Penta D: 12
Penta E :7,13
TH01: 7,9
TPOX: 8,12
vWA: 16,19
|
抗原表达/受体表达
|
***
|
基因表达
|
***
|
保藏机构
|
KCLB; 71588
|
供应限制
|
仅供科研使用
|
货号
|
ZQ1136
|
发货规格
|
活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一
|
发货形式
|
活细胞:常温运输;冻存管:干冰运输
|
储存温度
|
活细胞:培养箱;冻存管:液氮罐
|
产地
|
中国
|
供应限制
|
仅供科研使用
|
PubMed=10353731
Wistuba I.I., Bryant D., Behrens C., Milchgrub S., Virmani A.K., Ashfaq R., Minna J.D., Gazdar A.F.
Comparison of features of human lung cancer cell lines and their corresponding tumors.
Clin. Cancer Res. 5:991-1000(1999)
PubMed=24002593; DOI=10.1038/bjc.2013.452
Wu D., Pang Y., Wilkerson M.D., Wang D., Hammerman P.S., Liu J.S.
Gene-expression data integration to squamous cell lung cancer subtypes reveals drug sensitivity.
Br. J. Cancer 109:1599-1608(2013)
PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)
PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)
PubMed=29681454; DOI=10.1016/j.cell.2018.03.028
McMillan E.A., Ryu M.-J., Diep C.H., Mendiratta S., Clemenceau J.R., Vaden R.M., Kim J.-H., Motoyaji T., Covington K.R., Peyton M., Huffman K., Wu X.-F., Girard L., Sung Y., Chen P.-H., Mallipeddi P.L., Lee J.Y., Hanson J., Voruganti S., Yu Y., Park S., Sudderth J., DeSevo C., Muzny D.M., Doddapaneni H., Gazdar A.F., Gibbs R.A., Hwang T.H., Heymach J.V., Wistuba I.I., Coombes K.R., Williams N.S., Wheeler D.A., MacMillan J.B., DeBerardinis R.J., Roth M.G., Posner B.A., Minna J.D., Kim H.S., White M.A.
Chemistry-first approach for nomination of personalized treatment in lung cancer.
Cell 173:864-878.e29(2018)
PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)
PubMed=31803961; DOI=10.1002/jcb.29564
Mulshine J.L., Ujhazy P., Antman M., Burgess C.M., Kuzmin I.A., Bunn P.A. Jr., Johnson B.E., Roth J.A., Pass H.I., Ross S.M., Aldige C.R., Wistuba I.I., Minna J.D.
From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.
J. Cell. Biochem. 121:3986-3999(2020)