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CFPAC-1人胰腺癌细胞(STR鉴定)

英文名:CFPAC-1
货号:ZQ0252
价格:¥1350.00
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CFPAC-1人胰腺癌细胞(STR鉴定)

¥1350.00
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CFPAC-1人胰腺癌细胞专用培养基

¥350.00 ¥500.00

配套完培,省时省力,单买细胞无优惠

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细胞套餐惊爆价

¥1700 ¥2100.00
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  • 产品说明
  • 产品规格
  • 参考文献
  • STR鉴定

产品名称

CFPAC-1人胰腺癌细胞

货号

ZQ0252

产品介绍

CFPAC-1是胰腺管腺癌细胞系,建自26岁男性囊性纤维变性(CF)的肝转移灶,患有囊性纤维化和导管腺癌肝转移,细胞系是一种具有显著生物学研究特征的超二倍体细胞系。它们的粘附生长特性和在裸鼠中的致瘤能力使它们成为体外癌症研究的实用模型。该细胞系的核型包括 73 条染色体的众数,其中有几次易位,重要的是,7 号染色体有两到三个拷贝,囊性纤维化基因就位于此处。


这些细胞表达癌症相关抗原和基因,如 CA19-9、癌胚抗原 (CEA)、胰腺癌胚抗原 (POA)、腺癌相关抗原 (ACAA) 和上皮角蛋白,为癌症生物学提供了见解。在囊性纤维化病理学方面,CFPAC-1 细胞表现出独特的离子转运活性。它们对 cAMP 激动剂、腺苷酸环化酶刺激剂或磷酸二酯酶抑制剂没有反应,但对钙离子载体有反应,氯离子流出增加。

CFPAC-1 细胞携带常见的囊性纤维化突变 - 三个核苷酸缺失,导致 CFTR 基因 508 位苯丙氨酸缺失。从形态上看,它们表现出上皮特征,具有顶端微绒毛、紧密连接和间隙连接,与研究癌症和囊性纤维化中的上皮组织相互作用有关。

种属

性别/年龄

男/25岁

组织

胰腺;来源于转移性肿瘤:肝脏

疾病

导管腺癌;囊性纤维化

细胞类型

肿瘤细胞

形态学

上皮细胞

生长方式

贴壁

倍增时间

大约32~45小时 

培养基和添加剂

IMDM(中乔新舟  货号:ZQ-900+10%胎牛血清(中乔新舟 货号:ZQ0500)+1%双抗(中乔新舟 货号:CSP006

推荐完全培养基货号

ZM0252

生物安全等级

BSL-1

STR位点信息

Amelogenin: X,Y

CSF1PO: 10
D13S317: 12
D16S539: 9,11
D5S818: 10,11
D7S820: 8,10
TH01: 8
TPOX: 8
vWA: 17
D3S1358: 16
D21S11: 30,31.2
D18S51: 12
Penta_E: 10,12
Penta_D: 11,13
D8S1179: 11,15
FGA: 21,22
D19S433: 13,15
D2S1338: 18,23

培养条件

95%空气,5%二氧化碳;37℃

抗原表达/受体表达

*** 

基因表达

*** 

保藏机构

ATCC; CRL-1918 ECACC; 91112501

供应限制

仅供科研使用

货号

ZQ0252

发货规格

活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一

发货形式

活细胞:常温运输;冻存管:干冰运输

储存温度

活细胞:培养箱;冻存管:液氮罐

产地

中国

供应限制

仅供科研使用


论文标题: HOXB5 promotes proliferation, migration, and invasion of pancreatic cancer cell through the activation of the GSK3β/β-catenin pathway
DOI: 10.1097/CAD.0000000000000948
发表时间: 2020-09-01
期刊: ANTI-CANCER DRUGS
影响因子: 2.26
货号: ZQ0252
产品名称: CFPAC-1 cells

原文链接: https://journals.lww.com/anti-cancerdrugs/Fulltext/2020/09000/HOXB5_promotes_proliferation,_migration,_and.8.aspx?context=LatestArticles



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