配套完培,省时省力,单买细胞无优惠
产品名称 |
NCI-H1299人非小细胞肺癌细胞 |
货号 |
ZQ0007 |
产品介绍 |
NCI-H1299 是一种人非小细胞肺癌(Non-Small Cell Lung Cancer, NSCLC)细胞系,是一种上皮样细胞,分离自一名43岁的白人男性癌症患者的肺腺癌组织,该患者以前接受过放射治疗。肺腺癌是非小细胞肺癌中最常见的一种类型,占所有肺癌病例的大约40%。是研究非小细胞肺癌的重要工具,为理解肺癌的分子机制、发展新的治疗策略以及进行临床前药物测试提供了有价值的模型。 |
种属 |
人 |
性别/年龄 |
男;43岁 |
组织 |
肺;来源于转移部位:淋巴结 |
疾病 |
癌;非小细胞肺癌 |
生物安全等级 |
BSL-1 |
STR位点信息 |
Amelogenin: X |
细胞类型 |
肿瘤细胞 , 贴附型 |
形态学 |
上皮样 |
生长方式 |
贴壁 |
倍增时间 |
大约22.5~30小时 |
培养基和添加剂 |
RPMI-1640(中乔新舟 货号:ZQ-200)+10%胎牛血清(货号:ZQ500-A)+1%P/S(货号:CSP006) |
推荐完全培养基货号 |
|
培养条件 |
95%空气,5%二氧化碳;37℃ |
抗原表达/受体表达 |
*** |
基因表达 |
These cells stain positive for keratin and vimentin but are negative for neurofilament triplet protein. neuromedin B,The cells have a homozygous partial deletion of the p53 protein, and lack expression of p53 protein. The cells produce neuromedin B. |
保藏机构 |
ATCC; CRL-5803 |
供应限制 |
仅供科研使用 |
货号 |
ZQ0007 |
发货规格 |
活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一 |
发货形式 |
活细胞:常温运输;冻存管:干冰运输 |
储存温度 |
活细胞:培养箱;冻存管:液氮罐 |
产地 |
中国 |
供应限制 |
仅供科研使用 |
1、论文标题: Triple-serotype chimeric oncolytic adenovirus exerts multiple synergistic mechanisms against solid tumors
DOI: 10.1136/jitc-2022-004691
发表时间: 2022-05-01
期刊: Journal for ImmunoTherapy of Cancer
影响因子: 13.751
货号: ZQ0007
产品名称: NCI-H1299 cells
原文链接: https://jitc.bmj.com/content/10/5/e004691.abstract
2、论文标题: Tartrate-Resistant Acid Phosphatase 5/ACP5 Interacts with p53 to Control the Expression of SMAD3 in Lung Adenocarcinoma
DOI: 10.1016/j.omto.2020.01.010
发表时间: 2020-02-08
期刊: Molecular Therapy-Oncolytics
影响因子: 7.2
货号: ZQ0007
产品名称: NCI-H1299 cells
原文链接: https://www.sciencedirect.com/science/article/pii/S2372770520300206
3、论文标题: NEDD4L-induced ubiquitination mediating UBE2T degradation inhibits progression of lung adenocarcinoma via PI3K-AKT signaling
DOI: 10.1186/s12935-021-02341-9
发表时间: 2021-11-27
期刊: Cancer Cell International
影响因子: 5.722
货号: ZQ0007
产品名称: H1299 cell
原文链接: https://cancerci.biomedcentral.com/articles/10.1186/s12935-021-02341-9
4、论文标题: LncRNA PCBP1-AS1 correlated with the functional states of cancer cells and inhibited lung adenocarcinoma metastasis by suppressing the EMT progression
DOI: 10.1093/carcin/bgab047
发表时间: 2021-07-16
期刊: CARCINOGENESIS
影响因子: 4.944
货号: ZQ0007
产品名称: H1299 cell
原文链接: https://academic.oup.com/carcin/advance-article-abstract/doi/10.1093/carcin/bgab047/6295508
5、论文标题: miR‐363‐3p inhibits migration, invasion, and epithelial–mesenchymal transition by targeting NEDD9 and SOX4 in non‐small‐cell lung cancer
DOI: 10.1002/jcp.29099
发表时间: 2019-07-22
期刊: JOURNAL OF CELLULAR PHYSIOLOGY
影响因子: 4.522
货号: ZQ0007
产品名称: NCI-H1299 cells
原文链接: https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.29099
6、论文标题: Liver kinase B1 suppresses growth of lung cancer cells through sonic hedgehog signaling pathway
DOI: 10.1002/cbin.10965
发表时间: 2018-05-29
期刊: CELL BIOLOGY INTERNATIONAL
影响因子: 3.612
货号: ZQ0007
产品名称: H1299 cells
原文链接: https://onlinelibrary.wiley.com/doi/abs/10.1002/cbin.10965
7、论文标题: High expression of 14‑3‑3ơ indicates poor prognosis and progression of lung adenocarcinoma
DOI: 10.3892/ol.2022.13323
发表时间: 2022-05-12
期刊: Oncology Letters
影响因子: 2.967
货号: ZQ0007
产品名称: NCI-H1299 cells
原文链接: https://www.spandidos-publications.com/10.3892/ol.2022.13323
8、论文标题: Correlations of the ZEB1 expression with the incidence and prognosis of non-small cell lung cancer.
DOI: 10.26355/eurrev_201902_17111
发表时间: 2019-02-01
期刊: European Review for Medical and Pharmacological Sciences
影响因子: 2.721
货号: ZQ0007
产品名称: NCI-H1299 cells
原文链接: https://europepmc.org/article/med/30840275?javascript_support=no
9、论文标题: MicroRNA‐198‐5p inhibits the migration and invasion of non‐small lung cancer cells by targeting fucosyltransferase 8
DOI: 10.1111/1440-1681.13154
发表时间: 2019-08-30
期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
影响因子: 2.336
货号: ZQ0007
产品名称: NCI-H1299 cells
原文链接: https://onlinelibrary.wiley.com/doi/abs/10.1111/1440-1681.13154
10、论文标题: Loading MicroRNA-376c in Extracellular Vesicles Inhibits Properties of Non-Small Cell Lung Cancer Cells by Targeting YTHDF1:
DOI: 10.1177/1533033820977525
发表时间: 2020-12-07
期刊: TECHNOLOGY IN CANCER RESEARCH & TREATMENT
影响因子: 2.074
货号: ZQ0007
产品名称: NCI-H1299 cells
原文链接: https://journals.sagepub.com/doi/abs/10.1177/1533033820977525
11、论文标题: Development of c‑MET‑specific chimeric antigen receptor‑engineered natural killer cells with cytotoxic effects on human liver cancer HepG2 cells
DOI: 10.3892/mmr.2019.10529
发表时间: 2019-07-25
期刊: Molecular Medicine Reports
影响因子: 1.851
货号: ZQ0007
产品名称: lung cancer cell line H1299
原文链接: https://www.spandidos-publications.com/10.3892/mmr.2019.10529
12、论文标题: Liver kinase B1 suppresses the metastasis and angiogenesis of lung cancer: involvement of the Shh signaling pathway
DOI: 10.4149/neo_2018_180820N630
发表时间: 2019-05-23
期刊: NEOPLASMA
影响因子: 1.771
货号: ZQ0007
产品名称: H1299 cells
原文链接: https://pubmed.ncbi.nlm.nih.gov/30784288/
PubMed=1311061
Mitsudomi T., Steinberg S.M., Nau M.M., Carbone D.P., D'Amico D., Bodner S.M., Oie H.K., Linnoila R.I., Mulshine J.L., Minna J.D., Gazdar A.F.
p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features.
Oncogene 7:171-180(1992)
PubMed=1563005
Giaccone G., Battey J., Gazdar A.F., Oie H.K., Draoui M., Moody T.W.
Neuromedin B is present in lung cancer cell lines.
Cancer Res. 52:2732s-2736s(1992)
PubMed=1565469
Bodner S.M., Minna J.D., Jensen S.M., D'Amico D., Carbone D.P., Mitsudomi T., Fedorko J., Buchhagen D.L., Nau M.M., Gazdar A.F., Linnoila R.I.
Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation.
Oncogene 7:743-749(1992)
PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. Suppl. 24:32-91(1996)
PubMed=11030152; DOI=10.1038/sj.onc.1203815
Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.
Oncogene 19:4632-4639(2000)
PubMed=12068308; DOI=10.1038/nature00766
Davies H.R., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)
PubMed=17332333; DOI=10.1158/0008-5472.CAN-06-3339
Okabe T., Okamoto I., Tamura K., Terashima M., Yoshida T., Satoh T., Takada M., Fukuoka M., Nakagawa K.
Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification.
Cancer Res. 67:2046-2053(2007)
PubMed=18083107; DOI=10.1016/j.cell.2007.11.025
Rikova K., Guo A.-L., Zeng Q.-F., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y.-R., Tan Z.-P., Stokes M.P., Sullivan L., Mitchell J., Wetzel R., MacNeill J., Ren J.-M., Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D.-Q., Zhou X.-M., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Cell 131:1190-1203(2007)
PubMed=19153074; DOI=10.1093/hmg/ddp034
Medina P.P., Castillo S.D., Blanco S., Sanz-Garcia M., Largo C., Alvarez S., Yokota J., Gonzalez-Neira A., Benitez J., Clevers H.C., Cigudosa J.C., Lazo P.A., Sanchez-Cespedes M.
The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer.
Hum. Mol. Genet. 18:1343-1352(2009)
PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846
Blanco R., Iwakawa R., Tang M.-Y., Kohno T., Angulo B., Pio R., Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
A gene-alteration profile of human lung cancer cell lines.
Hum. Mutat. 30:1199-1206(2009)
PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)
PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680
Iwakawa R., Kohno T., Enari M., Kiyono T., Yokota J.
Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma.
Cancer Sci. 101:1891-1896(2010)
PubMed=20679594; DOI=10.1093/jnci/djq279; PMCID=PMC2935474
Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.
Lung cancer cell lines as tools for biomedical discovery and research.
J. Natl. Cancer Inst. 102:1310-1321(2010)
PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)
PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112; PMCID=PMC3567922
Byers L.A., Wang J., Nilsson M.B., Fujimoto J., Saintigny P., Yordy J., Giri U., Peyton M., Fan Y.-H., Diao L.-X., Masrorpour F., Shen L., Liu W.-B., Duchemann B., Tumula P., Bhardwaj V., Welsh J., Weber S., Glisson B.S., Kalhor N., Wistuba I.I., Girard L., Lippman S.M., Mills G.B., Coombes K.R., Weinstein J.N., Minna J.D., Heymach J.V.
Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.
Cancer Discov. 2:798-811(2012)
PubMed=24335698; DOI=10.1093/neuonc/not202; PMCID=PMC3895385
An Q., Fillmore H.L., Vouri M., Pilkington G.J.
Brain tumor cell line authentication, an efficient alternative to capillary electrophoresis by using a microfluidics-based system.
Neuro-oncol. 16:265-273(2014)
PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)
货号 | 产品名称 | 规格 | 价格 | 指令 |
ZQ0003 | A549人非小细胞肺癌细胞(STR鉴定) | 5 x 10^5 cells/vial | ¥1400.00 | 放入购物车 》 |
ZQ0384 | NCI-H358人非小细胞肺癌细胞 (STR鉴定) | 5 x 10^5 cells/vial | ¥1350.00 | 放入购物车 》 |
ZQ0385 | NCI-H1650人非小细胞肺癌细胞 (STR鉴定) | 5 x 10^5 cells/vial | ¥1350.00 | 放入购物车 》 |
ZQ0386 | HCC827人非小细胞肺癌细胞 (STR鉴定)[套餐促销] | 5 x 10^5 cells/vial | ¥1350.00 | 放入购物车 》 |
ZQ505-K | 支原体检测试剂盒 | 1ml/100T | ¥800.00 | 放入购物车 》 |
ZQ506 | 支原体清除试剂盒 | 1ml | ¥600.00 | 放入购物车 》 |
A1001-1 | 国产转染试剂 | 1ml | ¥800.00 | 放入购物车 》 |
1 | 慢病毒介导基因沉默或过表达 | ¥询价 | 放入购物车 》 | |
5 | 荧光素酶标记 | ¥询价 | 放入购物车 》 | |
6 | 绿/红色荧光蛋白标记 | ¥询价 | 放入购物车 》 | |
7 | 细胞基因敲除 | ¥询价 | 放入购物车 》 | |
ZQ-200 | RPMI-1640基础培养基 | 500ml | ¥56.00 | 放入购物车 》 |
ZQ-201 | RPMI-1640完全培养基 | 500ml | ¥350.00 | 放入购物车 》 |
ZQ500-A | 优级胎牛血清 | 500ml | ¥2580(开学促销) | 放入购物车 》 |