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B-CPAP人甲状腺癌细胞(STR鉴定)

英文名:B-CPAP
货号:ZQ0304
价格:¥1800.00
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推荐组合

B-CPAP人甲状腺癌细胞(STR鉴定)

¥1800.00
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B-CPAP人甲状腺癌细胞专用培养基

¥700.00

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细胞套餐惊爆价

¥2500
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  • 产品说明
  • 产品规格
  • 参考文献
  • STR鉴定

产品名称

B-CPAP人甲状腺癌细胞

货号

ZQ0304

产品介绍

B-CPAP 是一种人类乳头状甲状腺癌细胞系,于1992年从一名罹患转移性甲状腺乳头状癌的76岁女性的肿瘤组织中建立。该细胞系表现出上皮样形态,常用于研究甲状腺癌生物学,包括肿瘤发生和转移机制。B-CPAP 细胞因携带 BRAF V600E 突变而著名,这是一种与侵袭性甲状腺癌相关的常见基因变异,是评估 BRAF 抑制剂作为治疗剂的关键模型。

除了 BRAF 突变外,B-CPAP 细胞还表达甲状腺特异性标志物,如甲状腺球蛋白和促甲状腺激素受体,使其成为研究甲状腺功能和病理的宝贵模型。它们已广泛用于研究与甲状腺癌进展有关的信号通路,包括 MAPK/ERK 通路激活。这些细胞还用于药物耐药性和细胞凋亡研究,为甲状腺癌治疗失败的机制提供了见解。

种属

性别/年龄

女/76岁

组织

甲状腺

疾病

甲状腺癌

细胞类型

肿瘤细胞 

形态学

纺锤状或圆形细胞贴壁生长成单层细胞

生长方式

贴壁

倍增时间

大约30小时 

培养基和添加剂

RPMI-1640(中乔新舟 货号:ZQ-200)+10%胎牛血清(中乔新舟 货号:ZQ0500)+1%P/S(中乔新舟  货号:CSP006)+1%Non-essential Amino Acids, 100X (中乔新舟  货号:CSP008)+ +1% Sodium Pyruvate 100 mM Solution(中乔新舟  货号:CSP003)+1%L-alanyl-L-glutamine(中乔新舟   货号:CSP004

推荐完全培养基货号

ZM0304

生物安全等级

BSL-1

STR位点信息

Amelogenin: X;

CSF1PO: 13
D2S1338:18
D3S1358:16,17
D5S818: 10,11
D7S820: 10
D8S1179:12,13
D13S317:12
D16S539:11,12
D18S51: 13,17
D19S433:13.2,15 (PubMed=25877200)
             :14,15 (DSMZ=ACC-273)
D21S11: 30 (DSMZ=ACC-273)
           :30,31.2 (PubMed=18713817; PubMed=25877200; PubMed=30737244)
FGA:20,23
Penta D: 10,11
Penta E: 5,12 (DSMZ=ACC-273)
            :5,12,17 (PubMed=25877200)
TH01:6,9.3
TPOX:8,11
vWA:14,17

培养条件

95%空气,5%二氧化碳;37℃

抗原表达/受体表达

*** 

基因表达

*** 

保藏机构

DSMZ; ACC-273

供应限制

仅供科研使用


货号

ZQ0304

发货规格

活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一

发货形式

活细胞:常温运输;冻存管:干冰运输

储存温度

活细胞:培养箱;冻存管:液氮罐

产地

中国

供应限制

仅供科研使用


论文标题: Hypomethylated gene RAC3 induces cell proliferation and invasion by increasing FASN expression in endometrial cancer
DOI:10.1016/j.biocel.2022.106274. Epub 2022 Jul 30
发表时间: 2022-8-1
期刊: The International Journal of Biochemistry & Cell Biology
影响因子: 3.4
货号: ZQ0304
产品名称:  BCPAP cells
原文链接:https://www.sciencedirect.com/science/article/abs/pii/S1357272522001194?via%3Dihub


论文标题: Identification and Application of an Aptamer Targeting Papillary Thyroid Carcinoma Using Tissue-SELEX

DOI: 10.1021/acs.analchem.9b01000
发表时间: 2019-05-29
期刊: ANALYTICAL CHEMISTRY
影响因子: 6.35
货号: ZQ0304
产品名称: BCPAP cells

原文链接: https://pubs.acs.org/doi/abs/10.1021/acs.analchem.9b01000



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PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
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PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
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PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953
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