产品名称	A375人恶性黑色素瘤细胞
货号	ZQ0042
产品介绍	A375是一种人恶性黑色素瘤细胞系，来源于一名罹患黑色素瘤的54岁女性的皮肤组织，是Giard DJ等人建立的一系列细胞株中的一株。这种细胞系在癌症研究中非常有用，尤其是在研究恶性黑色素瘤的生物学特性、药物反应和转移机制方面。广泛应用于恶性黑色素瘤的研究，包括药物筛选、基因表达分析、信号传导途径研究、免疫治疗研究等。该细胞在抗胸腺细胞球蛋白、血清处理的NIH Swiss小鼠中形成类似于恶性黑素瘤的快速增殖的皮下肿瘤。
种属	人
性别/年龄	女性/54岁
组织	皮肤
疾病	恶性黑色素瘤
生物安全等级	BSL -1
STR位点信息	Amelogenin: X D3S1358: 15,17 TH01: 8 D21S11: 29,30 D18S51: 12,17 Penta_E: 10,12 D5S818: 12 D13S317: 11,14 D16S539: 9 CSF1PO: 11,12 Penta_D: 9,15 vWA: 16,17 D8S1179: 11,14 TPOX: 8,10 FGA: 20,23 D19S433: 13,14.2 D2S1338: 16,24 D7S820: 9
细胞类型	肿瘤细胞
形态学	贴壁生长
生长方式	贴壁
倍增时间	大约26.9~32小时
培养基和添加剂	DMEM（高糖）基础培养基（中乔新舟 货号：ZQ-100）+10%FBS（品牌：中乔新舟 货号：ZQ500-A）+1%PS（货号：CSP006）+1% Sodium Pyruvate 100 mM Solution（中乔新舟  货号：CSP003）+1%L-alanyl-L-glutamine（中乔新舟   货号：CSP004）
推荐完全培养基货号	ZM0042
培养条件	95%空气，5%二氧化碳；37℃
抗原表达/受体表达	***
基因表达	***
保藏机构	ATCC; CRL-1619 BCRC; 60051 DSMZ; ACC-175 ECACC; 92110305
供应限制	仅供科研使用

货号	ZQ0042
发货规格	活细胞：T25培养瓶*1瓶或者1ml 冻存管*1支（细胞量约为5 x 10^5 cells/vial）二选一
发货形式	活细胞：常温运输；冻存管：干冰运输
储存温度	活细胞：培养箱；冻存管：液氮罐
产地	中国
供应限制	仅供科研使用

论文标题： mGPDH Deficiency leads to melanoma metastasis via induced NRF2
DOI： 10.1111/jcmm.16542
发表时间： 2021-05-03
期刊： JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
影响因子： 5.31
货号： ZQ0042
产品名称： A375 cells

原文链接： https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.16542

论文标题： Identification and validation of a ferroptosis-related gene signature for predicting survival in skin cutaneous melanoma
DOI： 10.1002/cam4.4706
发表时间： 2022-04-04
期刊： Cancer Medicine
影响因子： 4.452
货号： ZQ0042
产品名称： A375 cells
原文链接： https://onlinelibrary.wiley.com/doi/abs/10.1002/cam4.4706

论文标题： Karyopherin α 2 promotes proliferation, migration and invasion through activating NF-κB/p65 signaling pathways in melanoma cells
DOI： 10.1016/j.lfs.2020.117611
发表时间： 2020-04-01
期刊： LIFE SCIENCES
影响因子： 3.647
货号： ZQ0042
产品名称： A375 cells
原文链接： https://www.sciencedirect.com/science/article/pii/S0024320520303593

论文标题： A high affinity nanobody against endothelin receptor type B: a new approach to the treatment of melanoma
DOI： 10.1007/s11033-020-05313-w
发表时间： 2020-02-20
期刊： MOLECULAR BIOLOGY REPORTS
影响因子： 2.316
货号： ZQ0042
产品名称： Human melanoma cell line A375
原文链接： https://link.springer.com/article/10.1007/s11033-020-05313-w

论文标题： Triclosan induces ROS‑dependent cell death and autophagy in A375 melanoma cells
DOI： 10.3892/ol.2020.11934
发表时间： 2020-07-30
期刊： Oncology Letters
影响因子： 2.311
货号： ZQ0042
产品名称： A375 cells

原文链接： https://www.spandidos-publications.com/10.3892/ol.2020.11934

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Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
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Cell 180:387-402.e16(2020)

PubMed=35128241; DOI=10.1021/acsomega.1c05361; PMCID=PMC8811929
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Proteomic changes in the monolayer and spheroid melanoma cell models of acquired resistance to BRAF and MEK1/2 inhibitors.
ACS Omega 7:3293-3311(2022)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
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