产品名称	PANC-1人胰腺癌细胞
货号	ZQ0065
产品介绍	PANC-1是一种人类胰腺癌细胞系，最初是从一位56岁白人男性的胰腺头部肿瘤导管组织中分离得到的。由Lieber M等人分离并建系，该细胞具有上皮细胞形态。可用于癌症研究和3D细胞培养。该细胞染色体为超三倍体，约22%细胞有63条染色体，包括3个独特标记的染色体和1个小环状染色体，是一个合适的转染宿主。据报道，该细胞带有KRAS（Gly12Asp）和TP53（Arg273His）突变，用1 U/ml 左旋天冬酰胺酶(L-asparaginase)可抑制其生长。此外，该细胞可以在成纤维细胞和琼脂糖上快速生长，并在免疫缺陷型小鼠体内成瘤。PANC-1细胞系是胰腺癌研究中的一个重要工具，例如：药物敏感性研究、基因功能研究、癌症治疗策略、纳米医学研究、长非编码RNA (lncRNA) 研究、基因表达调控研究，为理解胰腺癌的生物学特性和开发新的治疗方法提供了重要的实验模型。 注意事项： (1)传代时细胞的接种密度应控制在 1万-4万 活细胞/平方厘米。 (2)选用优质胎牛血清配制培养液，或者选购我司细胞完培。
种属	人
性别/年龄	男/56岁
组织	胰腺/导管
疾病	胰腺导管腺癌（上皮样癌）
细胞类型	肿瘤细胞
形态学	上皮
生长方式	贴壁
倍增时间	大约21~52小时
培养基和添加剂	DMEM高糖(中乔新舟 货号：ZQ-100）+10%胎牛血清（中乔新舟  货号：ZQ0500）+1%P/S（中乔新舟 货号：CSP006）
推荐完全培养基货号	ZM0065
生物安全等级	BSL-1
STR位点信息	Amelogenin: X CSF1PO: 10,12 D13S317: 11 D16S539: 11 D5S818: 11,13 D7S820: 8,10 TH01: 7,8 TPOX: 8,11 vWA: 15 D3S1358: 17 D21S11: 28 D18S51: 12 Penta_E: 7,14 Penta_D: 14 D8S1179: 14,15 FGA: 21 D19S433: 11,16 D2S1338: 23,24
培养条件	95%空气，5%二氧化碳；37℃
抗原表达/受体表达	***
基因表达	***
保藏机构	ATCC; CRL-1469
供应限制	仅供科研使用

货号	ZQ0065
发货规格	活细胞：T25培养瓶*1瓶或者1ml 冻存管*1支（细胞量约为5 x 10^5 cells/vial）二选一
发货形式	活细胞：常温运输；冻存管：干冰运输
储存温度	活细胞：培养箱；冻存管：液氮罐
产地	中国
供应限制	仅供科研使用

1、论文标题： The Role of Long Noncoding RNA AL161431.1 in the Development and Progression of Pancreatic Cancer
DOI： 10.3389/fonc.2021.666313
发表时间： 2021-07-30
期刊： Frontiers in Oncology
影响因子： 6.244
货号： ZQ0065
产品名称： PANC-1 cells

原文链接： https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363261/

2、论文标题： Inhibition of LINC00994 represses malignant behaviors of pancreatic cancer cells: interacting with miR-765-3p/RUNX2 axis
DOI： 10.1080/15384047.2018.1564566
发表时间： 2019-02-11
期刊： CANCER BIOLOGY & THERAPY
影响因子： 4.742
货号： ZQ0065
产品名称： Panc-1 cell lines
原文链接： https://www.tandfonline.com/doi/abs/10.1080/15384047.2018.1564566

3、论文标题： NEAT1/miR-101-dependent Up-regulation of DNA-PKcs Enhances Malignant Behaviors of Pancreatic Ductal Adenocarcinoma Cells
DOI： 10.7150/jca.58824
发表时间： 2021-07-25
期刊： Journal of Cancer
影响因子： 4.207
货号： ZQ0065
产品名称： PANC-1 cells
原文链接： https://www.ncbi.nlm.nih.gov/pmc/articles/pmc8364653/

4、论文标题： Silencing of ATF2 inhibits growth of pancreatic cancer cells and enhances sensitivity to chemotherapy
DOI： 10.1002/cbin.10760
发表时间： 2017-04-04
期刊： CELL BIOLOGY INTERNATIONAL
影响因子： 3.612
货号： ZQ0065
产品名称： PANC-1 cells
原文链接： https://onlinelibrary.wiley.com/doi/abs/10.1002/cbin.10760

5、论文标题： The biological behavior of tRNA-derived fragment tRF-Leu-AAG in pancreatic cancer cells
DOI： 10.1080/21655979.2022.2064206
发表时间： 2022-04-20
期刊： Bioengineered
影响因子： 3.269
货号： ZQ0065
产品名称： PANC-1 cells
原文链接： https://www.tandfonline.com/doi/abs/10.1080/21655979.2022.2064206

6、论文标题： HOXB5 promotes proliferation, migration, and invasion of pancreatic cancer cell through the activation of the GSK3β/β-catenin pathway
DOI： 10.1097/CAD.0000000000000948
发表时间： 2020-09-01
期刊： ANTI-CANCER DRUGS
影响因子： 2.26
货号： ZQ0065
产品名称： PANC-1 cells

原文链接： https://journals.lww.com/anti-cancerdrugs/Fulltext/2020/09000/HOXB5_promotes_proliferation,_migration,_and.8.aspx?context=LatestArticles

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9、PubMed=26589293; DOI=10.1186/s13073-015-0240-5
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10、PubMed=27067801; DOI=10.1186/s12885-016-2297-y
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11、PubMed=27259358; DOI=10.1074/mcp.M116.058313
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12、PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
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13、PubMed=30156359; DOI=10.1111/cas.13783
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14、PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
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15、PubMed=31037374; DOI=10.1007/s00216-019-01814-1
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16、PubMed=31068700; DOI=10.1038/s41586-019-1186-3
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Nature 569:503-508(2019)

17、PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
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Cell 180:387-402.e16(2020)

18、PubMed=32058723; DOI=10.1021/acs.jproteome.9b00840
Tan Z.-J., Zhu J.-H., Stemmer P.M., Sun L.-L., Yang Z.-C., Schultz K., Gaffrey M.J., Cesnik A.J., Yi X.-P., Hao X.-H., Shortreed M.R., Shi T.-J., Lubman D.M.
Comprehensive detection of single amino acid variants and evaluation of their deleterious potential in a PANC-1 cell line.
J. Proteome Res. 19:1635-1646(2020)

19、PubMed=32782605; DOI=10.3892/ol.2020.11825
Takagi K., Imura J., Shimomura A., Noguchi A., Minamisaka T., Tanaka S., Nishida T., Hatta H., Nakajima T.
Establishment of highly invasive pancreatic cancer cell lines and the expression of IL-32.
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