产品名称 |
HAL-01人急性淋巴细胞白血病细胞 |
货号 |
ZQ0768 |
产品介绍 |
HAL-01是一种人急性淋巴细胞白血病细胞系,它是由一名17岁的女性急性淋巴细胞白血病(ALL-L2)患者的外周血中建立的,这个细胞系含有t(17;19)(q22;p13) TCF3-HLF (E2A-HLF)融合基因,这是一种与白血病相关的染色体易位。这种遗传特征在白血病研究中至关重要,因为它影响白血病细胞的行为,包括其生长、分化和对治疗的反应等方面。
HAL-01细胞系在免疫学上表现为CD3阴性,CD10阳性,CD19阳性,CD34阴性,CD38阳性,CD80阴性,CD138阳性,HLA-DR阳性,并且不表达表面免疫球蛋白。此外,HAL-01细胞系在细胞遗传学上表现为近二倍体核型,含有4%的多倍体。
HAL-01 细胞系中 TCF3-HLF 融合基因的存在使其成为肿瘤学研究的宝贵资源,特别是对于专注于白血病发生机制和白血病靶向治疗开发的研究。该基因编码的融合蛋白参与基因转录的调节,并与患者不良预后相关,强调了该细胞系在急性淋巴细胞白血病治疗开发和预后研究中的重要性。 |
种属 |
人 |
性别/年龄 |
女/17岁 |
组织 |
外周血 |
疾病 |
b急性淋巴细胞白血病 |
细胞类型 |
b细胞前体白血病 |
形态学 |
单圆细胞 |
生长方式 |
悬浮部分细胞稍有粘附 |
倍增时间 |
大约32~48小时 |
培养基和添加剂 |
RPMI-1640(品牌:中乔新舟 货号:ZQ-200)+10%胎牛血清(中乔新舟 货号:ZQ0500)+1%P/S(中乔新舟 货号:CSP006) |
推荐完全培养基货号 |
|
生物安全等级 |
BSL-1 |
STR位点信息 |
Amelogenin:X |
培养条件 |
95%空气,5%二氧化碳;37℃ |
抗原表达/受体表达 |
*** |
基因表达 |
*** |
保藏机构 |
DSMZ; ACC-610 RCB; RCB0540 |
供应限制 |
仅供科研使用 |
货号 |
ZQ0768 |
发货规格 |
活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一 |
发货形式 |
活细胞:常温运输;冻存管:干冰运输 |
储存温度 |
活细胞:培养箱;冻存管:液氮罐 |
产地 |
中国 |
供应限制 |
仅供科研使用 |
PubMed=2027299
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FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.
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PubMed=20575032; DOI=10.1002/ajh.21738
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A specific linkage between the incidence of TP53 mutations and type of chromosomal translocations in B-precursor acute lymphoblastic leukemia cell lines.
Am. J. Hematol. 85:535-537(2010)
货号 | 产品名称 | 规格 | 价格 | 指令 |