产品名称 |
B-CPAP人甲状腺癌细胞 |
货号 |
ZQ0304 |
产品介绍 |
B-CPAP 是一种人类乳头状甲状腺癌细胞系,于1992年从一名罹患转移性甲状腺乳头状癌的76岁女性的肿瘤组织中建立。该细胞系表现出上皮样形态,常用于研究甲状腺癌生物学,包括肿瘤发生和转移机制。B-CPAP 细胞因携带 BRAF V600E 突变而著名,这是一种与侵袭性甲状腺癌相关的常见基因变异,是评估 BRAF 抑制剂作为治疗剂的关键模型。 除了 BRAF 突变外,B-CPAP 细胞还表达甲状腺特异性标志物,如甲状腺球蛋白和促甲状腺激素受体,使其成为研究甲状腺功能和病理的宝贵模型。它们已广泛用于研究与甲状腺癌进展有关的信号通路,包括 MAPK/ERK 通路激活。这些细胞还用于药物耐药性和细胞凋亡研究,为甲状腺癌治疗失败的机制提供了见解。 |
种属 |
人 |
性别/年龄 |
女/76岁 |
组织 |
甲状腺 |
疾病 |
甲状腺癌 |
细胞类型 |
肿瘤细胞 |
形态学 |
纺锤状或圆形细胞贴壁生长成单层细胞 |
生长方式 |
贴壁 |
倍增时间 |
大约30小时 |
培养基和添加剂 |
RPMI-1640(中乔新舟 货号:ZQ-200)+10%胎牛血清(中乔新舟 货号:ZQ0500)+1%P/S(中乔新舟 货号:CSP006)+1%Non-essential Amino Acids, 100X (中乔新舟 货号:CSP008)+ +1% Sodium Pyruvate 100 mM Solution(中乔新舟 货号:CSP003)+1%L-alanyl-L-glutamine(中乔新舟 货号:CSP004) |
推荐完全培养基货号 |
|
生物安全等级 |
BSL-1 |
STR位点信息 |
Amelogenin: X;
CSF1PO: 13 |
培养条件 |
95%空气,5%二氧化碳;37℃ |
抗原表达/受体表达 |
*** |
基因表达 |
*** |
保藏机构 |
DSMZ; ACC-273 |
供应限制 |
仅供科研使用 |
货号 |
ZQ0304 |
发货规格 |
活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一 |
发货形式 |
活细胞:常温运输;冻存管:干冰运输 |
储存温度 |
活细胞:培养箱;冻存管:液氮罐 |
产地 |
中国 |
供应限制 |
仅供科研使用 |
论文标题: Hypomethylated gene RAC3 induces cell proliferation and invasion by increasing FASN expression in endometrial cancer
DOI:10.1016/j.biocel.2022.106274. Epub 2022 Jul 30
发表时间: 2022-8-1
期刊: The International Journal of Biochemistry & Cell Biology
影响因子: 3.4
货号: ZQ0304
产品名称: BCPAP cells
原文链接:https://www.sciencedirect.com/science/article/abs/pii/S1357272522001194?via%3Dihub
论文标题: Identification and Application of an Aptamer Targeting Papillary Thyroid Carcinoma Using Tissue-SELEX
DOI: 10.1021/acs.analchem.9b01000原文链接: https://pubs.acs.org/doi/abs/10.1021/acs.analchem.9b01000
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Description of a cell line established from a human thyroid papillary carcinoma and synthesizing human chorionic gonadotropin hormone.
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Description of a human papillary thyroid carcinoma cell line Morphologic study and expression of tumoral markers.
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Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to hepatocyte growth factor.
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Comprehensive conventional and molecular cytogenetic characterization of B-CPAP, a human papillary thyroid carcinoma-derived cell line.
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Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype.
Cancer Res. 67:8113-8120(2007)
PubMed=18713817; DOI=10.1210/jc.2008-1102
Schweppe R.E., Klopper J.P., Korch C.T., Pugazhenthi U., Benezra M., Knauf J.A., Fagin J.A., Marlow L.A., Copland J.A. III, Smallridge R.C., Haugen B.R.
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J. Clin. Endocrinol. Metab. 93:4331-4341(2008)
PubMed=19087340; DOI=10.1186/1471-2407-8-371
Ribeiro F.R., Meireles A.M., Rocha A.S., Teixeira M.R.
Conventional and molecular cytogenetics of human non-medullary thyroid carcinoma: characterization of eight cell line models and review of the literature on clinical samples.
BMC Cancer 8:371.1-371.11(2008)
PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)
PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)
PubMed=22087789; DOI=10.1186/1755-8166-4-26
Maric I., Viaggi S., Caria P., Frau D.V., Degan P., Vanni R.
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Mol. Cytogenet. 4:26.1-26.8(2011)
PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)
PubMed=23162534; DOI=10.3389/fendo.2012.00133
Saiselet M., Floor S., Tarabichi M., Dom G., Hebrant A., van Staveren W.C.G., Maenhaut C.
Thyroid cancer cell lines: an overview.
Front. Endocrinol. 3:133.1-133.9(2012)
PubMed=23833040; DOI=10.1210/jc.2013-2383
Landa I., Ganly I., Chan T.A., Mitsutake N., Matsuse M., Ibrahimpasic T., Ghossein R.A., Fagin J.A.
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)
PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)
PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
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PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)
PubMed=28775782; DOI=10.7150/jca.18855
Caria P., Pillai R., Dettori T., Frau D.V., Zavattari P., Riva G., Romano G., Pani F., Bentivegna A., Giovannoni R., Pagni F., Sogos V., Vanni R.
Thyrospheres from B-CPAP cell line with BRAF and TERT promoter mutations have different functional and molecular features than parental cells.
J. Cancer 8:1629-1639(2017)
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Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
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货号 | 产品名称 | 规格 | 价格 | 指令 |
ZQ0281 | TTA1人甲状腺癌细胞(STR鉴定) | 5 x 10^5 cells/vial | ¥1500.00 | 放入购物车 》 |
ZQ0305 | 8305C人甲状腺癌细胞(STR鉴定) | 5 x 10^5 cells/vial | ¥1350.00 | 放入购物车 》 |
ZQ0310 | ACT-1人甲状腺癌细胞(STR鉴定) | 5 x 10^5 cells/vial | ¥1500.00 | 放入购物车 》 |
ZQ0311 | CAL-62人甲状腺癌细胞(STR鉴定) | 5 x 10^5 cells/vial | ¥1350.00 | 放入购物车 》 |
ZQ0312 | BHT101人甲状腺癌细胞(STR鉴定) | 1 x 10^6 cells/vial | ¥1800.00 | 放入购物车 》 |
ZQ0314 | HTh-7人甲状腺癌细胞(STR鉴定)[套餐促销] | 5 x 10^5 cells/vial | ¥1200.00 | 放入购物车 》 |
ZQ0315 | Hth83人甲状腺癌细胞(STR鉴定) | 5 x 10^5 cells/vial | ¥1600.00 | 放入购物车 》 |
ZQ0316 | KHM-5M人甲状腺癌细胞(STR鉴定) | 5 x 10^5 cells/vial | ¥1350.00 | 放入购物车 》 |
ZQ0317 | KMH-2人甲状腺癌细胞(STR鉴定) | 5 x 10^5 cells/vial | ¥1500.00 | 放入购物车 》 |
ZQ0318 | KTC-1人甲状腺癌细胞(STR鉴定) | 5 x 10^5 cells/vial | ¥1350.00 | 放入购物车 》 |
ZQ0319 | Ocut-2C人甲状腺癌细胞(STR鉴定) | 5 x 10^5 cells/vial | ¥1600.00 | 放入购物车 》 |
ZQ0321 | C643人甲状腺癌细胞(STR鉴定)[套餐促销] | 5 x 10^5 cells/vial | ¥1350.00 | 放入购物车 》 |
A1001-1 | 国产转染试剂 | 1ml | ¥800.00 | 放入购物车 》 |
1 | 慢病毒介导基因沉默或过表达 | ¥询价 | 放入购物车 》 | |
ZQ500 | 国产优级胎牛血清 | 500ml | ¥1800.00 | 放入购物车 》 |
3 | 细菌基因敲除 | ¥询价 | 放入购物车 》 | |
ZQ-200 | RPMI-1640基础培养基 | 500ml | ¥56.00 | 放入购物车 》 |
ZQ-201 | RPMI-1640完全培养基 | 500ml | ¥350.00 | 放入购物车 》 |