产品名称	769-P人肾细胞腺癌细胞
货号	ZQ0341
产品介绍	769-P细胞系是一种人肾细胞癌(RCC)细胞系，来源于1975年一位患有肾细胞腺癌的63岁女性患者的肾切除术标本。这株细胞来源于原发性透明细胞腺癌。细胞呈边界不清楚的球形，高核质比，有微绒毛和桥粒。可以在软琼脂中生长。它被广泛应用于肾细胞癌的研究，特别是透明细胞肾细胞癌(ccRCC)，这是成人肾癌中最常见和最致命的形式。其保留了原发性肾细胞癌的许多特征，并含有与肾细胞癌相关的几种突变。它们在von Hippel-Lindau (VHL)肿瘤抑制基因中表现出功能缺失，该基因是ccRCC中重要的肾癌基因，可以激活多种致癌途径，包括血管生成、细胞增殖和代谢重编程。 该细胞系用于了解肾癌发病的分子机制，探索抗癌药物的疗效，探讨耐药机制。这些细胞对于研究对酪氨酸激酶抑制剂(TKIs)的反应特别有用，TKIs是用于治疗RCC和RCC亚型的一类靶向疗法。除此之外该细胞系也被进一步用于研究肿瘤微环境在肾癌中的作用，并研究细胞凋亡、细胞周期调节和转移潜能等细胞过程。它们对低氧条件的反应使它们适合于研究ccRCC如何适应实体肿瘤中的低氧环境并茁壮成长。 综上所述，769-P细胞系和其他RCC细胞系是肾癌研究中不可或缺的工具，可以深入了解ccRCC的发病机制、药物疗效和耐药机制。
种属	人
性别/年龄	女/63岁
组织	肾
疾病	肾细胞腺癌
细胞类型	肿瘤细胞
形态学	上皮的
生长方式	贴壁
倍增时间	大约35小时
培养基和添加剂	RPMI-1640（中乔新舟 货号：ZQ-200）+10%FBS（品牌：中乔新舟 货号：ZQ500-A）+1%P/S（中乔新舟  货号：CSP006）
推荐完全培养基货号	ZM0341
生物安全等级	BSL-1
STR位点信息	Amelogenin: X CSF1PO: 11,12 D13S317: 10,14 D16S539: 9,13 D5S818: 12 D7S820: 10,11 TH01: 6,9.3 TPOX: 8,11 vWA: 18
培养条件	95%空气，5%二氧化碳；37℃
抗原表达/受体表达	***
基因表达	***
保藏机构	ATCC; CRL-1933
供应限制	仅供科研使用

货号	ZQ0341
发货规格	活细胞：T25培养瓶*1瓶或者1ml 冻存管*1支（细胞量约为5 x 10^5 cells/vial）二选一
发货形式	活细胞：常温运输；冻存管：干冰运输
储存温度	活细胞：培养箱；冻存管：液氮罐
产地	中国
供应限制	仅供科研使用

论文标题： Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma
DOI： 10.20892/j.issn.2095-3941.2020.0186
发表时间： 2021-02-15
期刊： Cancer Biology & Medicine
影响因子： 4.248
货号： ZQ0341
产品名称： 769-P cell

原文链接： https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877181/

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