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人肝脂肪变性定量PCR芯片试剂盒
英文名:GeneQuery™ Human Hepatic Steatosis qPCR Array Kit
货号:GK045
价格:¥4320.00
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人肝脂肪变性定量PCR芯片试剂盒描述:



       ScienCell's GeneQuery™ Human Hepatic Steatosis qPCR Array Kit (GQH-HST) is designed to facilitate gene expression profiling of 88 key genes involved in hepatic steatosis pathogenesis. Hepatic steatosis, also known as fatty liver disease, refers to the accumulation of excessive triglycerides and other lipids in hepatocytes, mainly due to defective fatty acid metabolism. The most common causes of hepatic steatosis include hepatic insulin resistance, alcoholism, obesity or imbalance between energy intake and consumption, and genetic inheritance. Brief examples of how included genes may be grouped are shown below:


       Insulin signaling pathways: SOCS3, PPARGC1A, AKT1, MTOR, GSK3B, INSR, IRS1, FOXO1, PIK3R1, SOCS3, SREBF1

       Cholesterol metabolism: APOC3, APOA1, APOB, APOE, LDLR, PPARG, SREBF1, SREBF2, NR1H3, CYP2E1

       Carbohydrate metabolism: G6PC, G6PD, ACLY, PCK2, PDK4, RBP4, GSK3B

       Beta-oxidation: CPT1A, CPT2, FABP1, ACADL, ACOX1, AKT1, CD36, MTOR

       Adipokine signaling pathways: PPARGC1A, MTOR, LEPR, IRS1, ADIPOR1, ADIPOR2, NFKB1, SLC2A1, SLC2A4, TNF

       Hepatotoxicity steatosis: CD36, FASN, LPL, SCD, PPARA, SREBF1

       Genes implicated in


       Type II diabetes: IRS1, INSR, MAPK8, SLC2A2, SLC2A4, XBP1, TNF, PKLR, PNPLA3

       Non-alcoholic fatty liver disease: PNPLA3, SQSTM1, INS, GPT, ADIPOQ, TNF, SLC17A5, LEP, KRT18

       Reye's syndrome: ACADM, OTC, HMGCL, HADHA, OAT, ASS1, HMGCR, CES1

       Lipodystrophy: LMNA, LEP, IRS4, PDE3B, PTRF, GFPT1


       GeneQuery™ qPCR array kits are qPCR ready in a 96-well plate format, with each well containing one primer set that can specifically recognize and efficiently amplify a target gene's cDNA. The carefully designed primers ensure that: (i) the optimal annealing temperature in qPCR analysis is 65°C (with 2 mM Mg2+, and no DMSO); (ii) the primer set recognizes all known transcript variants of target gene, unless otherwise indicated; and (iii) only one gene is amplified. Each primer set has been validated by qPCR with melt curve analysis, and gel electrophoresis.


       GeneQuery™ Human Hepatic Steatosis qPCR Array Plate Layout*(8 controls in Bold and Italic)



 

1

2

3

4

5

6

7

8

9

10

11

12

A

AKT1

CLEC4M

EIF3E

IFNA2

IRF3

MAPK14

OAS1

PIK3R1

PPP2R1B

RIPK1

STAT6

β-actin

B

AKT2

DDX58

GGT1

IFNAR1

JAK1

MAPK3

OAS2

PIK3R2

PPP2R2A

RNASEL

TBK1

GAPDH

C

AKT3

EGFR

GPT

IFNAR2

LDLR

MAPK8

OAS3

PIK3R3

PPP2R2B

RXRA

TICAM1

LDHA

D

BAD

EIF2AK1

GRB2

IFNB1

MAPK1

MAPK9

OCLN

PIK3R5

PPP2R2C

SCARB1

TLR3

NONO

E

CD81

EIF2AK2

HM13

IKBKB

MAPK10

MAVS

PDPK1

PPARA

PPP2R2D

SOS1

TNFRSF1A

PPIH

F

CDKN1A

EIF2AK3

IFIT1

IKBKE

MAPK11

NFKB1

PIAS1

PPP2CA

PSME3

SOS2

TRADD

GDC

G

CHUK

EIF2AK4

IFIT1B

IKBKG

MAPK12

NFKBIA

PIK3CB

PPP2CB

RAF1

STAT1

TRAF2

PPC

H

CLDN1

EIF2S1

IFNA1

IRF1

MAPK13

NR1H3

PIK3CG

PPP2R1A

RELA

STAT2

TYK2

NTC

 

* gene selection may be updated based on new research and development


产品使用说明:仅供科研研究使用

货号

GK045

产地

美国

缩写

GQH-HST

规格

One 96-well plate, one 20ul reaction per well

用途

科研

保存

4°C or -20°C

运输

常温

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