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U-937人组织细胞淋巴瘤细胞(STR鉴定)

英文名:U-937
货号:ZQ0087
价格:¥1350.00
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U-937人组织细胞淋巴瘤细胞(STR鉴定)

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U-937人组织细胞淋巴瘤细胞专用培养基

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  • 产品说明
  • 产品规格
  • 参考文献
  • STR鉴定

产品名称

U-937人组织细胞淋巴瘤细胞

货号

ZQ0087

产品介绍

U-937是一种人组织细胞淋巴瘤细胞系,最初由Sundstrom和Nilsson在1974年从一位37岁白人男性患者细胞淋巴瘤病人的胸腔积液中分离得到。这种细胞系具有单核细胞形态,能在悬浮状态下生长,并且可以通过特定的诱导剂如人混合淋巴细胞培养上清、佛波脂、维生素D3、γ干扰素、肿瘤坏死因子和维甲酸等诱导终末单核细胞分化。该细胞免疫球蛋白产物和EB病毒表达为阴性。该细胞表达federation of american scientists 美国科学家联合会抗原且对TNF和抗-Fas抗体敏感。
U-937细胞系在免疫学、肿瘤学、细胞生物学和药理学研究中有着广泛的应用。例如:免疫学研究中通常用于以下类型的实验:细胞分化研究、细胞信号传导、免疫调节、肿瘤免疫、细胞吞噬功能、细胞因子和趋化因子的研究、基因功能研究、药物筛选和毒性测试、炎症研究、巨噬细胞极化等。这些实验有助于理解单核细胞和巨噬细胞的生物学特性,以及它们在疾病状态下的作用机制。
该细胞免疫球蛋白产物和EB病毒表达为阴性。 该细胞表达Fas抗原且对TNF和抗-Fas抗体敏感。也可以作为基因转染的宿主细胞。

种属

性别/年龄

男/37岁

组织

胸膜/胸腔积液,淋巴细胞,髓样

疾病

组织细胞淋巴瘤

细胞类型

肿瘤细胞 

形态学

单核细胞

生长方式

悬浮

倍增时间

大约30~100小时 

培养基和添加剂

RPMI-1640(中乔新舟 货号:ZQ-200)+10%胎牛血清(中乔新舟 货号:ZQ0500)+1%双抗(中乔新舟   货号:CSP006

推荐完全培养基货号

ZM0087

生物安全等级

BSL-1

STR位点信息

Amelogenin: X

CSF1PO: 12
D13S317: 10,12
D16S539: 12
D5S818: 12
D7S820: 9,11
TH01: 6,9.3
TPOX: 8,11
vWA: 14,15
D3S1358: 16
D21S11: 27,29
D18S51: 13,14
Penta_E: 13
Penta_D: 12,13
D8S1179: 12,13
FGA: 22,25
D19S433: 14,16
D2S1338: 17,20

培养条件

95%空气,5%二氧化碳;37℃

抗原表达/受体表达

*** 

基因表达

*** 

保藏机构

ATCC; CRL-1593 ATCC; CRL-1593.2 DSMZ; ACC-5 ECACC; 85011440

供应限制

仅供科研使用

货号

ZQ0087

发货规格

活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一

发货形式

活细胞:常温运输;冻存管:干冰运输

储存温度

活细胞:培养箱;冻存管:液氮罐

产地

中国

供应限制

仅供科研使用


1、论文标题: MDM2 inhibition-mediated autophagy contributes to the pro-apoptotic effect of berberine in p53-null leukemic cells
DOI: 10.1016/j.lfs.2019.117228
发表时间: 2019-12-24
期刊: LIFE SCIENCES
影响因子: 3.448
货号: ZQ0087
产品名称: U937 cells

原文链接: https://www.sciencedirect.com/science/article/pii/S0024320519311567


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Leukemia 20:471-476(2006)


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Proteomic differentiation pattern in the U937 cell line.
Leuk. Res. 35:226-236(2011)


6、PubMed=21269460; DOI=10.1186/1752-0509-5-17
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7、PubMed=22460905; DOI=10.1038/nature11003
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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)


8、DOI=10.1016/j.actaastro.2013.06.007
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Severe disruption of the cytoskeleton and immunologically relevant surface molecules in a human macrophageal cell line in microgravity -- results of an in vitro experiment on board of the Shenzhou-8 space mission.
Acta Astronaut. 94:277-292(2013)


9、PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)


10、PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)


11、PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)


12、PubMed=29787063; DOI=10.1007/978-3-319-16104-4_14
Chanput W., Peters V., Wichers H.J.
THP-1 and U937 cells.
(In) The impact of food bioactives on health. In vitro and ex vivo models; Verhoeckx K., Cotter P., Lopez-Exposito I., Kleiveland C., Lea T., Mackie A., Requena T., Swiatecka D., Wichers H. (eds.); pp.147-159; Springer; Cham (2015)


13、PubMed=30285677; DOI=10.1186/s12885-018-4840-5
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)


14、PubMed=30629668; DOI=10.1371/journal.pone.0210404
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Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:E0210404-E0210404(2019)


15、PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
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An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
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16、PubMed=31068700; DOI=10.1038/s41586-019-1186-3
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Next-generation characterization of the Cancer Cell Line Encyclopedia.
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17、PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)


18、PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
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19、PubMed=33317567; DOI=10.1186/s13039-020-00517-y
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Detailed molecular cytogenetic characterisation of the myeloid cell line U937 reveals the fate of homologous chromosomes and shows that centromere capture is a feature of genome instability.
Mol. Cytogenet. 13:50.1-50.14(2020)


20、PubMed=34707142; DOI=10.1038/s41598-021-00623-w
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Divergent leukaemia subclones as cellular models for testing vulnerabilities associated with gains in chromosomes 7, 8 or 18.
Sci. Rep. 11:21145-21145(2021)


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