人肺动脉平滑肌细胞HPASMC

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人肺动脉平滑肌细胞

英文名：Human Pulmonary Artery Smooth Muscle Cells
货号：3110
价格：￥13464.00

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人肺动脉平滑肌细胞说明：

平滑肌细胞是多数重要动脉疾病的靶细胞。血管SMC的生长潜力是原发血管病发展中至关重要的异常因素。最新研究表明SMC表达的钙通道，其表面表达的ICAM-1和VCAM-1，均参与了血管壁的炎症反应，并与血管疾病的进展和稳定有关。慢性肺组织缺氧能造成血管重塑，肺动脉平滑肌增生，最终导致肺动脉高压。人血管平滑肌的体外培养可作为血管研究模型，为血管疾病的治疗和药理学研究提供信息，发挥重要作用。

人肺动脉平滑肌细胞(HPASMC)提取于人肺动脉组织，原代冻存。每管含有细胞数>5×105cells/ml，此细胞通过对alpha-SMA和Desmin免疫荧光染色验证，经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。细胞可以达到15倍增。

配套培养基: 平滑肌培养基(SMCM, Cat. No. 1101)

产品使用说明：仅供科研研究使用

货号	3110
产地	美国
缩写	HPASMC
规格	5x10^5cells/vial
用途	科研
运输	干冰
保存	液氮

1.) Zhang, S., Liu, B., Fan, Z., Wang, D., Liu, Y., Li, J., Wang, N., Liu, Y. & Zhang, B. (2016) Targeted inhibition of survivin with YM155 promotes apoptosis of hypoxic human pulmonary arterial smooth muscle cells via the upregulation of voltage-dependent K+ channels Mol Med Rep. 13

2.) Yuan, K., Orcholski, M.E., Panaroni, C., Shuffle, E.M., Huang, N.F., Jiang, X., Tian, W., Vladar, E.K., Wang, L., Nicolls, M.R., Wu, J.Y. & de Jesus Perez, V.A. (2015) Activation of the Wnt/Planar Cell Polarity Pathway Is Required for Pericyte Recruitment during Pulmonary Angiogenesis Am J Pathol. 185

3.) Wang HL, Peng LP, Chen WJ, Tang SH, Sun BZ, Wang CL, Huang R, Xu ZJ, Lei WF. (2014) 'HMGB1 enhances smooth muscle cell proliferation and migration in pulmonary artery remodeling.'

4.) Ibrahim YF, Wong CM, Pavlickova L, Liu L, Trasar L, Bansal G, Suzuki YJ. (2014) 'Mechanism of the Susceptibility of Remodeled Pulmonary Vessels to Drug?Induced Cell Killing.'

5.) Wang G, Liu X, Meng L, Liu S, Wang L, Li J, Cui C, Meng J, Hu S, Wei Y. (2014) 'Up-Regulated Lipocalin-2 in Pulmonary Hypertension Involving in Pulmonary Artery SMC Resistance to Apoptosis.'

6.) Ibrahim YF, Wong CM, Pavlickova L, Liu L, Trasar L, Bansal G, Suzuki YJ. (2014) "Mechanism of the Susceptibility of Remodeled Pulmonary Vessels to Drug?Induced Cell Killing." J Am Heart Assoc. 3: e000520.

7.) Wang G, Liu X, Meng L, Liu S, Wang L, Li J, Cui C, Meng J, Hu S, Wei Y. (2014) "Up-Regulated Lipocalin-2 in Pulmonary Hypertension Involving in Pulmonary Artery SMC Resistance to Apoptosis." Int j biol sci. 10: 798-806.

8.) Wang HL, Peng LP, Chen WJ, Tang SH, Sun BZ, Wang CL, Huang R, Xu ZJ, Lei WF. (2014) "HMGB1 enhances smooth muscle cell proliferation and migration in pulmonary artery remodeling." Int j clinexppathol. 7: 3836-44.

9.) Zha WJ, Qian Y, Shen Y, Du Q, Chen FF, Wu ZZ, Li X, Huang M. (2013) "Galangin Abrogates Ovalbumin-Induced Airway Inflammation via Negative Regulation of NF-?B."Evid Based Complement Alternat Med. 2013:767689.

10.) Wang G, Zhang Z, Xu Z, Yin H, Bai L, Ma Z, Decoster MA, Qian G, Wu G. (2010) "Activation of the sonic hedgehog signaling controls human pulmonary arterial smooth muscle cell proliferation in response to hypoxia." Biochim Biophys Acta. 1803: 1359-67.

11.) de Frutos S, Nitta CH, Caldwell E, Friedman J, Gonz?lez Bosc LV. (2009) "Regulation of soluble guanylyl cyclase-alpha1 expression in chronic hypoxia-induced pulmonary hypertension: role of NFATc3 and HuR." Am J Physiol Lung Cell Mol Physiol. 297: L475-86.

12.) de Jesus Perez VA, Alastalo TP, Wu JC, Axelrod JD, Cooke JP, Amieva M, Rabinovitch M. (2009) "Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways." J Cell Biol.184: 83-99.

13.) Wang Z, Yuan Z, Jin L. (2008) "Gene delivery into hepatocytes with the preS/liposome/DNA system." Biotechnol J. 3: 1286-95.

14.) Armbruster BN, Li X, Pausch MH, Herlitze S, Roth BL. (2007) "Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand." Proc Natl Acad Sci USA. 104: 5163-8.

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